KnowledgeBase Articles Archive

Molecular recognition of 3 + 1 hybrid human telomeric G-quadruplex DNA d-[AGGG(TTAGGG)3] by anticancer drugs epirubicin and adriamycin leads to thermal stabilization

2019 / International Journal of Biological Macromolecules

Recent reports suggest influence of anti-cancer anthracyclines on telomere dysfunction and their possible interaction with G-quadruplex (G4) DNA as an… Continue reading Molecular recognition of 3 + 1 hybrid human telomeric G-quadruplex DNA d-[AGGG(TTAGGG)3] by anticancer drugs epirubicin and adriamycin leads to thermal stabilization

Characterization of a MnII complex of Alizarin suggests attributes explaining a superior anticancer activity: A comparison with anthracycline drugs

2019 / Polyhedron

Alizarin (DHA), a simple analogue of the anthracycline core was used to form a complex with MnII to see if the… Continue reading Characterization of a MnII complex of Alizarin suggests attributes explaining a superior anticancer activity: A comparison with anthracycline drugs

Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells

2019 / Journal of Medicinal Chemistry

In order to optimize the potency of the first serum-stable peptide agonist of CD47 (PKHB1) in triggering regulated cell death… Continue reading Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells

Electron Transport in Muscle Protein Collagen

2019 / Langmuir

In recent times, collagen, which is one of the most abundant proteins in animals, has appeared to be an attractive… Continue reading Electron Transport in Muscle Protein Collagen

Local DNA Base Conformations and Ligand Intercalation in DNA Constructs Containing Optical Probes

2019 / Biophysical Journal

Understanding local conformations of DNA at the level of individual nucleic acid bases and base pairs is important for elucidating… Continue reading Local DNA Base Conformations and Ligand Intercalation in DNA Constructs Containing Optical Probes

The structural dynamics of the kinesin-2 stalk heterodimer and its biological relevance

2019 / Biochemical and Biophysical Research Communications

Association between two motor subunits through the rod/stalk domain enables molecular motors to walk processively on protein filaments. Previous studies… Continue reading The structural dynamics of the kinesin-2 stalk heterodimer and its biological relevance

Collagen from Turkey (Meleagris gallopavo) tendon: A promising sustainable biomaterial for pharmaceutical use

2019 / Sustainable Chemistry and Pharmacy

Collagen is the major fibrillar component and protein in both human and animal connective tissue. It is applied in medical… Continue reading Collagen from Turkey (Meleagris gallopavo) tendon: A promising sustainable biomaterial for pharmaceutical use

Folic acid decorated magnetic nanosponge: An efficient nanosystem for targeted curcumin delivery and magnetic resonance imaging

2019 / Journal of Colloid and Interface Science

Magnetic drug delivery system is one of the most important strategies for cancer diagnosis and treatment. In this study, a… Continue reading Folic acid decorated magnetic nanosponge: An efficient nanosystem for targeted curcumin delivery and magnetic resonance imaging

Molecular level insight into the counteraction of trehalose on the activity as well as denaturation of lysozyme induced by guanidinium chloride

2020 / Chemical Physics

The effect of trehalose on the activity and structural change of lysozyme induced by the chemical denaturant guanidinium chloride (GdmCl)… Continue reading Molecular level insight into the counteraction of trehalose on the activity as well as denaturation of lysozyme induced by guanidinium chloride

Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells

2019 / Bioorganic Chemistry

Vernonia extensa, known as “Phim Phai Lin” in Thai, is distributed in most regions of Thailand. The plant has been… Continue reading Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells

Cleavage and transformation inhibition of extracellular antibiotic resistance genes by graphene oxides with different lateral sizes

2019 / Science of The Total Environment

Due to excessive consumption of antibiotics, antibiotic resistance genes (ARGs) become a ubiquitous pollutant in aquatic environments. Graphene oxide (GO),… Continue reading Cleavage and transformation inhibition of extracellular antibiotic resistance genes by graphene oxides with different lateral sizes

Targeted and MMP-2/9 responsive peptides for the treatment of rheumatoid arthritis

2019 / International Journal of Pharmaceutics

Bioactive peptides are attractive candidates for drug development. QAW is a tripeptide that is obtained from an anti-inflammatory protein-Annexin A1… Continue reading Targeted and MMP-2/9 responsive peptides for the treatment of rheumatoid arthritis

Caryophyllene sesquiterpenes, chromones and 10-membered macrolides from the marine-derived fungus Pseudopestalotiopsis sp. PSU-AMF45

2019 / Tetrahedron

Three new caryophyllene sesquiterpenes, pestalotiopsins I–K, one new chromone, pseudopestalone, and one new 10-membered macrolide, decarestrictine Q, were isolated from… Continue reading Caryophyllene sesquiterpenes, chromones and 10-membered macrolides from the marine-derived fungus Pseudopestalotiopsis sp. PSU-AMF45

Efficient DNA-Catalyzed Porphyrin Metalation for Fluorescent Ratiometric Pb2+ Detection

2019 / Analytical Chemistry

Developing biosensors for Pb2+ is an important analytical topic. DNA-based Pb2+ sensors have been designed mainly based on RNA-cleaving DNAzymes and Pb2+-induced… Continue reading Efficient DNA-Catalyzed Porphyrin Metalation for Fluorescent Ratiometric Pb2+ Detection

Energy Transfer Induced by Dye Encapsulation in a Hybrid Nanoparticle‐Purple Membrane Reversible Assembly

2019 / Advanced Functional Materials

The purple membrane (PM) isolated from the bacteria Halobacterium salinarum (H. salinarum) arranges the transmembrane proton pump bacteriorhodopsin (bR) in a 2D… Continue reading Energy Transfer Induced by Dye Encapsulation in a Hybrid Nanoparticle‐Purple Membrane Reversible Assembly

Alternative Assembly of α-Synuclein Leading to Protein Film Formation and Its Application for Developing Polydiacetylene-Based Sensing Materials

2019 / Langmuir

Understanding the self-assembly process of amyloidogenic protein is valuable not only to find its pathological implication but also to prepare… Continue reading Alternative Assembly of α-Synuclein Leading to Protein Film Formation and Its Application for Developing Polydiacetylene-Based Sensing Materials

Targeting multiple G-quadruplex–forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives

2019 / European Journal of Medicinal Chemistry

It is well recognized that the non-canonical DNA structures known as G-quadruplexes (G4s) have a potential anticancer significance and several… Continue reading Targeting multiple G-quadruplex–forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives

Electronic circular dichroism imaging (CDi) maps local aggregation modes in thin films of chiral oligothiophenes

2019 / New Journal of Chemistry

We highlight the power of electronic circular dichroism imaging (CDi), a technique developed at Diamond Light Source B23 beamline for… Continue reading Electronic circular dichroism imaging (CDi) maps local aggregation modes in thin films of chiral oligothiophenes

Cysteine Residue Containing Merocytochalasans and 17,18-seco-Aspochalasins from Aspergillus micronesiensis

2019 / Journal of Natural Products

Two cysteine residue containing merocytochalasans (cyschalasins A and B, 1 and 2) and two 17,18-seco-aspochalasins (secochalasins A and B, 3 and 4) were isolated from the… Continue reading Cysteine Residue Containing Merocytochalasans and 17,18-seco-Aspochalasins from Aspergillus micronesiensis

Preparation and characterization of a highly soluble Aβ1-42 peptide variant

2019 / Protein Expression and Purification

Alzheimer’s disease (AD) is a progressive neurological disease marked by the accumulation and deposition of misfolded amyloid beta or Abeta… Continue reading Preparation and characterization of a highly soluble Aβ1-42 peptide variant

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