Poly(2-isopropyl-2-oxazoline)-b-poly(lactide) (PiPOx-b-PLA) diblock copolymers comprise two miscible blocks: the hydrophilic and thermosensitive PiPOx and the hydrophobic PLA, a biocompatible and… Continue reading Poly(2-isopropyl-2-oxazoline)-b-poly(lactide) (PiPOx-b-PLA) Nanoparticles in Water: Interblock van der Waals Attraction Opposes Amphiphilic Phase Separation
Leah Pandiscia, PhD
April 9, 2019
Histone deacetylases, HDACs, have been demonstrated to play a critical role in epigenetic signaling and were found to be overexpressed… Continue reading Unprecedented Behavior of (9R)-9-Hydroxystearic Acid-Loaded Keratin Nanoparticles on Cancer Cell Cycle
Leah Pandiscia, PhD
April 9, 2019
Cellulose nanocrystals (CNCs) derived from biomass spontaneously organize into a helical arrangement, termed a chiral nematic structure. This structure mimics… Continue reading Unwinding a spiral of cellulose nanocrystals for stimuli-responsive stretchable optics
Leah Pandiscia, PhD
April 9, 2019
The formation of intercalated motifs (iMs) — secondary DNA structures based on hemiprotonated C.C+ pairs in suitable cytosine-rich DNA sequences, is… Continue reading Systematic investigation of sequence requirements for DNA i-motif formation
Leah Pandiscia, PhD
April 9, 2019
Scorpion venom constitutes a rich source of biologically active compounds with high potential for therapeutic and biotechnological applications that can… Continue reading Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Peroxiredoxins(Prdx), the family of non-selenium glutathione peroxidases, are important antioxidant enzymes that defend our system from the toxic reactive oxygen… Continue reading Hyperoxidation of Peroxiredoxin 6 Induces Alteration from Dimeric to Oligomeric State
Leah Pandiscia, PhD
April 9, 2019
The purification of phosphorylated proteins in a folded state and in large enough quantity for biochemical or biophysical analysis remains… Continue reading Scalable, Non-denaturing Purification of Phosphoproteins Using Ga3+-IMAC: N2A and M1M2 Titin Components as Study case
Leah Pandiscia, PhD
April 9, 2019
We report an extensive study on the coordination behavior of chiral ditopic bridging ligands, which lead to metallosupramolecular polymers in… Continue reading Chiral Self-Sorting Process with Ditopic Ligands: Alternate or Block Metallopolymer Assembly as a Function of the Metal Ion
Leah Pandiscia, PhD
April 9, 2019
Foldamers, which are folded oligomers with well-defined conformations, have been recently reported to have a good cell-penetrating ability. α,α-Disubstituted α-amino… Continue reading Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers
Leah Pandiscia, PhD
April 9, 2019
Metal–organic polyhedra (MOP) are ultrasmall (typically 1–4 nm) porous coordination cages made from the self-assembly of metal ions and organic… Continue reading Postsynthetic Covalent and Coordination Functionalization of Rhodium(II)-Based Metal–Organic Polyhedra
Leah Pandiscia, PhD
April 9, 2019
Three new compounds, namely, 4-(4′-hydroxy-3′-methoxyphenyl)-3,5,7-trihydroxycoumarin (1) and sulawesins A (2) and B (3), were isolated from the propolis of stingless… Continue reading Propolis Components from Stingless Bees Collected on South Sulawesi, Indonesia, and Their Xanthine Oxidase Inhibitory Activity
Leah Pandiscia, PhD
April 9, 2019
Amyloids are polypeptide supramolecular assemblies that have been historically associated with numerous pathologies. Nonetheless, recent studies have identified many amyloid… Continue reading Glycosaminoglycans Induce Amyloid Self-Assembly of a Peptide Hormone by Concerted Secondary and Quaternary Conformational Transitions
Leah Pandiscia, PhD
April 9, 2019
Human neuroglobin (Ngb) forms an intramolecular disulfide bond between Cys46 and Cys55, with a third Cys120 near the protein surface,… Continue reading Enhancement of protein stability by an additional disulfide bond designed in human neuroglobin
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
The aggregation of α-synuclein (α-syn) into amyloid fibrils is a major pathological hallmark of Parkinson’s disease (PD) and other synucleinopathies. The mechanisms underlying the… Continue reading Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Surface nanotopograpy has been recognized as an important regulator of cellular responses including those of immune cells, the latter being… Continue reading Nanotopography‐Induced Unfolding of Fibrinogen Modulates Leukocyte Binding and Activation
Leah Pandiscia, PhD
April 9, 2019
The interaction of neuropeptides, vasoactive intestinal peptide (VIP), or growth hormone-releasing hormone (GHRH), with a cationic carbosilane dendrimer forms dendriplexes… Continue reading Anticancer Activity of Dendriplexes against Advanced Prostate Cancer from Protumoral Peptides and Cationic Carbosilane Dendrimers
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019