A set of four organogelators from an α-amino acid derivative to a tetrapeptide, covalently linked to an acetylenic moiety, was… Continue reading From self-assembled peptide-ynes to peptide polyacetylenes and polydiacetylenes
Leah Pandiscia, PhD
October 11, 2018
The pollution of heavy metals is a severer problem for the ecosystems in waters. The toxicity of Cd2+ on phycocyanin (PC)… Continue reading The toxicity of cadmium ion (Cd2+) to phycocyanin: an in vitro spectroscopic study
Leah Pandiscia, PhD
October 11, 2018
Fluorinated peptides attract much interest in the biomedical area because they generally exhibit an enhanced stability compared to their hydrogenated… Continue reading Lipid membrane interactions of a fluorinated peptide with potential ion channel-forming ability
Leah Pandiscia, PhD
October 11, 2018
Polyhydroxyalkanoate (PHA) is a class of microbial synthesized biodegradable and biocompatible aliphatic polymer which has been developed into nanoparticles (NPs)… Continue reading Development and optimization of a tumor targeting system based on microbial synthesized PHA biopolymers and PhaP mediated functional modification
Leah Pandiscia, PhD
October 11, 2018
Previous work demonstrated that lysine homopeptides adopt a polyproline II (PPII) structure. Lysine homopeptides with odd number of residues, especially… Continue reading Understanding the antimicrobial properties/activity of an 11-residue Lys homopeptide by alanine and proline scan
Leah Pandiscia, PhD
October 11, 2018
Bacteriocins hold unprecedented promise as a largely untapped source of antibiotic alternatives in the age of multidrug resistance. Here, we… Continue reading Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48
Leah Pandiscia, PhD
October 11, 2018
Self‐assembling molecular systems often display amplified chirality compared to the monomeric state, which makes the molecular recognition more sensitive to… Continue reading Enantioselective Light Harvesting with Perylenediimide Guests on Self-Assembled Chiral Naphthalenediimide Nanofibers
Leah Pandiscia, PhD
October 11, 2018
GAS41 is a chromatin-associated protein that belongs to the YEATS family and is involved in the recognition of acetyl-lysine in… Continue reading GAS41 recognizes di-acetylated histone H3 through a bivalent binding mode
Leah Pandiscia, PhD
October 11, 2018
Serine protease HtrA2 (High temperature requirement protease A2), is involved in apoptosis and protein quality control. However, one of its… Continue reading Structural Basis of Inactivation of Human Counterpart of Mouse Motor Neuron Degeneration 2 Mutant in Serine Protease HtrA2
Leah Pandiscia, PhD
October 11, 2018
Membrane lipids play critical roles in the structure and function of membrane-embedded transporters. Salmonella typhimurium MelB (MelBSt) is a symporter… Continue reading Structural and functional characterization of protein–lipid interactions of the Salmonella typhimurium melibiose transporter MelB
Leah Pandiscia, PhD
October 11, 2018
Thermostable cellulases offer several advantages like higher rates of substrate hydrolysis, lowered risk of contamination, and increased flexibility with respect… Continue reading Functional Expression of a Thermostable Endoglucanase from Thermoascus aurantiacus RCKK in Pichia pastorisX-33 and Its Characterization
Leah Pandiscia, PhD
October 11, 2018
Four copper(II) coordination compounds from 2-benzimidazole propionic acid (Hbzpr) and 4-(benzimidazol-2-yl)-3-thiobutanoic acid (Hbztb) were synthesized and fully characterized by elemental… Continue reading Efficient copper-based DNA cleavers from carboxylate benzimidazole ligands
Leah Pandiscia, PhD
October 11, 2018
Human pancreatic cancer cells have an extreme tolerance to nutrition starvation, enabling them to survive in a hypovascular tumor microenvironment.… Continue reading Chemical Constituents of Thai Citrus hystrix and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Fep1, the iron-dependent GATA-type transcriptional repressor of the methylotrophic yeast Pichia pastoris, has a dimeric structure and binds an iron–sulfur cluster… Continue reading Mutational Analysis of the Cysteine-Rich Region of the Iron-Responsive GATA Factor Fep1. Role of Individual Cysteines as [2Fe–2S] Cluster Ligands
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Milk components, such as proteins and lipids, have different physicochemical properties depending upon the mammalian species from which they come.… Continue reading The self-association and thermal denaturation of caprine and bovine β-lactoglobulin
Leah Pandiscia, PhD
October 11, 2018
A new lectin from the marine red alga Meristiella echinocarpa (MEL) was isolated and biochemically characterized. MEL is a monomeric protein of… Continue reading Meristiella echinocarpa lectin (MEL): a new member of the OAAH-lectin family
Leah Pandiscia, PhD
October 11, 2018
The encapsulation of Pt and Au-based anticancer agents within a protein cage is a promising way to enhance the selectivity… Continue reading Caged noble metals: Encapsulation of a cytotoxic platinum(II)-gold(I) compound within the ferritin nanocage
Leah Pandiscia, PhD
October 11, 2018
New steroidal imidazolidinthione derivatives (4-6) were synthesized from steroidal thiosemicarbazones and dichloroethane. The synthesized compounds were characterized using spectral data… Continue reading Synthesis of steroidal imidazolidinthiones as potential apoptotic agents: Investigation by theoretical and experimental studies
Leah Pandiscia, PhD
October 11, 2018