Found 9617 Results / Page 326 of 481
2011 / PLoS ONE
Apolipoprotein E (apoE) is a major protein of the lipoprotein transport system that plays important roles in lipid homeostasis and… Continue reading Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia
2012 / PLoS ONE
The bloodstream developmental forms of pathogenic African trypanosomes are uniquely susceptible to killing by small hydrophobic peptides. Trypanocidal activity is… Continue reading Novel African Trypanocidal Agents: Membrane Rigidifying Peptides
2009 / PLoS ONE
The yellow fever mosquito, Aedes aegypti, is the primary vector for the viruses that cause yellow fever, mostly in tropical regions… Continue reading Structure of an Odorant-Binding Protein from the Mosquito Aedes aegypti Suggests a Binding Pocket Covered by a pH-Sensitive “Lid”
2015 / PLoS Pathogens
A transcriptome analysis identified Vibrio vulnificus cabABC genes which were preferentially expressed in biofilms. The cabABC genes were transcribed as a single operon. The cabA gene… Continue reading The cabABC Operon Essential for Biofilm and Rugose Colony Development in Vibrio vulnificus
2012 / PLoS ONE
A unique peptide toxin, named double-knot toxin (DkTx), was recently purified from the venom of the tarantula Ornithoctonus huwena and was found… Continue reading High Yield Production and Refolding of the Double-Knot Toxin, an Activator of TRPV1 Channels
2014 / PLoS ONE
Endoribonuclease E (RNase E) affects the composition and balance of the RNA population in Escherichia coli via degradation and processing of RNAs.… Continue reading Modulation of RNase E Activity by Alternative RNA Binding Sites
2013 / PLoS ONE
Prion diseases are transmissible spongiform encephalopathies in humans and animals, including scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle,… Continue reading Seeded Fibrillation as Molecular Basis of the Species Barrier in Human Prion Diseases
2013 / PLoS ONE
The computational protein design protocol Rosetta has been applied successfully to a wide variety of protein engineering problems. Here the… Continue reading Octarellin VI: Using Rosetta to Design a Putative Artificial (β/α)8 Protein
2013 / PLoS ONE
Conotoxins (CTxs) selectively target a range of ion channels and receptors, making them widely used tools for probing nervous system… Continue reading A Novel Inhibitor of α9α10 Nicotinic Acetylcholine Receptors from Conus vexillum Delineates a New Conotoxin Superfamily
2012 / PLoS ONE
Iron is an essential micronutrient for all organisms because it is a component of enzyme cofactors that catalyze redox reactions… Continue reading Alteration of Proteins and Pigments Influence the Function of Photosystem I under Iron Deficiency from Chlamydomonas reinhardtii
2011 / PLoS ONE
In some bacterial species and photosynthetic cohorts, including algae, the enzyme l,l-diaminopimelate aminotransferase (DapL) (E.C. 2.6.1.83) is involved in the anabolism… Continue reading L,L-Diaminopimelate Aminotransferase from Chlamydomonas reinhardtii: A Target for Algaecide Development
2012 / PLoS ONE
Leucine-rich repeat kinase 1 and 2 (LRRK1 and LRRK2) are large multidomain proteins containing kinase, GTPase and multiple protein-protein interaction… Continue reading Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers
2011 / PLoS ONE
Ferritins are recognized as key players in the iron storage and detoxification processes. Iron acquisition in the case of pathogenic… Continue reading Ferritin Structure from Mycobacterium tuberculosis: Comparative Study with Homologues Identifies Extended C-Terminus Involved in Ferroxidase Activity
2012 / PLoS ONE
During the process of HIV-1 fusion with the target cell, the N-terminal heptad repeat (NHR) of gp41 interacts with the… Continue reading The Conserved Residue Arg46 in the N-Terminal Heptad Repeat Domain of HIV-1 gp41 Is Critical for Viral Fusion and Entry
2012 / PLoS ONE
[FeFe]-hydrogenases reversibly catalyse molecular hydrogen evolution by reduction of two protons. Proton supply to the catalytic site (H-cluster) is essential… Continue reading Site Saturation Mutagenesis Demonstrates a Central Role for Cysteine 298 as Proton Donor to the Catalytic Site in CaHydA [FeFe]-Hydrogenase
2011 / PLoS ONE
Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as… Continue reading Machupo Virus Glycoprotein Determinants for Human Transferrin Receptor 1 Binding and Cell Entry
2011 / PLoS ONE
4-hydroxy-2-oxoglutarate (HOG) aldolase is a unique enzyme in the hydroxyproline degradation pathway catalyzing the cleavage of HOG to pyruvate and… Continue reading Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria
2012 / PLoS ONE
Zbed4, a member of the BED subclass of Zinc-finger proteins, is expressed in cone photoreceptors and glial Müller cells of… Continue reading Sequence-Specific Binding of Recombinant Zbed4 to DNA: Insights into Zbed4 Participation in Gene Transcription and Its Association with Other Proteins
2011 / PLoS ONE
Strepsirrhines are members of a primate suborder that has a distinctive set of features associated with the development of the… Continue reading Structural Analysis of a Repetitive Protein Sequence Motif in Strepsirrhine Primate Amelogenin
2011 / PLoS ONE
Autoinducer-2 (AI-2) mediated quorum sensing has been associated with the expression of virulence factors in a number of pathogenic organisms… Continue reading Identification of a Key Amino Acid of LuxS Involved in AI-2 Production in Campylobacter jejuni
