KnowledgeBase Articles Archive

A case of neofunctionalization of a Putranjiva roxburghii PNP protein to trypsin inhibitor by disruption of PNP-UDP domain through an insert containing inhibitory site

2017 / Plant Science

The attainment of new function by a protein is achieved through convergent/divergent evolution. In present work, the sequence analysis of… Continue reading A case of neofunctionalization of a Putranjiva roxburghii PNP protein to trypsin inhibitor by disruption of PNP-UDP domain through an insert containing inhibitory site

pH-responsive pHLIP (pH low insertion peptide) nanoclusters of superparamagnetic iron oxide nanoparticles as a tumor-selective MRI contrast agent

2017 / Acta Biomaterialia

Superparamagnetic iron oxide nanoparticles (SPION) are contrast agents used for noninvasive tumor magnetic resonance imaging (MRI). SPION with active targeting… Continue reading pH-responsive pHLIP (pH low insertion peptide) nanoclusters of superparamagnetic iron oxide nanoparticles as a tumor-selective MRI contrast agent

Assessing safety and protein interactions of surface-modified iron oxide nanoparticles for potential use in biomedical areas

2017 / Colloids and Surfaces B: Biointerfaces

We have investigated the electrostatic interaction between bare iron oxide nanoparticles (IONPs) or low molecular weight chitosan coated iron oxide… Continue reading Assessing safety and protein interactions of surface-modified iron oxide nanoparticles for potential use in biomedical areas

Synthesis and in vitro evaluation of fluorescent and magnetic nanoparticles functionalized with a cell penetrating peptide for cancer theranosis

2017 / Journal of Colloid and Interface Science

We synthesized rationally designed multifunctional nanoparticles (NPs) composed of a superparamagnetic iron oxide nanoparticle (SPION) core, cyanine fluorescent dye emitting… Continue reading Synthesis and in vitro evaluation of fluorescent and magnetic nanoparticles functionalized with a cell penetrating peptide for cancer theranosis

Small Molecule Induced Poly(A) Single Strand to Self-Structure Conformational Switching: Evidence for the Prominent Role of H-bonding Interactions

2017 / Molecular BioSystems

All messenger RNAs (mRNA) have a polyadenylic acid tail that is added during the post transcriptional RNA processing. Investigations on… Continue reading Small Molecule Induced Poly(A) Single Strand to Self-Structure Conformational Switching: Evidence for the Prominent Role of H-bonding Interactions

Optimized Triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

2017 / PLoS ONE

Investigations into the immunological response of proteins is often masked by lipopolysaccharide (LPS) contamination. We report an optimized Triton X-114… Continue reading Optimized Triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Binuclear ruthenium complexes inhibit the fibril formation of human islet amyloid polypeptide

2017 / RSC Advances

The deposition of human islet amyloid polypeptide (hIAPP) is closely correlated with type II diabetes mellitus (T2DM). hIAPP misfolding, as… Continue reading Binuclear ruthenium complexes inhibit the fibril formation of human islet amyloid polypeptide

A Lipopeptide HIV-1/2 Fusion Inhibitor with Highly Potent in vitro, ex vivo and in vivo Antiviral Activity

2017 / Journal of Virology

Peptides derived from the C-terminal heptad repeat (CHR) region of the HIV-1 fusogenic protein gp41 are potent viral entry inhibitors,… Continue reading A Lipopeptide HIV-1/2 Fusion Inhibitor with Highly Potent in vitro, ex vivo and in vivo Antiviral Activity

Two pairs of Zn(II) coordination polymer enantiomers based on chiral aromatic polycarboxylate ligands: synthesis, crystal structures and properties

2017 / RSC Advances

Two pairs of Zn-based chiral coordination polymers (CCPs), namely, [Zn((R)-cbca)·H2O], [Zn((S)-cbca)]·H2O], [Zn((R)-cna)·2H2O] and [Zn((S)-cna)·2H2O] {H2cbca = (R) or (S)-4′-(1-carboxyethoxy)-[1,1′-biphenyl]-4-carboxylic acid,… Continue reading Two pairs of Zn(II) coordination polymer enantiomers based on chiral aromatic polycarboxylate ligands: synthesis, crystal structures and properties

Ultrasonic irradiation enhanced the ability of Fluorescein-DA-Fe(III) on sonodynamic and sonocatalytic damages of DNA molecules

2017 / Ultrasonics Sonochemistry

The interaction of DNA with Bis [N,N-bis (carboxymethyl) aminomethyl] fluorescein-Ferrous(III) (Fluorescein-DA-Fe(III)) with dual functional (sonodynamic and sonocatalytic) activity was studied… Continue reading Ultrasonic irradiation enhanced the ability of Fluorescein-DA-Fe(III) on sonodynamic and sonocatalytic damages of DNA molecules

Sensitive detection of alkaline phosphatase by switching on gold nanoclusters fluorescence quenched by pyridoxal phosphate

2017 / Biosensors and Bioelectronics

In this work, we designed highly sensitive and selective luminescent detection method for alkaline phosphatase using bovine serum albumin functionalized… Continue reading Sensitive detection of alkaline phosphatase by switching on gold nanoclusters fluorescence quenched by pyridoxal phosphate

Interaction of insulin with colloidal ZnS quantum dots functionalized by various surface capping agents

2017 / Materials Science and Engineering: C

Interaction of quantum dots (QDs) and proteins strongly influenced by the surface characteristics of the QDs at the protein-QD interface.… Continue reading Interaction of insulin with colloidal ZnS quantum dots functionalized by various surface capping agents

Human-derived fusogenic peptides for the intracellular delivery of proteins

2017 / Journal of Controlled Release

The cytosolic delivery of therapeutic proteins (e.g., antibodies or enzymes) by cell-penetrating peptides (CPPs), such as a human immunodeficiency virus-derived… Continue reading Human-derived fusogenic peptides for the intracellular delivery of proteins

Biophysical and molecular docking approaches for the investigation of biomolecular interactions between amphotericin B and bovine serum albumin

2017 / Journal of Photochemistry and Photobiology B: Biology

Exogenous drug as an antidote to treat various infections get absorbed in the blood circulatory system of a human can… Continue reading Biophysical and molecular docking approaches for the investigation of biomolecular interactions between amphotericin B and bovine serum albumin

Understanding the contribution of disulphide bridges to the folding and misfolding of an anti-Aβ scFv

2017 / Protein Science

ScFv-h3D6 is a single chain variable fragment that precludes Aβ peptide-induced cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway… Continue reading Understanding the contribution of disulphide bridges to the folding and misfolding of an anti-Aβ scFv

High-resolution 3D NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation

2017 / The Journal of Biological Chemistry

Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a… Continue reading High-resolution 3D NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation

Rassf Proteins as Modulators of Mst1 Kinase Activity

2017 / Scientific Reports

Rassf1A/5 tumor suppressors serve as adaptor proteins possessing a modular architecture with the C-terminal consisting of a coiled-coil SARAH (Salvador-Rassf-Hippo)… Continue reading Rassf Proteins as Modulators of Mst1 Kinase Activity

FRET guided surging of cyanobacterial photosystems improves and stabilizes current in photosynthetic microbial fuel cell

2017 / Journal of Materials Chemistry A

Improving power generation under low light condition and capturing electrons efficiently from the photosynthetic bacteria on the electrode are critical… Continue reading FRET guided surging of cyanobacterial photosystems improves and stabilizes current in photosynthetic microbial fuel cell

Biomimetic collagen/phospholipid coatings improve formation of hydroxyapatite nanoparticles on titanium

2017 / Materials Science and Engineering: C

Osseointegration between the surface of a certain material and the host tissue helps to evaluate the potential use of biomaterials… Continue reading Biomimetic collagen/phospholipid coatings improve formation of hydroxyapatite nanoparticles on titanium

From a metagenomic source to a high-resolution structure of a novel alkaline esterase

2017 / Applied Microbiology and Biotechnology

Esterases catalyze the cleavage and formation of ester bonds and are members of the diverse family of α/β hydrolase fold.… Continue reading From a metagenomic source to a high-resolution structure of a novel alkaline esterase

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