Found 9617 Results / Page 388 of 481
2016 / Applied Materials and Interfaces
An efficient method to deliver active proteins into cytosol is highly desirable to advance protein-based therapeutics. Arginine-rich cell-penetrating peptides (RPPs)… Continue reading An Efficient Mini-Transporter for Cytosolic Protein Delivery
2016 / Nature
Naturally occurring, pharmacologically active peptides constrained with covalent crosslinks generally have shapes that have evolved to fit precisely into binding… Continue reading Accurate de novo design of hyperstable constrained peptides
2016 / Journal of Organometallic Chemistry
In order to model the metal ion binding capabilities of high molecular mass components of blood the interaction between [(η6-p-cym)Ru(H2O)3]2+ and… Continue reading Complex formation between [(η6-p-cym)Ru(H2O)3]2+ and oligopeptides containing three histidyl moieties
2016 / The Journal of Physical Chemistry B
We demonstrated that the circular dichroism (CD) exciton chirality method based on the supramolecular interactions of meso-tetra(4-sulfonatophenyl)porphyrin (MTPPS4, M =… Continue reading Absolute Configuration Determination of Side Chains of Basic Amino Acid Residues Using Water-Soluble Porphyrins-Based Exciton Chirality Method
2016 / Polymer Chemistry
Biomolecule promoted helical polypeptides and their structural diversity towards external/internal stimuli is an interesting research area to the material science… Continue reading POSS semitelechelic Aβ17–19 peptide initiated helical polypeptides and their structural diversity in aqueous medium
2016 / Fitoterapia
From the twigs and stems of the Chinese liana Ancistrocladus tectorius(Ancistrocladaceae), two new 5,8′-coupled naphthylisoquinolines, ancistectorine D (5) and its 6-O-demethyl… Continue reading Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8′- and 7,1′-linked metabolites from the Chinese liana Ancistrocladus tectorius
2016 / Journal of Chromatography B
Isotopically labeled proteins have been used as internal standards for mass spectrometry (MS)-based absolute protein quantification. Although this approach can… Continue reading Preparation of soluble isotopically labeled human growth hormone produced in Escherichia coli
2016 / Journal of Photochemistry and Photobiology B: Biology
In this study, the 4-(1H-phenanthro[9,10-d]-imidazol-2-yl)-benzaldehyde (PB1) was investigated as a fluorescent dye. For this reason, the spectroscopic properties in different… Continue reading Synthesis, spectroscopic, physicochemical properties and binding site analysis of 4-(1H-phenanthro[9,10-d]-imidazol-2-yl)-benzaldehyde fluorescent probe for imaging in cell biology: Experimental and theoretical study
2016 / Toxicon
Spinoxin (SPX; α-KTx6.13), isolated from venom of the scorpion Heterometrus spinifer, is a K+ channel-specific peptide toxin (KTx), which adopts a cysteine-stabilized… Continue reading Role of individual disulfide bridges in the conformation and activity of spinoxin (α-KTx6.13), a potassium channel toxin from Heterometrus spinifer scorpion venom
2016 / International Journal of Biological Macromolecules
The binding behavior of nanoparticle with proteins determines its biocompatibility. This study reports the interaction of ten different biomolecules (proteins-BSA,… Continue reading Role of PAMAM-OH dendrimers against the fibrillation pathway of biomolecules
2016 / International Journal of Biological Macromolecules
Renilla luciferase is a sensitive enzyme and has wide applications in biotechnology such as drug screening. Previous studies tried to show… Continue reading Probing the emitter site of Renilla luciferase using small organic molecules; an attempt to understand the molecular architecture of the emitter site
2016 / Journal of Organometallic Chemistry
New chiral L-/d-valine-quercetin diorganotin(IV) complexes [(CH3)2Sn(Q)(val)] 1L/D, [(C6H5)2Sn(Q)(val)] 2L/D, were synthesized and thoroughly characterized by elemental analysis, mass spectrometry, IR, 1H NMR, 119Sn NMR… Continue reading Human Topoisomerase I mediated cytotoxicity profile of L-valine-quercetin diorganotin(IV) antitumor drug entities
2016 / Journal of Molecular Biology
The molecular chaperone Hsp90 and its cofactor Cdc37 are required for the stability of protein kinases in the cellular environment.… Continue reading Nucleotide-Free sB-Raf is Preferentially Bound by Hsp90 and Cdc37 In Vitro
2016 / Biochemistry
Insertion of a nascent membrane protein segment by the translocon channel into the bilayer is naturally promoted by high segmental… Continue reading Hydrophobic clusters raise the threshold hydrophilicity for insertion of transmembrane sequences in vivo
2016 / Chemistry A European Journal
A series of binuclear ruthenium(II)–polypyridyl complexes of the type [Ru2(N-N)4(BPIMBp)]4+, in which N-N is 2,2′-bipyridine (bpy; 1), 1,10-phenanthroline (phen; 2),… Continue reading Honeycomb-like Ordered Assembly of DNA Induced by Flexible Binuclear Ruthenium(II)–Polypyridyl Complexes
2016 / Biochemical and Biophysical Research Communications
Recombinant human GM-CSF (rhGM-CSF) from yeast has been clinically applied to immunosuppressed patients. The production of suspension-cultured rice-cell-derived rhGM-CSF (rrhGM-CSF),… Continue reading O-glycans and O-glycosylation sites of recombinant human GM-CSF derived from suspension-cultured rice cells, and their structural role
2016 / Journal of Food Biochemistry
African yam bean (Sphenostylis stenocarpa) seed flour was extracted with 0.5 M NaCl and the supernatant dialyzed against water to… Continue reading Modulation of the secondary and tertiary structures of African yam bean (Sphenostylis stenocarpa) seed globulins, albumins and protein concentrate by pH and NaCl
2016 / Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
The plasma membrane Ca2 + ATPases (PMCA pumps) have a long, cytosolic C-terminal regulatory region where a calmodulin-binding domain (CaM-BD) is located.… Continue reading The ataxia related G1107D mutation of the plasma membrane Ca2 + ATPase isoform 3 affects its interplay with calmodulin and the autoinhibition process
2016 / Journal of Inorganic Biochemistry
With the capability to inhibit the formation of amyloid β peptides (Aβ) fibril, dopamine (DA) and other catechol derivatives have… Continue reading Complicated function of dopamine in Aβ-related neurotoxicity: Dual interactions with Tyr10 and SNK(26–28) of Aβ
2016 / Journal of Photochemistry and Photobiology B: Biology
New chiral reduced Schiff base ligands, L1 and L2 derived from l–/d-histidine and terepthaldehyde, and their Cu(II) and Ni(II) dinuclear complexes 1 & 2 (a and b) were synthesized and thoroughly… Continue reading In vitro DNA binding profile of enantiomeric dinuclear Cu(II)/Ni(II) complexes derived from l–/d–histidine–terepthaldehyde reduced Schiff base as potential chemotherapeutic agents
