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Found 9617 Results / Page 397 of 481

Pathogenic mutations within the disordered palindromic region of the prion protein induce structure therein and accelerate the formation of misfolded oligomers

2016 / Journal of Molecular Biology

Little is understood about how the intrinsically disordered N-terminal region (NTR) of the prion protein modulates its misfolding and aggregation,… Continue reading Pathogenic mutations within the disordered palindromic region of the prion protein induce structure therein and accelerate the formation of misfolded oligomers

Leah Pandiscia, PhD July 28, 2017

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer’s Disease

2016 / Frontiers in Pharmacology

Neuroinflammation is known to have a pivotal role in the pathogenesis of Alzheimer’s disease (AD), and curcumin has been reported… Continue reading Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer’s Disease

Leah Pandiscia, PhD July 28, 2017

Synthesis, characterization, and structure–property investigation of conformationally rigid regioisomers of poly(p-phenylene ethynylene)s

2016 / Journal of Polymer Science Part A: Polymer Chemistry

A series of rigid poly(p-phenylene ethynylene)s (PPE1–PPE4) with biphenyl- (M1–M3) and phenyl- (M4) side groups is prepared from appropriately functionalized… Continue reading Synthesis, characterization, and structure–property investigation of conformationally rigid regioisomers of poly(p-phenylene ethynylene)s

Leah Pandiscia, PhD July 28, 2017

Cephalotanins A–D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons fromCephalotaxus sinensis

2016 / Chemistry A European Journal

Four polycyclic norditerpenoids, cephalotanins A–D (1–4) representing three unprecedented carbon skeletons with highly rigid ring systems, were isolated from Cephalotaxus sinensis and… Continue reading Cephalotanins A–D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons fromCephalotaxus sinensis

Leah Pandiscia, PhD July 28, 2017

Structural Elucidation of the Cell-Penetrating Penetratin Peptide in Model Membranes at the Atomic Level: Probing Hydrophobic Interactions in the Blood–Brain Barrier

2016 / Biochemistry

Cell-penetrating peptides (CPPs) have shown promise in nonpermeable therapeutic drug delivery, because of their ability to transport a variety of… Continue reading Structural Elucidation of the Cell-Penetrating Penetratin Peptide in Model Membranes at the Atomic Level: Probing Hydrophobic Interactions in the Blood–Brain Barrier

Leah Pandiscia, PhD July 28, 2017

Enhancement of the Chaperone Activity of Alkyl Hydroperoxide Reductase C fromPseudomonas aeruginosa PAO1 Resulting from a Point-Specific Mutation Confers Heat Tolerance in Escherichia coli

2016 / Molecules and Cells

Alkyl hydroperoxide reductase subunit C from Pseudomonas aeruginosa PAO1 (PaAhpC) is a member of the 2-Cys peroxiredoxin family. Here, we examined the… Continue reading Enhancement of the Chaperone Activity of Alkyl Hydroperoxide Reductase C fromPseudomonas aeruginosa PAO1 Resulting from a Point-Specific Mutation Confers Heat Tolerance in Escherichia coli

Leah Pandiscia, PhD July 28, 2017

Solution NMR and CD spectroscopy of an intrinsically disordered, peripheral membrane protein: evaluation of aqueous and membrane-mimetic solvent conditions for studying the conformational adaptability of the 18.5 kDa isoform of myelin basic protein (MBP)

2008 / European Biophysics Journal

The stability and secondary structure propensity of recombinant murine 18.5 kDa myelin basic protein (rmMBP, 176 residues) was assessed using circular… Continue reading Solution NMR and CD spectroscopy of an intrinsically disordered, peripheral membrane protein: evaluation of aqueous and membrane-mimetic solvent conditions for studying the conformational adaptability of the 18.5 kDa isoform of myelin basic protein (MBP)

Leah Pandiscia, PhD July 28, 2017
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