Lindbladione (1) is a neural stem cell differentiation activator isolated from Lindbladia tubulina by our group. Hes1 dimerization inhibitory activity… Continue reading Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulina
Carlos Morillo
December 16, 2020
Carlos Morillo
December 16, 2020
Carlos Morillo
January 4, 2021
Dynamic interactions of proteins with lipid membranes are essential regulatory events in biology, but remain rudimentarily understood and particularly overlooked… Continue reading The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity
Carlos Morillo
December 16, 2020
Expansion microscopy (ExM) enables super-resolution imaging of proteins and nucleic acids on conventional microscopes. However, imaging of details of the… Continue reading Nanoscale imaging of bacterial infections by sphingolipid expansion microscopy
Carlos Morillo
December 16, 2020
Nitrous oxide (N2O) is a stratospheric ozone depleting greenhouse gas that has global warming potential. As the catalytic decomposition of… Continue reading N2O decomposition properties of Ru catalysts supported on various oxide materials and SnO2
Carlos Morillo
December 16, 2020
While solar power systems have offered a wide variety of electricity generation approaches including photovoltaics, solar thermal power systems, and… Continue reading Harvesting energy from sun, outer space, and soil
Carlos Morillo
December 16, 2020
Carlos Morillo
December 16, 2020
The use of Target activation-induced cytidine deaminase (Target-AID) base-editing technology with the CRISPR-Cas 9 system fused with activation-induced cytidine deaminase… Continue reading Multiple gene substitution by Target-AID base-editing technology in tomato
Carlos Morillo
December 16, 2020
Downhill folding has been defined as a unique thermodynamic process involving a conformations ensemble that progressively loses structure with the… Continue reading The change of conditions does not affect Ros87 downhill folding mechanism
Carlos Morillo
December 16, 2020
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease
Carlos Morillo
December 16, 2020
Different from molecular level topology, the development of supramolecular topology has been limited due to a lack of reliable synthetic… Continue reading Self-assembled Möbius strips with controlled helicity
Carlos Morillo
December 16, 2020
A novel, expedient and effective methodology for the synthesis of distinctly substituted 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]pyridine and 5,6-dihydrobenzo[h]quinoline systems has been developed with… Continue reading High pressure assisted synthetic approach for novel 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]pyridine and 5,6-dihydrobenzo[h]quinoline derivatives and their assessment as anticancer agents
Carlos Morillo
January 4, 2021
A novel photocatalyst based on the design of P-N heterojunction between hollow spherical Mn3O4 and nanorods shape of α-Ag2WO4 is… Continue reading Rapid reduction of nitroarenes photocatalyzed by an innovative Mn3O4/α-Ag2WO4 nanoparticles
Carlos Morillo
December 16, 2020
γ-valerolactone and γ-caprolactone are commonly used as flavor additives in the food industry. In the present work we fully explore… Continue reading Vibrational Circular Dichroism study of chiral food additives: γ-valero- and γ-caprolactone
Heather Haffner
November 30, 2020
Targeting the interaction between the SARS-CoV-2 Spike protein and the human ACE2 receptor is a promising therapeutic strategy. We designed… Continue reading De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
Heather Haffner
October 30, 2020
Although a lot has been done on the making of antifouling membranes using PEGylated materials, numerous molecular design improvements can… Continue reading Tuning the molecular design of random copolymers for enhancing the biofouling mitigation of membrane materials
Carlos Morillo
October 28, 2020
Carlos Morillo
October 28, 2020
Introduction. The acute kidney injury (AKI) is characterized by a sudden glomerular filtration reduction. Renal or intrinsic causes of AKI… Continue reading Nephroprotective Effect of Embryonic Stem Cells Reducing Lipid Peroxidation in Kidney Injury Induced by Cisplatin
Carlos Morillo
October 28, 2020
Carlos Morillo
October 28, 2020