A simple injectable peptide-based hydrogel of tanshinone ⅡA for antioxidant and anticoagulation

June 29, 2020

Title

A simple injectable peptide-based hydrogel of tanshinone ⅡA for antioxidant and anticoagulation

Year

2020

Journal

Journal of Drug Delivery Science and Technology

Abstract

In this study, the hydrophobic drug Tanshinone ⅡA (Tan ⅡA) as a therapeutic drug was loaded into naphthalene acetic acid-phenylalanine-phenylalanine-glycine hydrogel (Nap-FFG) to construct the supramolecular hydrogels. Nap-FFG hydrogel fibers crosslinked into a network-like structure by self-assembly of polypeptides and then achieved drug loading. The rheological assay of Tan ⅡA-loaded Nap-FFG hydrogel ([email protected]) had excellent shear resistance, allowing it to maintain gel state. Anticoagulant and anti-oxidant assay showed [email protected] hydrogels synergistically resisted hydrogen peroxide damage and inhibited platelet aggregation caused by ADP, which was suitable for the therapy of cardiovascular diseases. In-vitro release assays and in-vivo pharmacokinetic had demonstrated that hydrogels released drugs slowly, reduced drug toxicity, and improved pharmacokinetic behavior. In summary, [email protected] hydrogels was expected to be developed as a novel injection for cardiovascular therapy.

Instrument

J-810

Keywords

Circular dichroism, Secondary structure, Biochemistry, Materials, Pharmaceutical