Title
Antiviral stereoisomers of 3,5-bis(2-hydroxybut-3-en-1-yl)-1,2, 4-thiadiazole from the roots of Isatis indigotica
Author
Ming-Hua Chen, Sheng Lin, Ya-Nan Wang, Cheng-Gen Zhu, Yu-Huan Li, Jian-Dong Jiang, Jian-Gong Shi
Year
2016
Journal
Chinese Chemical Letters
Abstract
Four stereoisomers of 3,5-bis(2-hydroxybut-3-en-1-yl)-1,2,4-thiadiazole, named insatindigothiadiazoles A–D (1a–1d), were isolated from the roots of Isatis indigotica. Their structures were determined by spectroscopic analysis; specifically, the absolute configurations were assigned by using the MPA determination rule based on ΔδRS values of MPA esters, and supported by electronic CD (ECD) calculations. Proposed biosynthetic pathways and preliminary investigations of the biological activities of 1a–1dagainst influenza virus A (H3N2), Coxsackie virus B3, and/or HSV-1 are also discussed.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Medicinal