Title
Blennolide derivatives from the soil-derived fungus Trichoderma asperellum PSU-PSF14
Author
Athip Maha, Patima Phainuphong, Vatcharin Rukachaisirikul, Saowanit Saithong, Souwalak Phongpaichit, Sarinya Hadsadee, Siriporn Jungsuttiwong, Sita Preedanon, Jariya Sakayaroj
Year
2018
Journal
Tetrahedron
Abstract
Three new blennolide derivatives, blennolides L-N (1–3), together with five known metabolites were isolated from the soil-derived fungus Trichoderma asperellum PSU-PSF14. Their structures were determined by analysis of spectroscopic data. Their relative configurations were determined by analysis of NOEDIFF data and confirmed by X-ray crystallography for compound 1 whereas the absolute configurations were established by means of experimental and calculated TDDFT ECD data. Compound 1displayed antifungal activity against Cryptococcus neoformans ATCC90112 and ATCC90113 flucytosine-resistant with the MIC values of 128 and 64 μg/mL, respectively, and was inactive against noncancerous Vero cell lines.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Cotton effect, Natural products