Title
Cytotoxic Lavandulyl Flavanones from Sophora flavescens
Author
Tai-Hyun Kang, Sei-Joon Jeong, Won-Gil Ko, Na-Young Kim, Byung-Hoon Lee, Masanori Inagaki, Tomofumi Miyamoto, Ryuichi Higuchi, Youn-Chul Kim
Year
2000
Journal
Journal of Natural Products
Abstract
Two new lavandulylated flavanones, (2S)-2‘-methoxykurarinone (1) and (−)-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin andl-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1−4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.
Full Article
Instrument
J-720
Keywords
Circular dichroism, Absolute configuration, Pharmaceutical, Natural products