New alkaloidal metabolites from cultures of entomopathogenic fungus Cordyceps takaomontana NBRC 101754
Maichi Hama, Abdelsamed I. Elshamya, Tatsuro Yoneyama, Yusuke Kasai, Hirohumi Yamamoto, Kana Tanigawa, Ayari Oshiro, Masaaki Noji, Sayaka Ban, Hiroshi Imagawa, Akemi Umeyama
Two new alkaloidal metabolites, cordytakaoamides A (1) and B (2), as well as, 2-[(2-hydroxyethyl) amino] benzoic acid (3) and 2E-decenamide (4), and three known compounds (5–7) were isolated from ethyl acetate and n-butanol soluble portions of the entomopathogenic fungus, Cordyceps takaomontana NBRC 101754. Compounds 3 and 4 were isolated here for first time from natural resources. The chemical structures were established depending upon spectroscopic techniques such as 1D, 2D NMR, and HRMS. The absolute configuration of 1 and 2 was elucidated via the total synthesis of 1 as well as the experimental circular dichroism. Compound 3 was confirmed by a signal crystal X-ray analysis.
Circular dichroism, Absolute configuration, Stereochemistry, Agriculture and environmental, Natural products, Pharmaceutical