Novel secoeunicellins produced by an octocoral Cladiella sp
Zhi-Jun Zhang, Yi-Hsuan Wang, Shu-Rong Chen, Bo-Rong Peng, San-Nan Yang, Chiung-Chih Hu, Lee-Shing Fang, Tsong-Long Hwangchi, Ping-Jyun Sung
Two novel 6,7-secoeunicellins, cladieunicellins W (1) and X (2), along with a known eunicellin, klymollin Y (3), were isolated from an octocoral identified as Cladiella sp. The structures of secoeunicellins 1 and 2 were elucidated by spectroscopic methods. 1 is the first secoeunicellin possessing a γ-lactone ring and 2 represents the first secoeunicellin possessing two tetrahydrofuran moieties. Secoeunicellin 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase. These results implied that the methoxy group at C-6 in 2 plays an important role in determining the activity of these compounds.
Circular dichroism, Absolute configuration, Stereochemistry, Agriculture and environmental, Natural products, Pharmaceutical