Sesquiterpenoids from the cultured mycelia of Ganoderma capense
Zhen Tan, Jinlian Zhao, Jimei Liu, Min Zhang, Ridao Chen, Kebo Xie, Jungui Dai
Eleven new sesquiterpenoids, including eight cadinane-type sesquiterpenoids, Ganodermanol A–H (1–8), and three eudesmane-type sesquiterpenoids, Ganodermanol I–K (9–11), together with three known compounds (12–14), were isolated from the cultured mycelia of Ganoderma capense. Their structures and absolute configurations were identified through combined extensive spectroscopic analysis, circular dichroism (CD), and Mo2(AcO)4–induced CD. Compounds 4 and 9 exhibited moderate cytotoxic activity against the human cancer cell line HCT116 with IC50 values of 16.6 and 12.2 μM, respectively.
Circular dichroism, Absolute configuration, Natural products, Medicinal