2022 / Nature Communications
Advances in mechanistic understanding of integrin-mediated adhesion highlight the importance of precise control of ligand presentation in directing cell migration.… Continue reading Control cell migration by engineering integrin ligand assembly
2022 / Nature Communications
African trypanosomes are extracellular pathogens of mammals and are exposed to the adaptive and innate immune systems. Trypanosomes evade the… Continue reading Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor
2022 / Nature Communications
Artificial, synthetic chaperones have attracted much attention in biomedical research due to their ability to control the folding of proteins… Continue reading Multifunctional synthetic nano-chaperone for peptide folding and intracellular delivery
2022 / Nature Communications
The malaria parasite Plasmodium invades a host erythrocyte, multiplies within a parasitophorous vacuole (PV) and then ruptures the PV and… Continue reading Maturation and substrate processing topography of the Plasmodium falciparum invasion/egress protease plasmepsin X
2022 / Nature Communications
The quantitative detection of circularly polarized light (CPL) is necessary in next-generation optical communication carrying high-density information and in phase-controlled… Continue reading Circularly polarized light-sensitive, hot electron transistor with chiral plasmonic nanoparticles
2022 / Nature Communications
The endoplasmic reticulum (ER)-mitochondria contact site (ERMCS) is crucial for exchanging biological molecules such as phospholipids and Ca2+ ions between… Continue reading Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites
2022 / Nature Communications
Recombinant spider silk proteins (spidroins) have multiple potential applications in development of novel biomaterials, but their multimodal and aggregation-prone nature… Continue reading Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform
2022 / Scientific Reports
Acute myeloid leukemia (AML) is a malignant disease of immature myeloid cells and the most prevalent acute leukemia among adults.… Continue reading Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects
2022 / Communication Biology
Autoimmunity develops when extracellular DNA released from dying cells is not cleared from serum. While serum DNA is primarily digested… Continue reading Structural features of Dnase1L3 responsible for serum antigen clearance
2022 / Food Science & Nutrition
Chukrasia tabularis is an economically important tree and widely cultured in the southeast of China. Its barks, leaves, and fruits… Continue reading Bioactivity-guided isolation of anti-inflammatory limonins from Chukrasia tabularis
2022 / Chemistry A European Journal
Construction of lanthanide heterometallic complex is important for engineering multifunction molecular containers. However, it remains a challenge because of the… Continue reading Differentiable Formation of Chiroptical Lanthanide Heterometallic LnnLn’4-n(L6) (n=0–4) Tetrahedra with C2-Symmetrical Bis(tridentate) Ligands
2022 / FEBS Letters
In acidic secretory granules of mammalian cells, peptide hormones including the parathyroid hormone are presumably stored in the form of… Continue reading Heparin promotes rapid fibrillation of the basic parathyroid hormone at physiological pH
2022 / Journal of thrombosis and haemostasis
Deficiency in blood coagulation factor VIII (FVIII) results in life-threating bleeding (hemophilia A) treated by infusions of FVIII concentrates. To… Continue reading Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts
2022 / Protein Science
SARS-CoV-2 may enter target cells through the process of membrane fusion at either the plasma (~pH 7.4–7.0) or endosomal (~pH… Continue reading Exploring the pH dependence of the SARS-CoV-2 complete fusion domain and the role of its unique structural features
2022 / Chem Med Chem
Most antimicrobial peptides (AMPs) and anticancer peptides (ACPs) fold into membrane disruptive cationic amphiphilic α-helices, many of which are however… Continue reading Machine Learning Guided Discovery of Non-Hemolytic Membrane Disruptive Anticancer Peptides
2022 / Scientific Reports
Identification of a protein minimal fragment amenable to crystallisation can be time- and labour intensive especially if large amounts are… Continue reading A multifaceted strategy to improve recombinant expression and structural characterisation of a Trypanosoma invariant surface protein
2022 / Nature Communications
The malaria parasite Plasmodium invades a host erythrocyte, multiplies within a parasitophorous vacuole (PV) and then ruptures the PV and… Continue reading Maturation and substrate processing topography of the Plasmodium falciparum invasion/egress protease plasmepsin X
2022 / Nature Communications
Artificial, synthetic chaperones have attracted much attention in biomedical research due to their ability to control the folding of proteins… Continue reading Multifunctional synthetic nano-chaperone for peptide folding and intracellular delivery
2022 / Nature Communications
Recombinant spider silk proteins (spidroins) have multiple potential applications in development of novel biomaterials, but their multimodal and aggregation-prone nature… Continue reading Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform
2022 / Nature Communications
Thousands of natural products are derived from the fused cyclopentane-pyran molecular scaffold nepetalactol. These natural products are used in an… Continue reading Biocatalytic routes to stereo-divergent iridoids
