2021 / Scientific Report
CGG tandem repeat expansion in the 5′-untranslated region of the fragile X mental retardation-1 (FMR1) gene leads to unusual nucleic …
2021 / Scientific Report
The c subunit is an inner mitochondrial membrane (IMM) protein encoded by three nuclear genes. Best known as an integral …
2021 / Scientific Report
A Bowman–Birk type trypsin inhibitor protein (SSTI) from seeds of the medicinal plant Solanum surattense was isolated, purified and characterized. …
2021 / Communication Biology
Cancer cells are a major source of enzymes that modify collagen to create a stiff, fibrotic tumor stroma. High collagen …
Continue reading “A collagen glucosyltransferase drives lung adenocarcinoma progression in mice”
2021 / ACS Publications JACS Au 2021
A strategy to obtain chiral silica using an achiral stereoregular polymer with polyhedral oligomeric silsesquioxane (POSS) side chains is described …
Continue reading “Chiral Silica with Preferred-Handed Helical Structure via Chiral Transfer”
2021 / Photosynthesis Research (2021)
The core light-harvesting complexes (LH1) in bacteriochlorophyll (BChl) b-containing purple phototrophic bacteria are characterized by a near-infrared absorption maximum around …
2021 / Nature Communications
TRPV4 is a cell surface-expressed calcium-permeable cation channel that mediates cell-specific effects on cellular morphology and function. Dominant missense mutations …
2021 / MDPI
Two new phomaligols, deketo-phomaligol A (1) and phomaligol E (2), together with six known compounds (3–8) were isolated from the …
2021 / Nature Communications
Soluble proteins are universally packed with a hydrophobic core and a polar surface that drive the protein folding process. Yet …
Continue reading “Design of buried charged networks in artificial proteins”
2021 / Nature Communications
The self-assembly of α-synuclein (αS) into intraneuronal inclusion bodies is a key characteristic of Parkinson’s disease. To define the nature …
2021 / Food chemistry
This study aims to evaluate the effect of ultrasonic pretreatment combined with glycation on the structural characteristics and antibacterial activity …
2021 / MDPI
Of the utmost importance of chirality in organic compounds and drugs, the present work reports structure-chirality relationship of three steroidal …
2019 / PLOS ONE
Regulatory agencies establish that a broad physicochemical and biological characterization is necessary for the evaluation of comparability between a biosimilar …
Continue reading “Conformational characterization of a novel anti-HER2 candidate antibody”
2020 / Journal of Pharmaceutical Sciences, RESEARCH ARTICLE DRUG DISCOVERY-DEVELOPMENT INTERFACE| VOLUME 110, ISSUE 2, P707-718, FEBRUARY 01, 2021
Unlipidated outer membrane protein 19 (U-Omp19) is a novel mucosal adjuvant in preclinical development to be used in vaccine formulations. …
Continue reading “Stability Studies of the Vaccine Adjuvant U-Omp19”
2020 / Journal of Pharmaceutical Sciences
Dropping during shipping and handling of liquid biopharmaceutical formulations has long been known to cause protein degradation and aggregation. On …
2021 / Nature Communications
Comparative genomic studies have repeatedly shown that new protein-coding genes can emerge de novo from noncoding DNA. Still unknown is …
2021 / Nature Communications
Protein–protein interactions (PPIs) between modular binding domains and their target peptide motifs are thought to largely depend on the intrinsic …
2021 / Nature Communications, 12, Article number: 1530 (2021)
De novo protein design is advancing rapidly. However, most designs are for single states. Here we report a de novo …
Continue reading “Structural resolution of switchable states of a de novo peptide assembly”
2021 / Nature Communications
Modules that switch protein-protein interactions on and off are essential to develop synthetic biology; for example, to construct orthogonal signaling …
2021 / Nature Communications
Minichromosome maintenance protein 10 (MCM10) is essential for eukaryotic DNA replication. Here, we describe compound heterozygous MCM10 variants in patients …
