2022 / Mol. Pharmaceutics 2022, 19, 7, 2022–2031
Preservation of the integrity of macromolecular higher-order structure is a tenet central to achieving biologic drug and vaccine product stability …
2022 / Scientific Reports
Listeria monocytogenes is a pathogenic bacterium that produces flagella, the locomotory organelles, in a temperature-dependent manner. At 37 °C inside …
2022 / Physiological Reports
Disrupted epithelial barrier, fluid accumulation, inflammation, and compromised physiology are hallmarks of lung injury. Here we investigated the structural stability …
2022 / ChemBioChem
During viral cell entry, the spike protein of SARS-CoV-2 binds to the α1-helix motif of human angiotensin-converting enzyme 2 (ACE2). Thus, …
2022 / Protein Science
Recent studies revealed that molecular events related with the physiology and pathology of αS might be regulated by specific sequence …
2022 / ChemistryOpen
A family of bis[(R or S)-N-1-(Ar)ethylsalicylaldiminato-κ2N,O]-Δ/Λ-zinc(II) {Ar=C6H5 (ZnRL1 or ZnSL1), p-CH3OC6H4 (ZnRL2 or ZnSL2) and p-ClC6H4 (ZnRL3 or ZnSL3)} compounds …
2022 / Nature Cell Biology
Mutagenic purine–pyrimidine repeats can adopt the left-handed Z-DNA conformation. DNA breaks at potential Z-DNA sites can lead to somatic mutations …
2022 / Nature Communications
In flowering plants, strigolactones (SLs) have dual functions as hormones that regulate growth and development, and as rhizosphere signaling molecules …
Continue reading “An ancestral function of strigolactones as symbiotic rhizosphere signals”
2022 / Communications Chemistry
Natural products are well established as an important resource and play an important role in drug discovery. Here, two pyrrolinone-fused …
2022 / Nature Communications
Precise control of morphology and optical response of 3-dimensional chiral nanoparticles remain as a significant challenge. This work demonstrates chiral …
Continue reading “Adenine oligomer directed synthesis of chiral gold nanoparticles”
2022 / Scientific Reports
The emergence of multidrug resistance coupled with shrinking antibiotic pipelines has increased the demand of antimicrobials with novel mechanisms of …
2022 / Scientific Reports
Copper-zinc superoxide dismutase (SOD1) has been proposed as one of the causative proteins of amyotrophic lateral sclerosis (ALS). The accumulation …
2022 / Nature Communications
The endoplasmic reticulum (ER)-mitochondria contact site (ERMCS) is crucial for exchanging biological molecules such as phospholipids and Ca2+ ions between …
2022 / Nature Communications
PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification …
2022 / Nature Communications
ATP-independent chaperones like trigger factor are generally assumed to play passive roles in protein folding by acting as holding chaperones. …
Continue reading “Trigger factor both holds and folds its client proteins”
2022 / Nature Communications
In the literature, organic materials with both aggregation-induced emission (AIE) and aggregation-caused quenching (ACQ) effects that can emit with multiple …
2022 / Nature Communications
DNA methylation is an evolutionarily conserved epigenetic mechanism essential for transposon silencing and heterochromatin assembly. In plants, DNA methylation widely …
Continue reading “Mechanistic basis for maintenance of CHG DNA methylation in plants”
2022 / Advanced Optical Materials
Chirality is a desired property in functional semiconductors for optoelectronic, catalytic, and spintronic applications. Here, introducing enantiomerically-pure 3-aminobutyric acid (3-ABA) …
2022 / Nano Micro small
Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein …
2022 / Protein Science
Parkinson’s disease (PD) is a chronic multifactorial disease, whose etiology is not completely understood. The amyloid aggregation of α-synuclein (Syn) …
