Preservation of the integrity of macromolecular higher-order structure is a tenet central to achieving biologic drug and vaccine product stability …
Continue reading “A Biopharmaceutical Perspective on Higher-Order Structure and Thermal Stability of mRNA Vaccines”
Heather Haffner
July 27, 2022
Listeria monocytogenes is a pathogenic bacterium that produces flagella, the locomotory organelles, in a temperature-dependent manner. At 37 °C inside …
Continue reading “Structural and biochemical analyses of the flagellar expression regulator DegU from Listeria monocytogenes”
Carlos Morillo
July 21, 2022
Carlos Morillo
July 21, 2022
During viral cell entry, the spike protein of SARS-CoV-2 binds to the α1-helix motif of human angiotensin-converting enzyme 2 (ACE2). Thus, …
Continue reading “Synthetic α-Helical Peptides as Potential Inhibitors of the ACE2 SARS-CoV-2 Interaction”
Carlos Morillo
July 21, 2022
Recent studies revealed that molecular events related with the physiology and pathology of αS might be regulated by specific sequence …
Continue reading “Aromaticity at position 39 in α-synuclein: A modulator of amyloid fibril assembly and membrane-bound conformations”
Carlos Morillo
July 21, 2022
Carlos Morillo
July 21, 2022
Mutagenic purine–pyrimidine repeats can adopt the left-handed Z-DNA conformation. DNA breaks at potential Z-DNA sites can lead to somatic mutations …
Continue reading “Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome”
Carlos Morillo
July 21, 2022
In flowering plants, strigolactones (SLs) have dual functions as hormones that regulate growth and development, and as rhizosphere signaling molecules …
Continue reading “An ancestral function of strigolactones as symbiotic rhizosphere signals”
Carlos Morillo
July 21, 2022
Carlos Morillo
July 21, 2022
Precise control of morphology and optical response of 3-dimensional chiral nanoparticles remain as a significant challenge. This work demonstrates chiral …
Continue reading “Adenine oligomer directed synthesis of chiral gold nanoparticles”
Carlos Morillo
July 21, 2022
The emergence of multidrug resistance coupled with shrinking antibiotic pipelines has increased the demand of antimicrobials with novel mechanisms of …
Continue reading “Design, characterization and structure–function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment”
Carlos Morillo
July 21, 2022
Carlos Morillo
July 21, 2022
The endoplasmic reticulum (ER)-mitochondria contact site (ERMCS) is crucial for exchanging biological molecules such as phospholipids and Ca2+ ions between …
Continue reading “Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites”
Carlos Morillo
July 21, 2022
PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification …
Continue reading “Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state”
Carlos Morillo
July 21, 2022
ATP-independent chaperones like trigger factor are generally assumed to play passive roles in protein folding by acting as holding chaperones. …
Continue reading “Trigger factor both holds and folds its client proteins”
Carlos Morillo
July 21, 2022
In the literature, organic materials with both aggregation-induced emission (AIE) and aggregation-caused quenching (ACQ) effects that can emit with multiple …
Continue reading “An unexpected dual-emissive luminogen with tunable aggregation-induced emission and enhanced chiroptical property”
Carlos Morillo
July 21, 2022
DNA methylation is an evolutionarily conserved epigenetic mechanism essential for transposon silencing and heterochromatin assembly. In plants, DNA methylation widely …
Continue reading “Mechanistic basis for maintenance of CHG DNA methylation in plants”
Carlos Morillo
July 21, 2022
Chirality is a desired property in functional semiconductors for optoelectronic, catalytic, and spintronic applications. Here, introducing enantiomerically-pure 3-aminobutyric acid (3-ABA) …
Continue reading “Strong Induced Circular Dichroism in a Hybrid Lead-Halide Semiconductor Using Chiral Amino Acids for Crystallite Surface Functionalization”
Carlos Morillo
June 28, 2022
Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein …
Continue reading “Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination”
Carlos Morillo
June 28, 2022
Carlos Morillo
June 28, 2022