Effects of SPA4 peptide on lipopolysaccharide-disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury

2022 / Physiological Reports

Disrupted epithelial barrier, fluid accumulation, inflammation, and compromised physiology are hallmarks of lung injury. Here we investigated the structural stability …

Carlos Morillo

Characterization of Diastereomeric Equilibria of Pseudotetrahedral Bis[(R or S)-N-1-(Ar)Ethylsalicylaldiminato-κ2N,O]zinc(II) with Λ/Δ-Chirality-At-Metal Induction

2022 / ChemistryOpen

A family of bis[(R or S)-N-1-(Ar)ethylsalicylaldiminato-κ2N,O]-Δ/Λ-zinc(II) {Ar=C6H5 (ZnRL1 or ZnSL1), p-CH3OC6H4 (ZnRL2 or ZnSL2) and p-ClC6H4 (ZnRL3 or ZnSL3)} compounds …

Carlos Morillo

Discovery, total syntheses and potent anti-inflammatory activity of pyrrolinone-fused benzoazepine alkaloids Asperazepanones A and B from Aspergillus candidus

2022 / Communications Chemistry

Natural products are well established as an important resource and play an important role in drug discovery. Here, two pyrrolinone-fused …

Carlos Morillo

Strong Induced Circular Dichroism in a Hybrid Lead-Halide Semiconductor Using Chiral Amino Acids for Crystallite Surface Functionalization

2022 / Advanced Optical Materials

Chirality is a desired property in functional semiconductors for optoelectronic, catalytic, and spintronic applications. Here, introducing enantiomerically-pure 3-aminobutyric acid (3-ABA) …

Carlos Morillo

3,4-Dihydroxyphenylethanol and 3,4-dihydroxyphenylacetic acid affect the aggregation process of E46K variant of α-synuclein at different extent: Insights into the interplay between protein dynamics and catechol effect

2022 / Protein Science

Parkinson’s disease (PD) is a chronic multifactorial disease, whose etiology is not completely understood. The amyloid aggregation of α-synuclein (Syn) …

Carlos Morillo