2018 / Advanced Healthcare Materials
Oral delivery of peptide/protein drugs has attracted worldwide attention due to its good patient compliance and convenience of administration. Orally… Continue reading Protein Corona Liposomes Achieve Efficient Oral Insulin Delivery by Overcoming Mucus and Epithelial Barriers
2018 / molecules
The carbazole ligand 3 was synthesized, characterized and its binding interactions with human telomeric (22HT) G-quadruplex DNA in Na+ and K+-containing buffer were… Continue reading Binding Study of the Fluorescent Carbazole Derivative with Human Telomeric G-Quadruplexes
2018 / Nanoscale
Recent studies have shown that antimicrobial peptides (AMPs) can self-assemble into supramolecular structures, but this has been overlooked as causative… Continue reading Self-assembly dynamics and antimicrobial activity of all L- and D-amino acid enantiomers of a designer peptide
2019 / Phytochemistry Letters
Two new Lycopodium alkaloids, phlenumdines D (1) and E (2), have been isolated from the club moss Phlegmariurus nummulariifolius (Blume) Ching along with ten… Continue reading Phlenumdines D and E, new Lycopodium alkaloids from Phlegmariurus nummulariifolius, and their regulatory effects on macrophage differentiation during tumor development
2019 / Biochemistry and Biophysics Reports
We tested whether a short model peptide derived from a group 3 late embryogenesisabundant (G3LEA) protein is able to maintain the fluorescence activity… Continue reading A LEA model peptide protects the function of a red fluorescent protein in the dry state
2019 / Biochemical and Biophysical Research Communications
The effect on protein conformation and thermal stability was studied for β-Galactosidase (β-Gal) encapsulated in the nanopores of a silicate matrix (Eβ-Gal). Circular dichroism spectra showed that, compared… Continue reading β-sheet to α-helix conversion and thermal stability of β-Galactosidase encapsulated in a nanoporous silica gel
2018 / Journal of Medicinal Chemistry
Here we describe the three-dimensional structure and antimicrobial mechanism of mBjAMP1, an antimicrobial peptide (AMP) isolated from Branchiostoma japonicum. The structure… Continue reading Structural and Functional Assessment of mBjAMP1, an Antimicrobial Peptide from Branchiostoma japonicum, Revealed a Novel α-Hairpinin-like Scaffold with Membrane Permeable and DNA Binding Activity
2018 / Biomacromolecules
The size control of nanomedicines for tumor diagnosis and therapy is of high importance, since it enables or disables deep… Continue reading Impact of Branching on the Solution Behavior and Serum Stability of Starlike Block Copolymers
2019 / RSC Advances
μ-Conotoxin PIIIA, a peptide toxin isolated from Conus purpurascens, blocks the skeletal muscle voltage-gated sodium channel NaV1.4 with significant potency. PIIIA… Continue reading Role of the disulfide bond on the structure and activity of μ-conotoxin PIIIA in the inhibition of NaV1.4
2019 / Solid State Nuclear Magnetic Resonance
Cellulose nanocrystal films with either disordered or chiral nematic structures of varying helical pitch were investigated using 23Na solid-state nuclear magnetic resonance (NMR)… Continue reading Solid-state 23Na NMR spectroscopy studies of ordered and disordered cellulose nanocrystal films
2019 / Phytochemistry Letters
Two new bisabolane-type sesquiterpenoids, (3R,4S,5R,7S)-3,4,5-trihydroxybisabola-10-ene-9-one (1), (1R,2S,5R,7R,8S)-2,8-epoxy-5-hydroxybisabola-3,10-diene-9-one (2), together with seven known anologues (3–9), were isolated from the cooking liquid… Continue reading Two new bisabolane-type sesquiterpenoids from the cooking liquid of Curcuma longa rhizomes
2018 / ACS Applied Polymer Materials
A new highly conjugated polymer–bioconjugate poly[9,9-bis(6′-adenine) hexyl)fluorene-co-4,7-(2,1,3 benzothiadiazole)] (PFBT-A) is developed using the well-known Pd(PPh3)4-catalyzed Suzuki cross-coupling polymerization reaction with… Continue reading Polyfluorene-Based Bioconjugates for Selective Detection of Ferritin in Normal and Cancer Human Blood Serums
2018 / Nucleic Acids Research
Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in… Continue reading Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter
2018 / BMC Research Notes
Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases, often referred as prion diseases. TSEs result from the… Continue reading Preparation of lyophilized recombinant prion protein for TSE diagnosis by RT-QuIC
2018 / Nature Communications
Polypeptides have broad applications and can be prepared via ring-opening polymerization of α-amino acid N-carboxyanhydrides (NCAs). Conventional initiators, such as primary amines,… Continue reading Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
2018 / Soft Matter
The generally poor mechanical stability of hydrogels limits their use as functional materials for many biomedical applications. In this work,… Continue reading Poly(vinyl alcohol)-induced thixotropy of an L-carnosine-based cytocompatible, tripeptidic hydrogel
2019 / Food Packaging and Shelf Life
Fabrication of fish gelatin nanofilms was realized by electrospinning using low concentrations of acetic acid, malic acid and citric acid… Continue reading Study of electrospun fish gelatin nanofilms from benign organic acids as solvents
2018 / Scientific Reports
Cell death-inducing DFF45-like effect (CIDE) domain-containing proteins, DFF40, DFF45, CIDE-A, CIDE-B, and FSP27, play important roles in apoptotic DNA fragmentation… Continue reading Crystal structure and mutation analysis revealed that DREP2 CIDE forms a filament-like structure with features differing from those of DREP4 CIDE
2018 / BMC Technology
Proteins in inclusion bodies (IBs) present native-like secondary structures. However, chaotropic agents at denaturing concentrations, which are widely used for… Continue reading Association of high pressure and alkaline condition for solubilization of inclusion bodies and refolding of the NS1 protein from zika virus
2018 / The Journal of Organic Chemistry
As an effort to integrate natural products chemistry and coordination chemistry, a diastereomeric pair of chiral alkaloidal manifolds composed of… Continue reading Chiroptical Inversion of Europium(III) Complexes by Changing a Remote Stereogenic Center of a C2-Symmetric Bispyrrolidinoindoline Manifold
