2022 / Nature Communications
The human pathogen Mycobacterium tuberculosis requires a P1B-ATPase metal exporter, CtpC (Rv3270), for resistance to zinc poisoning. Here, we show… Continue reading Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms
2022 / Nature Communications
Peptidomimetic polymers have attracted increasing interest because of the advantages of facile synthesis, high molecular tunability, resistance to degradation, and… Continue reading Intrinsically fluorescent polyureas toward conformation-assisted metamorphosis, discoloration and intracellular drug delivery
2022 / Communications Biology
Allergies have become a rising health problem, where plentiful substances can trigger IgE-mediated allergies in humans. While profilins are considered… Continue reading A native IgE in complex with profilin provides insights into allergen recognition and cross-reactivity
2022 / Scientific reports
There is an urgent need to validate new drug targets and identify small molecules that possess activity against both drug-resistant… Continue reading Identification of small molecules targeting homoserine acetyl transferase from Mycobacterium tuberculosis and Staphylococcus aureus
2022 / Communications Biology
Proteomic, cellular and biochemical analysis of the stress protein NUPR1 reveals that it binds to PARP1 into the nucleus and… Continue reading NUPR1 protects against hyperPARylation-dependent cell death
2022 / Communications Biology
Multidomain kinases use many ways to integrate and process diverse stimuli. Here, we investigated the mechanism by which the protein… Continue reading PYK2 senses calcium through a disordered dimerization and calmodulin-binding element
2022 / Mol. Pharmaceutics 2022, 19, 7, 2022–2031
Preservation of the integrity of macromolecular higher-order structure is a tenet central to achieving biologic drug and vaccine product stability… Continue reading A Biopharmaceutical Perspective on Higher-Order Structure and Thermal Stability of mRNA Vaccines
2022 / Scientific Reports
Listeria monocytogenes is a pathogenic bacterium that produces flagella, the locomotory organelles, in a temperature-dependent manner. At 37 °C inside… Continue reading Structural and biochemical analyses of the flagellar expression regulator DegU from Listeria monocytogenes
2022 / Physiological Reports
Disrupted epithelial barrier, fluid accumulation, inflammation, and compromised physiology are hallmarks of lung injury. Here we investigated the structural stability… Continue reading Effects of SPA4 peptide on lipopolysaccharide-disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury
2022 / ChemBioChem
During viral cell entry, the spike protein of SARS-CoV-2 binds to the α1-helix motif of human angiotensin-converting enzyme 2 (ACE2). Thus,… Continue reading Synthetic α-Helical Peptides as Potential Inhibitors of the ACE2 SARS-CoV-2 Interaction
2022 / Protein Science
Recent studies revealed that molecular events related with the physiology and pathology of αS might be regulated by specific sequence… Continue reading Aromaticity at position 39 in α-synuclein: A modulator of amyloid fibril assembly and membrane-bound conformations
2022 / ChemistryOpen
A family of bis[(R or S)-N-1-(Ar)ethylsalicylaldiminato-κ2N,O]-Δ/Λ-zinc(II) {Ar=C6H5 (ZnRL1 or ZnSL1), p-CH3OC6H4 (ZnRL2 or ZnSL2) and p-ClC6H4 (ZnRL3 or ZnSL3)} compounds… Continue reading Characterization of Diastereomeric Equilibria of Pseudotetrahedral Bis[(R or S)-N-1-(Ar)Ethylsalicylaldiminato-κ2N,O]zinc(II) with Λ/Δ-Chirality-At-Metal Induction
2022 / Nature Communications
The endoplasmic reticulum (ER)-mitochondria contact site (ERMCS) is crucial for exchanging biological molecules such as phospholipids and Ca2+ ions between… Continue reading Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites
2022 / Nature Communications
PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification… Continue reading Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
2022 / Nature Communications
ATP-independent chaperones like trigger factor are generally assumed to play passive roles in protein folding by acting as holding chaperones.… Continue reading Trigger factor both holds and folds its client proteins
2022 / Nature Communications
In the literature, organic materials with both aggregation-induced emission (AIE) and aggregation-caused quenching (ACQ) effects that can emit with multiple… Continue reading An unexpected dual-emissive luminogen with tunable aggregation-induced emission and enhanced chiroptical property
2022 / Nature Communications
DNA methylation is an evolutionarily conserved epigenetic mechanism essential for transposon silencing and heterochromatin assembly. In plants, DNA methylation widely… Continue reading Mechanistic basis for maintenance of CHG DNA methylation in plants
2022 / Nature Cell Biology
Mutagenic purine–pyrimidine repeats can adopt the left-handed Z-DNA conformation. DNA breaks at potential Z-DNA sites can lead to somatic mutations… Continue reading Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome
2022 / Nature Communications
In flowering plants, strigolactones (SLs) have dual functions as hormones that regulate growth and development, and as rhizosphere signaling molecules… Continue reading An ancestral function of strigolactones as symbiotic rhizosphere signals
2022 / Communications Chemistry
Natural products are well established as an important resource and play an important role in drug discovery. Here, two pyrrolinone-fused… Continue reading Discovery, total syntheses and potent anti-inflammatory activity of pyrrolinone-fused benzoazepine alkaloids Asperazepanones A and B from Aspergillus candidus
