2022 / Journal of Food Science
Wild jujube seed protein (WJSP) as one kind of functional food material has attracted much attention due to its highly… Continue reading Physico-chemical properties, antioxidant activity, and ACE inhibitory activity of protein hydrolysates from wild jujube seed
2022 / Structural Biology
In this work, we provide an in-depth structural analysis of SmeCOSe together with the first ligand-bound structures of this enzyme,… Continue reading Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding
2022 / ADVANCED MATERIALS
The development of simple and accurate methods to predict mutations in proteins remains an unsolved challenge in modern biochemistry. It… Continue reading Deep-Learning-Assisted Stratification of Amyloid Beta Mutants Using Drying Droplet Patterns
2022 / Communications Biology
Amyloid-β (Aβ) and semen-derived enhancer of viral infection (SEVI) are considered as the two causative proteins for central pathogenic cause… Continue reading Cross-seeding between Aβ and SEVI indicates a pathogenic link and gender difference between alzheimer diseases and AIDS
2022 / Scientific reports
A clinically relevant inhibitor for Heptosyltransferase I (HepI) has been sought after for many years because of its critical role… Continue reading Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action
2022 / Nature Communications
Parkinson’s disease (PD) is a progressive neurodegenerative disorder for which there is no successful prevention or intervention. The pathological hallmark… Continue reading Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly
2022 / Nature plants
Alternative splicing is central to metazoan gene regulation, but the regulatory mechanisms are incompletely understood. Here, we show that G-quadruplex… Continue reading Alternative splicing modulation by G-quadruplexes
2022 / Nature Communications
In nature as in biotechnology, light-oxygen-voltage photoreceptors perceive blue light to elicit spatiotemporally defined cellular responses. Photon absorption drives thioadduct… Continue reading Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine
2022 / Nature Plants
To date, little is known about the evolution of fern genomes, with only two small genomes published from the heterosporous… Continue reading The flying spider-monkey tree fern genome provides insights into fern evolution and arborescence
2022 / Scientific reports
Human group IIA secreted phospholipase A2 (GIIA) is a key enzyme in inflammatory reactions, worsening the condition of several chronic… Continue reading Group IIA secreted phospholipase A2 inhibition by elemolic acid as a function of anti-inflammatory activity
2022 / Scientific reports
Aggregation of α-synuclein (α-syn) into amyloid fibrils is closely associated with Parkinson’s disease (PD). Familial mutations or posttranslational truncations in… Continue reading Mechanisms of enhanced aggregation and fibril formation of Parkinson’s disease-related variants of α-synuclein
2022 / Communications Biology
Organisms have a myriad of strategies for sensing, responding to, and combating reactive oxygen species, which are unavoidable consequences of… Continue reading Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT
2022 / PROTEINS
The cone-rod homeobox (CRX) protein is a critical K50 homeodomain transcription factor responsible for the differentiation and maintenance of photoreceptor… Continue reading Structural and functional analysis of the human cone-rod homeobox transcription factor
2022 / Nature Communications
The canonical double helical π-stacked array of base pairs within DNA interior has inspired the interest in supramolecular double helical… Continue reading Double helical π-aggregate nanoarchitectonics for amplified circularly polarized luminescence
2022 / Nature Communications
Guest capture and release are important properties of self-assembling nanostructures. Over time, a significant fraction of guests might engage in… Continue reading Hyper-CEST NMR of metal organic polyhedral cages reveals hidden diastereomers with diverse guest exchange kinetics
2022 / Nature Communications
Complement activation on cell surfaces leads to the massive deposition of C3b, iC3b, and C3dg, the main complement opsonins. Recognition… Continue reading The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor
2022 / Nature Communications
Homochirality is a fundamental feature of living systems, and its origin is still an unsolved mystery. Previous investigations showed that… Continue reading Chirality transfer from a 3D macro shape to the molecular level by controlling asymmetric secondary flows
2022 / Light: Science & Applications
Carbon dots (CDs) are light-emitting nanoparticles that show great promise for applications in biology and medicine due to the ease… Continue reading Revealing the nature of optical activity in carbon dots produced from different chiral precursor molecules
2022 / Scientific reports
Modern biology investigations on phytochromes as near-infrared fluorescent pigments pave the way for the development of new biosensors, as well… Continue reading Improved fluorescent phytochromes for in situ imaging
2022 / Communications Biology
Evolution of proteins is constrained by their structure and function. While there is a consensus that the plasticity of intrinsically… Continue reading The dynamic properties of a nuclear coactivator binding domain are evolutionarily conserved
