2022 / Communications Biology
The role of dimer formation for the onset of catalytic activity of SARS-CoV-2 main protease (MProWT) was assessed using a… Continue reading Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor
2022 / Scientific Reports
Parkinson’s disease (PD) is a neurodegenerative condition featured by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein… Continue reading Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent
2022 / Nature Communications
The task of protein sequence design is central to nearly all rational protein engineering problems, and enormous effort has gone… Continue reading Protein sequence design with a learned potential
2022 / NPG Asia Materials
Spin tunability by circularly polarized photons occurs in an unconnected method, providing more spaces to design memory devices. Here, by… Continue reading Control of the conversion between circularly polarized photons and spin by introducing chiral orbit in organic complexes
2022 / FEBS Letters
Calmodulin is a conserved calcium signalling protein that regulates a wide range of cellular functions. Amino-terminal acetylation is a ubiquitous… Continue reading Acetylation stabilises calmodulin-regulated calcium signalling
2022 / Scientific Reports
Plants have served for centuries as sources of compounds useful for human health such as antioxidant, anti-diabetic and antitumor agents.… Continue reading Hippophae rhamnoides L. leaf and twig extracts as rich sources of nutrients and bioactive compounds with antioxidant activity
2022 / ChemistryOpen
Nucleic acid quadruplexes are proposed to play a role in the regulation of gene expression, are often present in aptamers… Continue reading A Chimeric DNA/RNA Antiparallel Quadruplex with Improved Stability
2022 / ChemBioChem
During evolution of an RNA world, the development of enzymatic function was essential. Such enzymatic function was linked to RNA… Continue reading Mapping the Conformational Landscape of the Neutral Network of RNA Sequences That Connect Two Functional Distinctly Different Ribozymes
2022 / FASEB Journal
Spike trimer plays a key role in SARS-CoV-2 infection and vaccine development. It consists of a globular head and a… Continue reading Structural polymorphism of coiled-coils from the stalk domain of SARS-CoV-2 spike protein
2022 / PROTEIN SCIENCE
Linker histone H1 (H1) is an abundant chromatin-binding protein that acts as an epigenetic regulator binding to nucleosomes and altering… Continue reading Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges
2022 / Nature Communications
V2p and V2i antibodies (Abs) that are specific for epitopes in the V1V2 region of the HIV gp120 envelope (Env)… Continue reading Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines
2022 / Communications Biology
Aggregation of the 140-residue protein α-synuclein (αSN) is a key factor in the etiology of Parkinson’s disease. Although the intensely… Continue reading The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization
2022 / Scientific Reports
Superoxide dismutases are important group of antioxidant metallozyme and play important role in ROS homeostasis in salinity stress. The present… Continue reading Comprehensive characterization and molecular insights into the salt tolerance of a Cu, Zn-superoxide dismutase from an Indian Mangrove, Avicennia marina
2022 / Scientific Reports
Resveratrol is a polyphenol belonging to the class stilbenes. The active and stable form of resveratrol is trans-resveratrol. This polyphenol… Continue reading Investigating binding dynamics of trans resveratrol to HSA for an efficient displacement of aflatoxin B1 using spectroscopy and molecular simulation
2022 / Scientific Reports
Recent structural studies of β-III-spectrin and related cytoskeletal proteins revealed N-terminal sequences that directly bind actin. These sequences are variable… Continue reading β-III-spectrin N-terminus is required for high-affinity actin binding and SCA5 neurotoxicity
2022 / Nature Communications
We report the discovery of a facile peptide macrocyclization and stapling strategy based on a fluorine thiol displacement reaction (FTDR),… Continue reading Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction
2022 / Nature Communications
Circularly polarized organic afterglow (CPOA) with both long-lived room-temperature phosphorescence (RTP) and circularly polarized luminescence (CPL) is currently attracting great… Continue reading Single-component color-tunable circularly polarized organic afterglow through chiral clusterization
2022 / Nature Communications
The collagenases of Vibrio species, many of which are pathogens, have been regarded as an important virulence factor. However, there… Continue reading Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis
2022 / Nature Communications
We report the discovery of a facile peptide macrocyclization and stapling strategy based on a fluorine thiol displacement reaction (FTDR),… Continue reading Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction
2022 / Nature Communications
Real-time imaging of the tumour boundary is important during surgery to ensure that sufficient tumour tissue has been removed. However,… Continue reading A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging
