2021 / FEBS Journal
ZAG is a multifunctional glycoprotein with a class I MHC-like protein fold and an α1-α2 lipid-binding groove. The intrinsic ZAG… Continue reading Identification of diverse lipid-binding modes in the groove of zinc α2 glycoprotein reveals its functional versatility
2021 / European Journal of Organic Chemistry
Chiral scaffolds have been synthesized through selective transformations from conveniently protected cyclobutane β-amino acids. The obtained derivatives present additional functional… Continue reading Synthesis of Chiral Scaffolds Based on Polyfunctional Cyclobutane β-Amino Acids
2021 / Journal of Veterinary Pharmacology and Therapeutics
Cardiovascular diseases (CVDs) like hypertension are a major cause for death worldwide. In the cardiovascular tissue, the endothelin system—consisting of… Continue reading Doxycycline pharmacokinetics in geese
2021 / ChemCioChem
Selective switching of enzymatic activity has been a longstanding goal in synthetic biology. Drastic changes in activity upon mutational manipulation… Continue reading Controlling Enzymatic Activity by Modulating the Oligomerization State via Chemical Rescue and Optical Control
2021 / ChemMedChem
The interaction of metallodrugs with proteins influences their mechanism of action and side effects. In the case of platinum drugs,… Continue reading Interaction of Copper Trafficking Proteins with the Platinum Anticancer Drug Kiteplatin
2021 / Chemistry A European Journal
Canonical G-quadruplexes can adopt a variety of different topologies depending on the arrangement of propeller, lateral, or diagonal loops connecting… Continue reading Expanding the Topological Landscape by a G-Column Flip of a Parallel G-Quadruplex
2021 / Engineering in Life Science
Inserting foreign epitopes to hepatitis B core (HBc) virus-like particles (VLPs) could influence the molecular conformation and therefore vary the… Continue reading Cost-effective purification process development for chimeric hepatitis B core (HBc) virus-like particles assisted by molecular dynamic simulation
2021 / PROTEIN SCIENCE
Intrinsically disordered proteins (IDPs) regularly constitute components of larger protein assemblies contributing to architectural stability. Two small, highly acidic IDPs… Continue reading The disordered PCI-binding human proteins CSNAP and DSS1 have diverged in structure and function
2021 / PROTEIN SCIENCE
Protein stability can be fine-tuned by modifying different structural features such as hydrogen-bond networks, salt bridges, hydrophobic cores, or disulfide… Continue reading A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels
2021 / ChemSusChem
Mechanochemistry is a versatile methodology that can be employed both for covalent bond formation in organic synthesis as well as… Continue reading Mechanochemical Preparation of Protein : hydantoin Hybrids and Their Release Properties
2021 / Journal of Inherited Hearbolic Disease
Isolated sulfite oxidase deficiency (ISOD) is a rare recessive and infantile lethal metabolic disorder, which is caused by functional loss… Continue reading A defect in molybdenum cofactor binding causes an attenuated form of sulfite oxidase deficiency
2021 / Macro-Molecular Rapid Communications
The combination of complementary, noncovalent interactions is a key principle for the design of multistimuli responsive hydrogels. In this work,… Continue reading Bridging Rigidity and Flexibility: Modulation of Supramolecular Hydrogels by Metal Complexation
2021 / Chemistry A European Journal
Peptide-based hydrogels, originated by multiscale self-assembling phenomenon, have been proposed as multivalent tools in different technological areas. Structural studies and… Continue reading The Introduction of a Cysteine Residue Modulates The Mechanical Properties of Aromatic-Based Solid Aggregates and Self-Supporting Hydrogels
2021 / Small methods
With increasing interest in applying recombinant monoclonal antibodies (mAbs) in human medicine, engineered mAb fragments with reduced size and improved… Continue reading Design of a Novel Fab-Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use
2021 / CHEMISTRY & BIODIVERSITY
The C-3 phenolic hydroxy group containing morphine derivatives (morphine, oxymorphone, naloxone, naltrexone) are excellent candidates for the synthesis of 3-O-functionalized… Continue reading Synthesis of 3-O-Carboxyalkyl Morphine Derivatives and Characterization of Their Acid-Base Properties
2021 / ChemBioChem
C4-substituted fluoroprolines (4R)-fluoroproline ((4R)-Flp) and (4S)-fluoroproline ((4S)-Flp) have been used in protein engineering to enhance the thermodynamic stability of peptides… Continue reading Protein Design with Fluoroprolines: 4,4-Difluoroproline Does Not Eliminate the Rate-Limiting Step of Thioredoxin Folding
2021 / Chemistry A European Journal
A stereogenic π-system based on dimer (2) and trimer (3) of [2.2]paracyclophane (PC) and biphenyl was prepared and its structural,… Continue reading Helical Oligophenylene Linked with [2.2]Paracyclophane: Stereogenic π-Conjugated Dye for Highly Emissive Chiroptical Properties
2021 / CHEMISTRY & BIODIVERSITY
The reduced derivative of α-conotoxin MI, a 14 amino acid peptide is characterized by NMR-pH titrations and molecular dynamics simulations… Continue reading Solution Structure and Acid-Base Properties of Reduced α-Conotoxin MI
2021 / ChemBioChem
With the emergence of novel viruses, the development of new antivirals is more urgent than ever. A key step in… Continue reading Systematic Evaluation of Fluorination as Modification for Peptide-Based Fusion Inhibitors against HIV-1 Infection
2021 / Engineering
SARS-CoV-2 is responsible for a disruptive worldwide viral pandemic, and renders a severe respiratory disease known as COVID-19. Spike protein… Continue reading Purification and characterization of the receptor-binding domain of SARS-CoV-2 spike protein from Escherichia coli
