2021 / Nature Communications
In antibody light chain (AL) amyloidosis, overproduced light chain (LC) fragments accumulate as fibrils in organs and tissues of patients.… Continue reading Dissection of the amyloid formation pathway in AL amyloidosis
2021 / Nature Communications
During injured tissue regeneration, the extracellular matrix plays a key role in controlling and coordinating various cellular events by binding… Continue reading Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration
2021 / Nature Communications
Rhizobium etli, a nitrogen-fixing bacterial symbiont of legume plants, encodes an essential l-asparaginase (ReAV) with no sequence homology to known… Continue reading Crystal structures of the elusive Rhizobium etli l-asparaginase reveal a peculiar active site
2021 / Nature Communications
Antibodies bind antigens via flexible loops called complementarity-determining regions (CDRs). These are usually 6-20 residues long. However, some bovine antibodies… Continue reading Mechanistic principles of an ultra-long bovine CDR reveal strategies for antibody design
2021 / Scientific Reports
Sweet taste perception is mediated by a heterodimeric receptor formed by the assembly of the TAS1R2 and TAS1R3 subunits. TAS1R2… Continue reading Biophysical and functional characterization of the human TAS1R2 sweet taste receptor overexpressed in a HEK293S inducible cell line
2021 / Scientific Reports
α-Conotoxins are small disulfide-rich peptides targeting nicotinic acetylcholine receptors (nAChRs) characterised by a CICII-Xm-CIII-Xn-CIV framework that invariably adopt the native… Continue reading Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA
2021 / Cell Death & Diffirentiation
Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the endoplasmic reticulum, where they impact Ca2+ dynamics by… Continue reading Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
2021 / Communications Biology
Plasmodium falciparum-infected erythrocytes (IE) sequester in the placenta via surface protein VAR2CSA, which binds chondroitin sulfate A (CSA) expressed on… Continue reading Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
2021 / Scientific Reports
In recent times, fused azaheterocycles emerged as impressive therapeutic agents. Binding studies of such azaheterocycles with biomolecules is an important… Continue reading Visible-light driven regioselective synthesis, characterization and binding studies of 2-aroyl-3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidines with DNA and BSA using biophysical and computational techniques
2021 / Scientific Reports
Self-regulated “smart” insulin administration system that mimic pancreatic endocrine function would be highly desirable for diabetes management. Here, a glucose-responsive… Continue reading Insulin smart drug delivery nanoparticles of aminophenylboronic acid–POSS molecule at neutral pH
2021 / Electronic Journal of Biothechnology
Opsonization, is the molecular mechanism by which target molecules promote interactions with phagocyte cell surface receptors to remove unwanted cells… Continue reading An in vitro model mimicking the complement system to favor directed phagocytosis of unwanted cells
2021 / Chirality
The application of the exciton chirality method (ECM) to interpret electronic circular dichroism (ECD) spectra is a well-established and still… Continue reading ECD exciton chirality method today: a modern tool for determining absolute configurations
2021 / Nature Communications
The microtubule-associated protein tau is implicated in the formation of oligomers and fibrillar aggregates that evade proteostasis control and spread… Continue reading Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
2021 / Scientific reports
The cellular prion protein (PrPC) is a mainly α-helical 208-residue protein located in the pre- and postsynaptic membranes. For unknown… Continue reading Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein
2021 / Cell Death & Differenitation
Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the endoplasmic reticulum, where they impact Ca2+ dynamics by… Continue reading Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
2021 / Scientific reports
The site selectivity for lysine conjugation on a native protein is difficult to control and characterize. Here, we applied mass… Continue reading Selective and predicable amine conjugation sites by kinetic characterization under excess reagents
2021 / Scientific reports
The structures of a cyanophage small heat shock protein (sHSP) were determined as octahedrons of 24-mers and 48-mers and as… Continue reading Multiple nanocages of a cyanophage small heat shock protein with icosahedral and octahedral symmetries
2021 / Scientific reports
Self-regulated “smart” insulin administration system that mimic pancreatic endocrine function would be highly desirable for diabetes management. Here, a glucose-responsive… Continue reading Insulin smart drug delivery nanoparticles of aminophenylboronic acid–POSS molecule at neutral pH
2021 / Nature Communications
Expanding the useful lifespan of materials is becoming highly desirable, and self-healing and self-repairing materials may become valuable commodities. The… Continue reading Redox-responsive self-healing materials formed from host–guest polymers
2021 / Scientific reports
Anhydrobiosis, one of the most extensively studied forms of cryptobiosis, is induced in certain organisms as a response to desiccation.… Continue reading Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade
