2021 / Nature Microbiology
Self-assembling peptides have shown tremendous potential in the fields of material sciences, nanoscience, and medicine. Because of the vast combinatorial… Continue reading Rapid discovery of self-assembling peptides with one-bead one-compound peptide library
2021 / Scientific reports
Flotillins are the major structural proteins in erythroid raft domains. We have shown previously that the dynamic nanoscale organization of… Continue reading Molecular characterization of direct interactions between MPP1 and flotillins
2021 / Scientific reports
Human mitochondrial chaperonin mHsp60 is essential for mitochondrial function by assisting folding of mitochondrial proteins. Unlike the double-ring bacterial GroEL,… Continue reading Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60
2021 / Fitoterapia
Four previously unreported sesquiterpenoid diasteromers, arteannoides U–X (1–4), together with one new norsesquiterpenoid 5 (arteannoide Y) and one undescribed rearranged… Continue reading Arteannoides U–Z: Six undescribed sesquiterpenoids with anti-inflammatory activities from the aerial parts of Artemisia annua (Qinghao)
2021 / Fitoterapia
The first phytochemical investigation from the stems of Croton krabas resulted in the isolation of three new ent-clerodane diterpenoids, crotonkrabases… Continue reading ent-Clerodane diterpenoids from the stems of Croton krabas
2021 / Chemistry Letters, 2021, Volume 50, Issue 2
A wide variety of synthetic molecular machines has been designed and synthesized to construct nanometer-scale assemblies whose molecular motions can… Continue reading Stimuli-responsive Molecular Springs Based on Single- and Multi-stranded Helical Structures
2021 / Nucleic Acids Research
Rational design of aptamers to incorporate unnatural nucleotides and special chemical moieties can expand their functional complexity and diversity. Spiegelmer… Continue reading Circular L-RNA aptamer promotes target recognition and controls gene activity
2021 / Nature Communications
We previously elucidated principles for designing ideal proteins with completely consistent local and non-local interactions which have enabled the design… Continue reading Role of backbone strain in de novo design of complex α/β protein structures
2021 / Nature Communications
In living organisms, proteins are organized prevalently through a self-association mechanism to form dimers and oligomers, which often confer new… Continue reading Dimerization and oligomerization of DNA-assembled building blocks for controlled multi-motion in high-order architectures
2021 / Scientific reports
Generally, intermolecular disulfide bond contribute to the conformational protein stability. To identify sites where intermolecular disulfide bond can be introduced… Continue reading A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab
2021 / Scientific reports
Sequence variants (SV) in protein bio therapeutics can be categorized as unwanted impurities and may raise serious concerns in efficacy… Continue reading Identification, characterization and control of a sequence variant in monoclonal antibody drug product: a case study
2021 / Scientific Report
Optically active fullerenes, including C60 and C70 derivatives carrying organic substituents, are used in a range of applications because of… Continue reading Deep-red circularly polarised luminescent C70 derivatives
2021 / Nature Communications
α-Synuclein aggregation is a key driver of neurodegeneration in Parkinson’s disease and related syndromes. Accordingly, obtaining a molecule that targets… Continue reading α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
2021 / Nature Communications
Membrane contact sites (MCS) are subcellular regions where two organelles appose their membranes to exchange small molecules, including lipids. Structural… Continue reading Nanoscale architecture of a VAP-A-OSBP tethering complex at membrane contact sites
2021 / Nature Communications
De novo designed self-assembling peptides (SAPs) are promising building blocks of supramolecular biomaterials, which can fulfill a wide range of… Continue reading Intracellular artificial supramolecules based on de novo designed Y15 peptides
2021 / Nature Communications
Partially unfolded alpha-lactalbumin forms the oleic acid complex HAMLET, with potent tumoricidal activity. Here we define a peptide-based molecular approach… Continue reading Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex
2021 / Nature Communications
Decoding the role of histone posttranslational modifications (PTMs) is key to understand the fundamental process of epigenetic regulation. This is… Continue reading Site-specific ubiquitylation acts as a regulator of linker histone H
2021 / Scientific Report
Unconjugated bilirubin (UCB) is the end-product of heme catabolism in the intravascular compartment. Although beneficial for human health when mildly… Continue reading Physico-chemical characterization of bilirubin-10-sulfonate and comparison of its acid–base behavior with unconjugated bilirubin
2021 / Scientific Report
Acyl-ACP reductase (AAR) is one of the two key cyanobacterial enzymes along with aldehyde deformylating oxygenase (ADO) involved in the… Continue reading Biophysical and structural studies reveal marginal stability of a crucial hydrocarbon biosynthetic enzyme acyl ACP reductase
2021 / Scientific Report
Telomerase RNA (TR) carries the template for synthesis of telomere DNA and provides a scaffold for telomerase assembly. Fungal TRs… Continue reading Extraordinary diversity of telomeres, telomerase RNAs and their template regions in Saccharomycetaceae
