Circular Dichroism Archives

Impact of pH on the interaction between soybean protein isolate and oxidized bacterial cellulose at oil-water interface: Dilatational rheological and emulsifying properties

2021 / Food Hydrocolloids

The utilizations of the complexes or coacervates of protein/polysaccharide generated by electrostatic interactions to stabilize Pickering emulsions have attracted increasing… Continue reading Impact of pH on the interaction between soybean protein isolate and oxidized bacterial cellulose at oil-water interface: Dilatational rheological and emulsifying properties

pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature

2021 / Scientific Report

Peroxiredoxin 6 (Prdx6), the ubiquitously expressed enzyme belonging to the family of peroxidases, namely, peroxiredoxins, exhibits a unique feature of… Continue reading pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature

Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

2021 / Nature Communications

Furanosteroids, represented by wortmannin, viridin, and demethoxyviridin, are a special group of fungal-derived, highly oxygenated steroids featured by an extra… Continue reading Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors

2021 / Scientific Report

The maturation of coronavirus SARS-CoV-2, which is the etiological agent at the origin of the COVID-19 pandemic, requires a main… Continue reading The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors

A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system

2021 / Scientific Report

A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer… Continue reading A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system

C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition

2021 / Scientific Report

The c subunit is an inner mitochondrial membrane (IMM) protein encoded by three nuclear genes. Best known as an integral… Continue reading C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition

Characterization of a Bowman–Birk type trypsin inhibitor purified from seeds of Solanum surattense

2021 / Scientific Report

A Bowman–Birk type trypsin inhibitor protein (SSTI) from seeds of the medicinal plant Solanum surattense was isolated, purified and characterized.… Continue reading Characterization of a Bowman–Birk type trypsin inhibitor purified from seeds of Solanum surattense

A collagen glucosyltransferase drives lung adenocarcinoma progression in mice

2021 / Communication Biology

Cancer cells are a major source of enzymes that modify collagen to create a stiff, fibrotic tumor stroma. High collagen… Continue reading A collagen glucosyltransferase drives lung adenocarcinoma progression in mice

Secondary structural choice of DNA and RNA associated with CGG/CCG trinucleotide repeat expansion rationalizes the RNA misprocessing in FXTAS

2021 / Scientific Report

CGG tandem repeat expansion in the 5′-untranslated region of the fragile X mental retardation-1 (FMR1) gene leads to unusual nucleic… Continue reading Secondary structural choice of DNA and RNA associated with CGG/CCG trinucleotide repeat expansion rationalizes the RNA misprocessing in FXTAS

Chiral Silica with Preferred-Handed Helical Structure via Chiral Transfer

2021 / ACS Publications JACS Au 2021

A strategy to obtain chiral silica using an achiral stereoregular polymer with polyhedral oligomeric silsesquioxane (POSS) side chains is described… Continue reading Chiral Silica with Preferred-Handed Helical Structure via Chiral Transfer

Circular dichroism and resonance Raman spectroscopies of bacteriochlorophyll b-containing LH1-RC complexes

2021 / Photosynthesis Research (2021)

The core light-harvesting complexes (LH1) in bacteriochlorophyll (BChl) b-containing purple phototrophic bacteria are characterized by a near-infrared absorption maximum around… Continue reading Circular dichroism and resonance Raman spectroscopies of bacteriochlorophyll b-containing LH1-RC complexes

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

2021 / Nature Communications

TRPV4 is a cell surface-expressed calcium-permeable cation channel that mediates cell-specific effects on cellular morphology and function. Dominant missense mutations… Continue reading Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

Two New Phomaligols from the Marine-Derived Fungus Aspergillus flocculosus and Their Anti-Neuroinflammatory Activity in BV-2 Microglial Cells

2021 / MDPI

Two new phomaligols, deketo-phomaligol A (1) and phomaligol E (2), together with six known compounds (3–8) were isolated from the… Continue reading Two New Phomaligols from the Marine-Derived Fungus Aspergillus flocculosus and Their Anti-Neuroinflammatory Activity in BV-2 Microglial Cells

Design of buried charged networks in artificial proteins

2021 / Nature Communications

Soluble proteins are universally packed with a hydrophobic core and a polar surface that drive the protein folding process. Yet… Continue reading Design of buried charged networks in artificial proteins

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

2021 / Nature Communications

The self-assembly of α-synuclein (αS) into intraneuronal inclusion bodies is a key characteristic of Parkinson’s disease. To define the nature… Continue reading The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

Xianli Zhang

2021 / Food chemistry

This study aims to evaluate the effect of ultrasonic pretreatment combined with glycation on the structural characteristics and antibacterial activity… Continue reading Xianli Zhang

Synthesis and Structure-Chirality Relationship Analysis of Steroidal Quinoxalines to Design and Develop New Chiral Drugs

2021 / MDPI

Of the utmost importance of chirality in organic compounds and drugs, the present work reports structure-chirality relationship of three steroidal… Continue reading Synthesis and Structure-Chirality Relationship Analysis of Steroidal Quinoxalines to Design and Develop New Chiral Drugs

Conformational characterization of a novel anti-HER2 candidate antibody

2019 / PLOS ONE

Regulatory agencies establish that a broad physicochemical and biological characterization is necessary for the evaluation of comparability between a biosimilar… Continue reading Conformational characterization of a novel anti-HER2 candidate antibody

Stability Studies of the Vaccine Adjuvant U-Omp19

2020 / Journal of Pharmaceutical Sciences, RESEARCH ARTICLE DRUG DISCOVERY-DEVELOPMENT INTERFACE| VOLUME 110, ISSUE 2, P707-718, FEBRUARY 01, 2021

Unlipidated outer membrane protein 19 (U-Omp19) is a novel mucosal adjuvant in preclinical development to be used in vaccine formulations.… Continue reading Stability Studies of the Vaccine Adjuvant U-Omp19

Protein Sub-Visible Particle and Free Radical formation of a Freeze-Dried Monoclonal Antibody Formulation During Dropping

2020 / Journal of Pharmaceutical Sciences

Dropping during shipping and handling of liquid biopharmaceutical formulations has long been known to cause protein degradation and aggregation. On… Continue reading Protein Sub-Visible Particle and Free Radical formation of a Freeze-Dried Monoclonal Antibody Formulation During Dropping

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Impact of pH on the interaction between soybean protein isolate and oxidized bacterial cellulose at oil-water interface: Dilatational rheological and emulsifying properties

pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature

Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors

A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system

C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition

Characterization of a Bowman–Birk type trypsin inhibitor purified from seeds of Solanum surattense

A collagen glucosyltransferase drives lung adenocarcinoma progression in mice

Secondary structural choice of DNA and RNA associated with CGG/CCG trinucleotide repeat expansion rationalizes the RNA misprocessing in FXTAS

Chiral Silica with Preferred-Handed Helical Structure via Chiral Transfer

Circular dichroism and resonance Raman spectroscopies of bacteriochlorophyll b-containing LH1-RC complexes

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

Two New Phomaligols from the Marine-Derived Fungus Aspergillus flocculosus and Their Anti-Neuroinflammatory Activity in BV-2 Microglial Cells

Design of buried charged networks in artificial proteins

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

Xianli Zhang

Synthesis and Structure-Chirality Relationship Analysis of Steroidal Quinoxalines to Design and Develop New Chiral Drugs

Conformational characterization of a novel anti-HER2 candidate antibody

Stability Studies of the Vaccine Adjuvant U-Omp19

Protein Sub-Visible Particle and Free Radical formation of a Freeze-Dried Monoclonal Antibody Formulation During Dropping

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