Using high-resolution NMR spectroscopy we conducted a comparative analysis of the structural and dynamic properties of the bacteriophage T5 endolysin… Continue reading Structure and dynamics of the retro-form of the bacteriophage T5 endolysin
Leah Pandiscia, PhD
July 28, 2017
Binding characteristics of a promising anticancer drug, axitinib (AXT) to human serum albumin (HSA), the major transport protein in human… Continue reading Binding of an anticancer drug, axitinib to human serum albumin: Fluorescence quenching and molecular docking study
Leah Pandiscia, PhD
July 28, 2017
In this study, the interaction between the flavonoid pelargonidin and dairy proteins: β-lactoglobulin (β-LG), whey protein (WPI), and caseinate (CAS)… Continue reading Characterization of flavonoid-protein interactions using fluorescence spectroscopy: Binding of pelargonidin to dairy proteins
Leah Pandiscia, PhD
July 28, 2017
Dicationic (gemini) surfactants are agents that can be used for the preparation of stable complexes of nucleic acids, particularly siRNA… Continue reading Structural studies of the formation of lipoplexes between siRNA and selected bis-imidazolium gemini surfactants
Leah Pandiscia, PhD
July 28, 2017
The activating role of different polymer thin films coated over polystyrene support on theSynechococcus sp. biofilm growth was examined concurrently by… Continue reading Thin films of silk-fibroin and its blend with chitosan strongly promote biofilm growth of Synechococcus sp. BDU 140432
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Carbonic anhydrase VA (CAVA) is a mitochondrial enzyme belonging to the α-family of CAs, which is involved in several physiological… Continue reading GdnHCl-induced unfolding intermediate in mitochondrial carbonic anhydrase VA
Leah Pandiscia, PhD
July 28, 2017
Tyrosine sulfation is a post-translational modification that facilitates protein-protein interaction. Two sulfated tyrosines (Tys173 and Tys177) were recently identified within… Continue reading Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry
Leah Pandiscia, PhD
July 28, 2017
The mce4A gene of Mycobacterium tuberculosis encodes a 400 amino acid residues protein of 43 kDa, which is a mammalian cell entry protein (Mce4A) and… Continue reading Purification and Structural Characterization of Mce4A from Mycobacterium tuberculosis
Leah Pandiscia, PhD
July 28, 2017
While interferon alpha (IFNα) is used in several viral and cancer contexts, its efficacy against ovarian cancer (OC) is far… Continue reading A site-selective hyaluronan-interferonα2a conjugate for the treatment of ovarian cancer
Leah Pandiscia, PhD
July 28, 2017
The tumor suppressor protein p53 is a key factor in genome stability and one of the most studied of DNA… Continue reading p53 binds human telomeric G-quadruplex in vitro
Leah Pandiscia, PhD
July 28, 2017
Using synchrotron radiation-based circular dichroism spectroscopy, we found that the DNA damage response induces an increase of α-helix structure and a… Continue reading Structure Change from β-Strand and Turn to α-Helix in Histone H2A-H2B Induced by DNA Damage Response
Leah Pandiscia, PhD
July 28, 2017
The preparation and structural organisation of new bioinspired nanomaterials based on regular alternating enantiomeric sequence of tetra- and hexapeptides end-linked… Continue reading Self-assembly and drug release study of linear l,d-oligopeptide-poly(ethylene glycol) conjugates
Leah Pandiscia, PhD
July 28, 2017
The endosomal sorting complex required for transport (ESCRT) is a conserved protein complex that facilitates budding and fission of membranes.… Continue reading Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein
Leah Pandiscia, PhD
July 28, 2017
In situ encapsulation is a frequently used method to prepare hydrogels loaded with high quantities of therapeutic proteins. However, many… Continue reading Polyanions effectively prevent protein conjugation and activity loss during hydrogel cross-linking
Leah Pandiscia, PhD
July 28, 2017
Plasmodium reichenowi, an ape malaria parasite is morphologically identical and genetically similar to Plasmodium falciparum, infects chimpanzees but not humans.… Continue reading Baculovirus-expressed Plasmodium reichenowi EBA-140 merozoite ligand is host specific
Leah Pandiscia, PhD
July 28, 2017
In our continuing search for bioactive constituents from Korean medicinal sources, an investigation of the Sinomenium acutum Rehder et Wilson rhizome afforded… Continue reading Anti-neuroinflammatory constituents from Sinomenium acutum rhizomes
Leah Pandiscia, PhD
July 28, 2017
Ionotropic gelation of chitosan by means of opposite charged ions represents an efficient alternative to covalent reticulation because of milder… Continue reading Insight into the Ionotropic Gelation of Chitosan using Tripolyphosphate and Pyrophosphate as cross-linkers
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017