Green synthesis of anticancerous honeycomb PtNPs clusters: Their alteration effect on BSA and HsDNA using fluorescence probe

2016 / Journal of Photochemistry and Photobiology B: Biology

The screening and characterization of cancer cells has been challenging due to sample insufficiency and extravagant. In this article, we… Continue reading Green synthesis of anticancerous honeycomb PtNPs clusters: Their alteration effect on BSA and HsDNA using fluorescence probe

Leah Pandiscia, PhD

cAMP‐dependent protein kinase (PKA) complexes probed by complementary Differential Scanning Fluorimetry and Ion Mobility‐Mass Spectrometry

2016 / Biochemical Journal

cAMP‐dependent protein kinase (PKA) is an archetypal biological signaling module and a model for understanding the regulation of protein kinases.… Continue reading cAMP‐dependent protein kinase (PKA) complexes probed by complementary Differential Scanning Fluorimetry and Ion Mobility‐Mass Spectrometry

Leah Pandiscia, PhD

Interaction of lafutidine in binding to human serum albumin in gastric ulcer therapy: STD-NMR, WaterLOGSY-NMR, NMR relaxation times, Tr-NOESY, molecule docking, and spectroscopic studies

2016 / Archives of Biochemistry and Biophysics

In this study, lafutidine (LAF) was used as a model compound to investigate the binding mechanism between antiulcer drugs and… Continue reading Interaction of lafutidine in binding to human serum albumin in gastric ulcer therapy: STD-NMR, WaterLOGSY-NMR, NMR relaxation times, Tr-NOESY, molecule docking, and spectroscopic studies

Leah Pandiscia, PhD

Reversible NaCl-Induced Aggregation of a Monoclonal Antibody at low pH: Characterization of Aggregates and Factors Affecting Aggregation

2016 / European Journal of Pharmaceutics and Biopharmaceutics

We investigated the influence of pH and sodium choride concentration on aggregation kinetics of a monoclonal antibody. Aggregation was induced… Continue reading Reversible NaCl-Induced Aggregation of a Monoclonal Antibody at low pH: Characterization of Aggregates and Factors Affecting Aggregation

Leah Pandiscia, PhD

Coixlachryside A: A new lignan glycoside from the roots of Coix lachryma-jobi L. var. ma-yuen Stapf.

2016 / Phytochemistry Letters

A new lignan glycoside, 1-[3,6-(4,4′-dihydroxy-3,3′-dimethoxy-δ-truxinyl)-β-fructofuranosyl]-α-glucopyranoside (1), named coixlachryside A, together with nine known simple phenolic compounds (3–11) were isolated from… Continue reading Coixlachryside A: A new lignan glycoside from the roots of Coix lachryma-jobi L. var. ma-yuen Stapf.

Leah Pandiscia, PhD

Predicting unfolding thermodynamics and stable intermediates for alanine-rich helical peptides with the aid of coarse-grained molecular simulation

2016 / Biophysical Chemistry

This report focuses on the molecular-level processes and thermodynamics of unfolding of a series of helical peptides using a coarse-grained… Continue reading Predicting unfolding thermodynamics and stable intermediates for alanine-rich helical peptides with the aid of coarse-grained molecular simulation

Leah Pandiscia, PhD

A functional comparison of cardiac troponin C from representatives of three vertebrate taxa: Linking phylogeny and protein function

2016 / Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

The Ca2 + affinity of cardiac troponin C (cTnC) from rainbow trout is significantly greater than that of cTnC from mammalian species.… Continue reading A functional comparison of cardiac troponin C from representatives of three vertebrate taxa: Linking phylogeny and protein function

Leah Pandiscia, PhD

Novel phthalide derivatives from the rhizomes of Ligusticum chuanxiong and their inhibitory effect against lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells

2016 / RSC Advances

Five new phthalide derivatives, chuanxiongnolides L1–L5 (1–5), together with three known phthalide dimers (6–8), were isolated from the rhizomes of Ligusticum… Continue reading Novel phthalide derivatives from the rhizomes of Ligusticum chuanxiong and their inhibitory effect against lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells

Leah Pandiscia, PhD

A spectroscopic study on interaction between bovine serum albumin and titanium dioxide nanoparticle synthesized from microwave-assisted hybrid chemical approach

2016 / Journal of Photochemistry and Photobiology B: Biology

The use of nanoparticles in food or pharma requires a molecular-level perceptive of how NPs interact with protein corona once… Continue reading A spectroscopic study on interaction between bovine serum albumin and titanium dioxide nanoparticle synthesized from microwave-assisted hybrid chemical approach

Leah Pandiscia, PhD

Controlled DNA interpolyelectrolyte complex formation or dissociation via stimuli-responsive poly(vinylamine-co-N-vinylisobutylamide)

2016 / Journal of Applied Polymer Science

Poly(vinylamine-co-N-vinylisobutylamide) or poly(VAm-co-NVIBA) was evaluated for its ability to stabilize double-stranded DNA (dsDNA) with the controlled formation or dissociation of… Continue reading Controlled DNA interpolyelectrolyte complex formation or dissociation via stimuli-responsive poly(vinylamine-co-N-vinylisobutylamide)

Leah Pandiscia, PhD