Cobalt(III) complexes as potential anticancer agents: Physicochemical, structural, cytotoxic activity and DNA/protein interactions

2016 / Journal of Photochemistry and Photobiology B: Biology

Cobalt(III) complexes (1–3) such as [Co(acac)(bpy)(N3)2·H2O] 1, [Co(acac)(en)(N3)2] 2, and [Co(acac)(2-pic)(N3)2] 3 (where, acac = acetylacetone, bpy = 2.2′-bipyridine, en = ethylenediamine, 2-pic = 2-picolylamine and NaN3 = sodium azide) were synthesized and characterized.… Continue reading Cobalt(III) complexes as potential anticancer agents: Physicochemical, structural, cytotoxic activity and DNA/protein interactions

Leah Pandiscia, PhD

Self-assembling peptide for co-delivery of HIV-1 CD8+ T cells epitope and Toll-like receptor 7/8 agonists R848 to induce maturation of monocyte derived dendritic cell and augment polyfunctional cytotoxic T lymphocyte (CTL) response

2016 / Journal of Controlled Release

Peptide based vaccine that incorporates one or several highly conserved CD8+ T cells epitopes to induce potent cytotoxic T lymphocyte… Continue reading Self-assembling peptide for co-delivery of HIV-1 CD8+ T cells epitope and Toll-like receptor 7/8 agonists R848 to induce maturation of monocyte derived dendritic cell and augment polyfunctional cytotoxic T lymphocyte (CTL) response

Leah Pandiscia, PhD

Ultrastructural analysis of the decellularized cornea after interlamellar keratoplasty and microkeratome-assisted anterior lamellar keratoplasty in a rabbit model

2016 / Scientific Reports

The decellularized cornea has received considerable attention for use as an artificial cornea. The decellularized cornea is free from cellular… Continue reading Ultrastructural analysis of the decellularized cornea after interlamellar keratoplasty and microkeratome-assisted anterior lamellar keratoplasty in a rabbit model

Leah Pandiscia, PhD

Prussian blue/serum albumin/indocyanine green as a multifunctional nanotheranostic agent for bimodal imaging guided laser mediated combinatorial phototherapy

2016 / Journal of Controlled Release

Developing novel nanotheranostic agent using only clinically approved materials is highly desirable and challenging. In this study, we combined three… Continue reading Prussian blue/serum albumin/indocyanine green as a multifunctional nanotheranostic agent for bimodal imaging guided laser mediated combinatorial phototherapy

Leah Pandiscia, PhD

Peptide-poly(tert-butyl methacrylate) conjugate into composite micelles in organic solvents versuspeptide-poly(methacrylic acid) conjugate into spherical and worm-like micelles in water: Synthesis and self-assembly

2016 / Journal of Polymer Science Part A: Polymer Chemistry

Peptide–polymer conjugates are versatile class of biomaterials composed of a peptide block covalently linked with a synthetic polymer block. This… Continue reading Peptide-poly(tert-butyl methacrylate) conjugate into composite micelles in organic solvents versuspeptide-poly(methacrylic acid) conjugate into spherical and worm-like micelles in water: Synthesis and self-assembly

Leah Pandiscia, PhD

Engineering the thermostability of β-glucuronidase from Penicillium purpurogenum Li-3 by loop transplant

2016 / Applied Microbiology and Biotechnology

In this study, we proposed a loop transplant strategy to improve the thermostability of Penicillium purpurogenum Li-3 β-glucuronidase expressed in Escherichia coli (abbreviated to… Continue reading Engineering the thermostability of β-glucuronidase from Penicillium purpurogenum Li-3 by loop transplant

Leah Pandiscia, PhD