2021 / Nature Communications
α-Synuclein (αS) is a presynaptic disordered protein whose aberrant aggregation is associated with Parkinson’s disease. The functional role of αS… Continue reading The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition
2021 / Bioscience, Biotechnology, and Biochemistry
Cytochrome c’ is a nitric oxide (NO)-binding heme protein found in Gram negative bacteria. The thermal stability of psychrophilic Shewanella… Continue reading Thermal destabilization mechanism of cytochrome c’ from psychrophilic Shewanella violacea
2021 / Science Direct
The utilizations of the complexes or coacervates of protein/polysaccharide generated by electrostatic interactions to stabilize Pickering emulsions have attracted increasing… Continue reading Xingzhong Zhang
2021 / Nature Communications
Xylanolytic enzymes from glycoside hydrolase family 43 (GH43) are involved in the breakdown of hemicellulose, the second most abundant carbohydrate… Continue reading Two distinct catalytic pathways for GH43 xylanolytic enzymes unveiled by X-ray and QM/MM simulations
2021 / Nature Communications
The endoplasmic reticulum (ER) network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs.… Continue reading Mechanism of membrane-curvature generation by ER-tubule shaping proteins
2021 / Nature Communications
Some Bacteroidetes and other human colonic bacteria can degrade arabinoxylans, common polysaccharides found in dietary fiber. Previous work has identified… Continue reading Degradation of complex arabinoxylans by human colonic Bacteroidetes
2021 / Nature Communications
The exquisite structure-function correlations observed in filamentous protein assemblies provide a paradigm for the design of synthetic peptide-based nanomaterials. However,… Continue reading Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials
2021 / Nature Communications
Glycosidases are phylogenetically widely distributed enzymes that are crucial for the cleavage of glycosidic bonds. Here, we present the exceptional… Continue reading Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase
2021 / Scientific Reports
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a major health threat listed among the top 10 causes of death worldwide.… Continue reading Mycobacterium tuberculosis Rv3160c is a TetR-like transcriptional repressor that regulates expression of the putative oxygenase Rv3161c
2021 / Nature Communications
During autophagy the enzyme Atg3 catalyzes the covalent conjugation of LC3 to the amino group of phosphatidylethanolamine (PE) lipids, which… Continue reading An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy
2021 / Scientific Reports
Envelope glycoproteins from genetically-divergent virus families comprise fusion peptides (FPs) that have been posited to insert and perturb the membranes… Continue reading Conformational plasticity underlies membrane fusion induced by an HIV sequence juxtaposed to the lipid envelope
2021 / Bioscience, Biotechnology, and Biochemistry
Corydalis ambigua (Japanese name, Ezoengosaku) flowers bloom with blue to purplish petals in early spring in Hokkaido prefecture. In this… Continue reading Blue flower coloration of Corydalis ambigua requires ferric ion and kaempferol glycoside
2021 / Nature Communications
Despite great challenges, the development of new molecular structures with multiple and even conflicting characteristics are eagerly pursued for exploring… Continue reading π-Extended perylene diimide double-heterohelicenes as ambipolar organic semiconductors for broadband circularly polarized light detection
2020 / Nature Communications
Homo- and heterochiral aggregation during crystallization of organic molecules has significance both for fundamental questions related to the origin of… Continue reading Control of self-assembly pathways toward conglomerate and racemic supramolecular polymers
2020 / Nature Communications
Homo- and heterochiral aggregation during crystallization of organic molecules has significance both for fundamental questions related to the origin of… Continue reading Control of self-assembly pathways toward conglomerate and racemic supramolecular polymers
2020 / Scientific Reports
Structure, membrane topology and influence of cholesterol of the membrane proximal region: transmembrane helical anchor sequence of gp41 from HIV
2020 / npg Asia Materialsl
Mesoporous metal oxides consisting of fully interconnected network structures with small pores (20–50 nm) have high surface areas and decreased ion… Continue reading Extremely fast electrochromic supercapacitors based on mesoporous WO3 prepared by an evaporation-induced self-assembly
2020 / Scientific Reports
Chirality is an important consideration in drug development: it can influence recognition of the intended target, pharmacokinetics, and off-target effects.… Continue reading Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist
2020 / Computational and Structural Biotechnology
High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that triggers the progression of several pro-inflammatory… Continue reading The acidic tail of HMGB1 regulates its secondary structure and
conformational flexibility: A circular dichroism and molecular dynamics
simulation study
2020 / Scientific Reports
We have used NMR and circular dichroism spectroscopy to investigate the structural and dynamic effects of oxidation on calmodulin (CaM),… Continue reading Met125 is essential for maintaining the structural integrity of calmodulin’s C-terminal domain
