2008 / The Journal of Biological Chemistry
The hantaviruses are emerging infectious viruses that in humans can cause a cardiopulmonary syndrome or a hemorrhagic fever with renal… Continue reading NMR Structure of the N-terminal Coiled Coil Domain of the Andes Hantavirus Nucleocapsid Protein
2004 / Nucleic Acids Research
The anticancer antibiotic chromomycin A3 (Chro) is a DNA minor groove binding drug belonging to the aureolic family. Chro likely exerts… Continue reading Crystal structure of the [Mg2+‐(chromomycin A3)2]–d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion
2000 / Tetrahedron
Four novel cerebrosides, termitomycesphins A–D, were isolated from the edible Chinese mushroom Termitomyces albuminosus (Berk.) Heim. (‘Jizong’ in Chinese), shown to induce… Continue reading Termitomycesphins A–D, Novel Neuritogenic Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus
2000 / Journal of Biotechnology
The secondary structure and the thermostability of bovine serum albumin (BSA), before adsorption and after homomolecular displacement from silica and… Continue reading BSA structural changes during homomolecular exchange between the adsorbed and the dissolved states
2008 / Nature Chemical Biology
Hybrid multienzyme systems composed of polyketide synthase (PKS) and nonribosomal polypeptide synthetase (NRPS) modules direct the biosynthesis of clinically valuable… Continue reading Multienzyme docking in hybrid megasynthetases
2003 / Helvetica Chimica Acta
β-Peptides offer the unique possibility to incorporate additional heteroatoms into the peptidic backbone (Figs. 1 and 2). We report here the synthesis and… Continue reading Synthesis, CD Spectra, and Enzymatic Stability of β2-Oligoazapeptides Prepared from (S)-2-Hydrazino Carboxylic Acids Carrying the Side Chains of Val, Ala, and Leu
2004 / Nature Biotechnology
We describe a method for selecting aggregation-resistant proteins by heat denaturation. This is illustrated with antibody heavy chain variable domains… Continue reading Aggregation-resistant domain antibodies selected on phage by heat denaturation
2008 / RNA Biology
In order to relate the conformational dynamics of the hammerhead ribozyme to its biological function the cleavage reaction catalysed by… Continue reading NMR-spectroscopic characterisation of phosphodiester bond cleavage catalyzed by the minimal hammerhead ribozyme
2009 / Biochemical and Biophysical Research Communications
Prion diseases are associated with the misfolding of the host-encoded cellular prion protein (PrPC) into a disease associated form (PrPSc).… Continue reading Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence
2010 / Protein Science
The lethal genetic disease cystic fibrosis is caused predominantly by in-frame deletion of phenylalanine 508 in the cystic fibrosis transmembrane… Continue reading Integrated biophysical studies implicate partial unfolding of NBD1 of CFTR in the molecular pathogenesis of F508del cystic fibrosis
2007 / Chirality
Circular dichroism (CD) spectroscopy is widely used to characterize the structures of DNA G-quadruplexes. CD bands at 200–300 nm have… Continue reading Measured and calculated CD spectra of G-quartets stacked with the same or opposite polarities
2002 / Chemistry A European Journal
There are numerous possible γ-amino acids with different degrees of substitution and with various constitutions and configurations. Of these the γ4- and… Continue reading γ2-, γ3-, and γ2,3,4-Amino Acids, Coupling to γ-Hexapeptides: CD Spectra, NMR Solution and X-ray Crystal Structures of γ-Peptides
2007 / Journal of Biotechnology
l-Arginine (Arg) is a widely used additive for suppressing protein aggregation during refolding. Systematic screening of Arg analogs provides superior… Continue reading l-Argininamide improves the refolding more effectively than l-arginine
2005 / Advanced Materials
Although amphiphilic TARC18 is achiral, it can form chiral Langmuir–Schaefer (LS) films upon organization of the molecules at the air/water… Continue reading A Supramolecular Chiroptical Switch Exclusively from an Achiral Amphiphile
2000 / The Journal of Biological Chemistry
Mesophilic cytochrome c551 of Pseudomonas aeruginosa (PA c551) became as stable as its thermophilic counterpart, Hydrogenobacter thermophilus cytochrome c552 (HT… Continue reading Selected Mutations in a Mesophilic Cytochrome cConfer the Stability of a Thermophilic Counterpart
2005 / FEBS Letters
The small molecule coralyne was found to bind preferentially and strongly to single-stranded poly(A) with an apparent association constant (K a)… Continue reading Molecular recognition of nucleic acids: Coralyne binds strongly to poly(A)
2001 / Chemical and Pharmaceutical Bulletin
Eight phenolic compounds including two new lignan glucopyranosides together with a known alkaloid were isolated from the stems of Cynomorium… Continue reading Studies on a Medicinal Parasitic Plant: Lignans from the Stems of Cynomorium songaricum
2006 / Peptides
We have previously reported the copper binding properties of R3 peptide (residues 318–335: VTSKCGSLGNIHHKPGGG, according to the longest tau protein) derived from the… Continue reading Copper binding properties of a tau peptide associated with Alzheimer’s disease studied by CD, NMR, and MALDI-TOF MS
2001 / JACS
A general microscale protocol for the determination of absolute configurations of primary amino groups or secondary hydroxyl groups linked to… Continue reading Chiral Recognition by CD-Sensitive Dimeric Zinc Porphyrin Host. 1. Chiroptical Protocol for Absolute Configurational Assignments of Monoalcohols and Primary Monoamines
2011 / Biological Psychiatry
Both disrupted-in-schizophrenia 1 (DISC1) and dysbindin have been identified as schizophrenia candidate genes in independent genetic linkage studies. The proteins… Continue reading Convergence of Two Independent Mental Disease Genes on the Protein Level: Recruitment of Dysbindin to Cell-Invasive Disrupted-In-Schizophrenia 1 Aggresomes
