2020 / Scientific Reports
G protein-coupled receptors (GPCRs) are vital for diverse biological functions, including vision, smell, and aging. They are involved in a… Continue reading The G protein coupled receptor CXCR4 designed by the QTY code becomes more hydrophilic and retains cell signaling activity
2020 / Scientific Reports
Structural disorder represents a key feature in the mechanism of action of RNA-binding proteins (RBPs). Recent insights revealed that intrinsically… Continue reading A combined NMR and EPR investigation on the effect of the disordered RGG regions in the structure and the activity of the RRM domain of FUS
2020 / Scientific Reports
The yeast Pichia pastoris is a cost-effective and easily scalable system for recombinant protein production. In this work we compared… Continue reading Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells
2020 / Communication biology
Aggregation of human wild-type transthyretin (hTTR), a homo-tetrameric plasma protein, leads to acquired senile systemic amyloidosis (SSA), recently recognised as… Continue reading A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment
2020 / Nature Communications
Chiral metal complexes show promise as asymmetric catalysts and optical materials. Chiral-at-metal complexes composed of achiral ligands have expanded the… Continue reading Asymmetric construction of tetrahedral chiral zinc with high configurational stability and catalytic activity
2020 / Communications biology
Dynamic interactions of proteins with lipid membranes are essential regulatory events in biology, but remain rudimentarily understood and particularly overlooked… Continue reading The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity
2020 / Scientific Reports
Downhill folding has been defined as a unique thermodynamic process involving a conformations ensemble that progressively loses structure with the… Continue reading The change of conditions does not affect Ros87 downhill folding mechanism
2020 / Nature Communications
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease
2020 / J. Am. Chem. Soc. 2020
Strong enhancement of molecular circular dichroism (CD) has the potential to enable efficient asymmetric photolysis, a method of chiral separation… Continue reading Fluorescence-Detected Circular Dichroism of a Chiral Molecular Monolayer with Dielectric Metasurfaces
2020 / Scientific Reports volume 10, Article number: 14243 (2020)
The first described and best known mammalian secreted chaperone, abundant in human blood, is clusterin. Recent independent studies are now… Continue reading Rapid high-yield expression and purification of fully post-translationally modified recombinant clusterin and mutants
2020 / Nature Communications volume 11, Article number: 4513 (2020)
Chiral plasmonic nanoparticles can exhibit strong chiroptical signals compared to the corresponding molecular response. Observations are, however, generally restricted to… Continue reading Chiroptical spectroscopy of a freely diffusing single nanoparticle
2020 / Scientific Reports volume 10, Article number: 14430 (2020)
Based on the structure of an HIV-1 entry inhibitor peptide two stapled- and a retro-enantio peptides have been designed to… Continue reading Importance of structure-based studies for the design of a novel HIV-1 inhibitor peptide
2020 / Scientific Reports volume 10, Article number: 14845 (2020)
Small interfering RNAs (siRNAs) are potential tools for gene-silencing therapy, but their instability is one of the obstacles in the… Continue reading An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability
2020 / Nature Communications volume 11, Article number: 4562 (2020)
Symmetry breaking and amplification processes have likely played a fundamental role in the development of homochirality on earth. Such processes… Continue reading Amplification of enantiomeric excess by dynamic inversion of enantiomers in deracemization of Au38 clusters
2020 / Scientific Reports volume 10, Article number: 14657 (2020)
Cystathionine β-synthase (CBS) catalyzes the condensation of serine and homocysteine to water and cystathionine, which is then hydrolyzed to cysteine,… Continue reading Cystathionine β-synthase is involved in cysteine biosynthesis and H2S generation in Toxoplasma gondii
2020 / Nature Communications volume 11, Article number: 4169 (2020)
Sensing and responding to temperature is crucial in biology. The TRPV1 ion channel is a well-studied heat-sensing receptor that is… Continue reading Evidence that the TRPV1 S1-S4 membrane domain contributes to thermosensing
2020 / Scientific Reports volume 10, Article number: 14243 (2020)
The first described and best known mammalian secreted chaperone, abundant in human blood, is clusterin. Recent independent studies are now… Continue reading Rapid high-yield expression and purification of fully post-translationally modified recombinant clusterin and mutants
2020 / ACS Omega 2020, 5, 8, 4293–4301 Publication Date:February 17, 2020
The eye lens is mainly composed of the highly ordered water-soluble (WS) proteins named crystallins. The aggregation and insolubilization of… Continue reading Application of Circular Dichroism and Fluorescence Spectroscopies To Assess Photostability of Water-Soluble Porcine Lens Proteins
2019 / Scientific Reports volume 9, Article number: 1607 (2019)
Non-specific lipid transfer proteins (nsLTPs) are characterized by an eight-cysteine motif backbone that is stabilized by four disulphide bonds. The… Continue reading Identification of non-specific Lipid Transfer Protein gene family members in Solanum lycopersicum and insights into the features of Sola l 3 protein
2019 / Scientific Reports volume 9, Article number: 1556 (2019)
Der p 2 is a major dust mite allergen and >80% of mite allergic individuals have specific IgE to this… Continue reading The major allergen Der p 2 is a cholesterol binding protein
