2016 / Journal of Biological Inorganic Chemistry
Membrane-bound matrix metalloproteinase 16 (MMP16/MT3-MMP) is considered a drug target due to its role(s) in disease processes such as cancer… Continue reading Biochemical and spectroscopic characterization of the catalytic domain of MMP16 (cdMMP16)
2016 / Scientific Reports
p63 is a close homologue of p53 and, together with p73, is grouped into the p53 family of transcription factors.… Continue reading Solution structure and binding specificity of the p63 DNA binding domain
2016 / RSC Advances
The increasing utilization of nanoparticles for biological applications necessitates the understanding of the interaction of these nanoparticles with biomolecules. Hence,… Continue reading A comprehensive investigation of the differential interaction of human serum albumin with gold nanoparticles based on the variation in morphology and surface functionalization
2016 / The Journal of Physical Chemistry B
Lipid membranes interact with biomolecules via non-covalent bonding interactions, wherein the physicochemical membrane properties are key factors in the recognition… Continue reading Effect of Stearylguanidinium-Modified POPC Vesicles on the Melting Behavior of tRNA Molecules
2016 / Fitoterapia
Phytochemical investigation of the stem of Urceola huaitingii resulted in the isolation of nine proanthocyanidins (1-9), including a new compound (9). Their… Continue reading Anticancer activities of proanthocyanidins from the plantUrceola huaitingii and their synergistic effects in combination with chemotherapeutics
2016 / Helvetica Chimica Acta
Baeckea frutescens is an aromatic shrub used for ornamentals and food flavor spices in the southern part of China. Two novel C-methylated… Continue reading Baeckeins J and K, Two Novel C-Methylated Biflavonoids from the Roots of Baeckea frutescens and Their Cytoprotective Activities
2016 / FEBS Letters
BLUF domains are flavin-based photoreceptors which receive the blue light signal and are involved in the sensory transduction. We report… Continue reading Molecular Determinant Modulates Thermal Recovery Kinetics and Structural Integrity of the Bacterial BLUF Photoreceptor
2016 / Scientific Reports
Protein misfolding and aggregation have been associated with several human diseases such as Alzheimer’s, Parkinson’s and familial amyloid polyneuropathy etc.… Continue reading Vitamin k3 inhibits protein aggregation: Implication in the treatment of amyloid diseases
2016 / Organic and Biomolecular Chemistry
We developed a membrane-lytic peptide (LP) having 26 amino acid residues composed of a helix-promoting hydrophobic segment (Leu-Ala repetitive sequence)… Continue reading pH-Dependent Membrane Lysis by Melittin-Inspired Designed Peptides
2016 / Bioorganic and Medicinal Chemistry
A small peptide-keyhole limpet hemocyanin (KLH) conjugate is generally used as an antigen for producing specific antibodies. However, preparation of… Continue reading A sulfanyl-PEG derivative of relaxin-like peptide utilizable for the conjugation with KLH and the antibody production
2016 / Food Hydrocolloids
Low stability at high salt concentrations, iso-electric point, and high temperature restricted the application of proteins as stabilizers in nutraceutical… Continue reading Glycosylated α-lactalbumin-based nanocomplex for curcumin: Physicochemical stability and DPPH-scavenging activity
2016 / Journal of Photochemistry and Photobiology B: Biology
The interaction of the putative anticancer alkaloid chelerythrine with tRNAphe was characterized by spectroscopy, calorimetry and molecular docking studies. The charged… Continue reading Structural and thermodynamic analysis of the binding of tRNAphe by the putative anticancer alkaloid chelerythrine: Spectroscopy, calorimetry and molecular docking studies
2016 / Dalton Transactions
Recent work by several groups has established that MhuD, IsdG, and IsdI are non-canonical heme oxygenases that induce significant out-of-plane… Continue reading Dynamic Ruffling Distortion of the Heme Substrate in Non-Canonical Heme Oxygenase Enzymes
2016 / International Journal of Biological Macromolecules
Stem bromelain, a cysteine proteases from Ananas comosus is a widely accepted therapeutic drug with broad medicinal application. It exists as intermediate… Continue reading Amyloidogenic behavior of different intermediate state of stem bromelain; A Biophysical Insight
2016 / The Journal of Biological Chemistry
Metallo-β-lactamases catalyse the hydrolysis of most β-lactam antibiotics and hence represent a major clinical concern. The development of inhibitors for… Continue reading The role of active site flexible loops in catalysis and of zinc in conformational stability of Bacillus cereus 569/H/9 β-lactamase
2016 / Sustainable Chemistry and Pharmacy
The purpose of the study is isolation and application of novel Hot spring bacterial enzymes. It also reports on purification… Continue reading Thermostable amylase production from hot spring isolateExiguobacterium sp: A promising agent for natural detergents
2016 / Journal of Inorganic Biochemistry
Gold(I) based drugs are interesting for their potential medical use. The relatively facile ligand substitution in linear gold(I) compounds makes… Continue reading Effects of coordination mode of 2-mercaptothiazoline on reactivity of Au(I) compounds with thiols and sulfur-containing proteins
2016 / Bioorganic Chemistry
A new phosphorus(V) corrole, 10-(4-hydroxylphenyl)-5,15-bis(pentafluorophenyl)corrolato (trans-dihydroxo)phosphorus(V) 1-P, was synthesized and characterized. The interaction of 1-P and calf thymus DNA (CT-DNA) was studied… Continue reading Phosphorus(V) Corrole: DNA Binding, Photonuclease Activity and Cytotoxicity toward Tumor Cells
2016 / International Journal of Biological Macromolecules
Bacillus licheniformis γ-glutamyltranspeptidase (BlGGT) belongs to N-terminal nucleophile hydrolase superfamily in which all inclusive members are synthetized as single-chain precursors, and… Continue reading Site-directed mutagenesis of a conserved Asn450 residue ofBacillus licheniformis γ-glutamyltranspeptidase
2016 / Journal of Colloid and Interface Science
Exploring and understanding the fundamental interaction between protein and surfactant is utmost important for various pharmaceutical and biomedical applications. However,… Continue reading Insights into the morphology of human serum albumin and sodium dodecyl sulfate complex: A spectroscopic and microscopic approach
