2016 / Journal of Luminescence
A new series of brominated derivatives of 2, 3-dihydroquinazolin-4(1H)-one were synthesized and their structures were confirmed using IR, NMR and… Continue reading Study of binding interaction between anthelmintic 2, 3-dihydroquinazolin-4-ones with bovine serum albumin by spectroscopic methods
2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
The recovery of secondary structure in disordered, disulfide-reduced hen egg white lysozyme (HEWL) upon interaction with lipid vesicles was studied… Continue reading Reduced and mutant lysozyme refolding with lipid vesicles. Model study of disulfide impact on equilibria and dynamics
2016 / Protein Expression and Purification
The adenosine A2A receptor (A2AR) is a much-studied class A G protein-coupled receptor (GPCR). For biophysical studies, A2AR is commonly purified… Continue reading Impact of purification conditions and history on A2A adenosine receptor activity: The role of CHAPS and lipids
2016 / Biochimica et Biophysica Acta (BBA) - Biomembranes
Cell-penetrating peptides (CPPs) are short membrane-permeating amino acid sequences that can be used to deliver cargoes, e.g. drugs, into cells.… Continue reading SAP(E) – A Cell-Penetrating Polyproline Helix at Lipid Interfaces
2016 / Cell Reports
Transcription factors (TFs) play multiple roles in development. Given this multifunctionality, it has been assumed that TFs are evolutionarily highly… Continue reading A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1
2016 / Chemical Physics Letters
Horseradish peroxidase (HRP) is a classical heme-containing protein which has been applied in many fields. The prosthetic group heme in… Continue reading A fluorescence approach to the unfolding thermodynamics of horseradish peroxidase based on heme degradation by hydrogen peroxide
2016 / Chinese Chemical Letters
Two new N-methyladenine-containing diterpenes, nemoechines F (1) and G (2), were isolated from the South China Sea sponge Agelas aff. nemoechinata. The structures were… Continue reading Two new diterpene alkaloids from the South China Sea Sponge Agelas aff. nemoechinata
2016 / Journal of Biotechnology
Cytochromes P450 (P450s) require electron transfer partners to catalyze substrate conversions. With regard to biotechnological approaches, the elucidation of novel… Continue reading A Novel NADPH-dependent flavoprotein reductase fromBacillus megaterium acts as an efficient cytochrome P450 reductase
2016 / Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Brown spider phospholipases D from Loxosceles venoms are among the most widely studied toxins since they induce dermonecrosis, triggering inflammatory responses, increase… Continue reading Active site mapping of Loxosceles phospholipases D: Biochemical and biological features
2016 / Biophysical Journal
In the presence of K+ ions, the 5′-GGGTGGGTGGGTGGG-3′ (G3T) sequence folds into a monomolecular quadruplex with unusually high thermal stability and… Continue reading Stable Domain Assembly of a Monomolecular DNA Quadruplex: Implications for DNA-Based Nanoswitches
2016 / Food Chemistry
Lipid peroxidation can react with free amines of proteins and induce modification of structural and functional properties. This study presents… Continue reading Effect of 4-hydroxy-2-nonenal treatment on the IgE binding capacity and structure of shrimp (Metapenaeus ensis) tropomyosin
2016 / Materials Science and Engineering: C
Layer-by-Layer (LbL) films containing silk fibroin (SF) and the 40 aminoacid-long amyloid-β peptide (Aβ1-40) were prepared with the purpose of… Continue reading Immunosensor for diagnosis of Alzheimer disease using amyloid-β 1–40 peptide and silk fibroin thin films
2016 / Protein Expression and Purification
Centrins are acidic proteins, present in all eukaryotes to perform imperative roles in centrosome positioning and segregation. Existing methods for… Continue reading Optimization of purification method and characterization of recombinant human Centrin-1
2016 / Chinese Chemical Letters
Three new napelline-type C20-diterpenoid alkaloids, named aconicarmichinium A and B trifluoroacetates (1 and 2) and aconicarmichinium C chloride (3), were isolated from… Continue reading Napelline-type C20-diterpenoid alkaloid iminiums from an aqueous extract of “fu zi”: Solvent-/base-/acid-dependent transformation and equilibration between alcohol iminium and aza acetal forms
2016 / Physical Chemistry Chemical Physics
The LEA (late embryogenesis abundant) proteins COR15A and COR15B from Arabidopsis thaliana are intrinsically disordered under fully hydrated conditions, but obtain α-helical… Continue reading Molecular dynamics simulations and CD spectroscopy reveal hydration-induced unfolding of the intrinsically disordered LEA proteins COR15A and COR15B from Arabidopsis thaliana
2016 / Biochimica et Biophysica Acta (BBA) - Biomembranes
Further discovery and design of new anticancer peptides are important for the development of anticancer therapeutics, and study on the… Continue reading From a pro-apoptotic peptide to a lytic peptide: One single residue mutation
2016 / International Journal of Pharmaceutics
RNA interference provides a powerful technology for specific gene silencing. Therapeutic applications of small interfering RNA (siRNA) however require efficient… Continue reading Optimisation of vectorisation property: a comparative study for a secondary amphipathic peptide
2016 / Journal of Photochemistry and Photobiology B: Biology
RNA targeting through small molecules that can selectively bind specific RNA structures is an important current strategy in therapeutic drug… Continue reading Spectroscopic and calorimetric investigations on the binding of phenazinium dyes safranine-O and phenosafranine to double stranded RNA polynucleotides
2005 / Physical Chemistry Chemical Physics
A computational (ab initio and molecular dynamics) and experimental exploration of the relative importance of molecular conformation and explicit solvent effects on the… Continue reading Structure, electronic circular dichroism and Raman optical activity in the gas phase and in solution: a computational and experimental investigation
2008 / Biochemistry
The binding of divalent copper ions to the full-length recombinant murine prion protein PrP23-231at neutral pH was studied using vibrational… Continue reading Raman Optical Activity and Circular Dichroism Reveal Dramatic Differences in the Influence of Divalent Copper and Manganese Ions on Prion Protein Folding
