Circular Dichroism Archives

Transition of phosphopantetheine adenylyltransferase from catalytic to allosteric state is characterized by ternary complex formation in Pseudomonas aeruginosa

2016 / Biochimica et Biophysica Acta (BBA)- Proteins and Proteomics

Phosphopantetheine adenylyltransferase (PPAT) is a rate limiting enzyme which catalyzes the conversion of ATP and pantetheine to dephosphocoenzyme and pyrophosphate.… Continue reading Transition of phosphopantetheine adenylyltransferase from catalytic to allosteric state is characterized by ternary complex formation in Pseudomonas aeruginosa

Protein stability, conformational change and binding mechanism of human serum albumin upon binding of embelin and its role in disease control

2016 / Journal of Photochemistry and Photobiology B: Biology

Here, we present the inclusive binding mode of phytochemical embelin, an anticancer drug with human serum albumin (HSA) established under… Continue reading Protein stability, conformational change and binding mechanism of human serum albumin upon binding of embelin and its role in disease control

Long-lasting hypoglycemic effect of modified FGF-21 analog with polyethylene glycol in type 1 diabetic mice and its systematic toxicity

2016 / European Journal of Pharmacology

Fibroblast growth factor-21 (FGF-21) is a novel metabolic regulator and has the potential to become a powerful therapy to treat… Continue reading Long-lasting hypoglycemic effect of modified FGF-21 analog with polyethylene glycol in type 1 diabetic mice and its systematic toxicity

Conformational changes induced by high-pressure homogenization inhibit myosin filament formation in low ionic strength solutions

2016 / Food Research International

Myofibrillar proteins (MPs) of chicken breast are generally insoluble in water. We have developed a new method whereby MPs are… Continue reading Conformational changes induced by high-pressure homogenization inhibit myosin filament formation in low ionic strength solutions

Aptamer targeting of the elongation factor 1A impairs hepatocarcinoma cells viability and potentiates bortezomib and idarubicin effects

2016 / International Journal of Pharmaceutics

The high morbidity and mortality of hepatocellular carcinoma (HCC) is mostly due to the limited efficacy of the available therapeutic… Continue reading Aptamer targeting of the elongation factor 1A impairs hepatocarcinoma cells viability and potentiates bortezomib and idarubicin effects

Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima arginine binding protein

2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

The Arginine Binding Protein isolated from Thermotoga maritima (TmArgBP) is a protein endowed with several peculiar properties. We have previously shown that… Continue reading Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima arginine binding protein

Solvent-controlled Sign Inversion of Circularly Polarized Luminescent Binaphthylacetic Acid Derivative

2016 / Journal of Photochemistry and Photobiology A: Chemistry

For the selective emission of positive- and negative-sign circularly polarized luminescence (CPL), two chiral organic luminophores with opposing chirality are… Continue reading Solvent-controlled Sign Inversion of Circularly Polarized Luminescent Binaphthylacetic Acid Derivative

Structural Basis for the Functional Coupling of the Alternative Splicing Factors Smu1 and RED

2016 / Structure

The proteins Smu1 and RED have been jointly implicated in the regulation of alternative splicing, mitosis, and influenza virus infection,… Continue reading Structural Basis for the Functional Coupling of the Alternative Splicing Factors Smu1 and RED

Binding of ethyl pyruvate to bovine serum albumin: Calorimetric, spectroscopic and molecular docking studies

2016 / Thermochimica Acta

Various in vitro and in vivo studies have shown the anti-inflammatory and anticancer potential role of ethyl pyruvate. Bio-distribution of drugs is significantly influenced… Continue reading Binding of ethyl pyruvate to bovine serum albumin: Calorimetric, spectroscopic and molecular docking studies

Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells

2016 / Biochimie

A novel approach to cancer therapeutics is emerging in the field of G-quadruplex (G4) ligands, small molecules designed to stabilize… Continue reading Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells

DNA binding, BSA interaction and SOD activity of two new nickel(II) complexes with glutamine Schiff base ligands

2016 / Journal of Photochemistry and Photobiology B: Biology

Two hexacoordinated octahedral nickel(II) complexes, [Ni(o-van-gln)(phen)(H2O)](1) and [Ni(sal-gln)(phen)(H2O)](2) [o-van-gln = a Schiff base derived from o-vanillin and glutamine, sal-gln = a Schiff base derived from… Continue reading DNA binding, BSA interaction and SOD activity of two new nickel(II) complexes with glutamine Schiff base ligands

Characterization of the binding of an anticancer drug, lapatinib to human serum albumin

2016 / Journal of Photochemistry and Photobiology B: Biology

Interaction of a promising anticancer drug, lapatinib (LAP) with the major transport protein in human blood circulation, human serum albumin… Continue reading Characterization of the binding of an anticancer drug, lapatinib to human serum albumin

An extended loop in CE7 carbohydrate esterase family is dispensable for oligomerization but required for activity and thermostability

2016 / Journal of Structural Biology

The carbohydrate esterase family 7 (CE7) belonging to the α/β hydrolase superfamily contains a structurally conserved loop extension element relative… Continue reading An extended loop in CE7 carbohydrate esterase family is dispensable for oligomerization but required for activity and thermostability

Plasmonic Toroidal Metamolecules Assembled by DNA Origami

2016 / JACS

We show hierarchical assembly of plasmonic toroidal metamolecules that exhibit tailored optical activity in the visible spectral range. Each metamolecule… Continue reading Plasmonic Toroidal Metamolecules Assembled by DNA Origami

Formulation Studies During Preclinical Development of Influenza Hemagglutinin and Virus-Like Particle Vaccine Candidates

2016 / Vaccine Design

A critical element of vaccine formulation studies is the identification of chemical and physical degradation pathways that compromise structural integrity,… Continue reading Formulation Studies During Preclinical Development of Influenza Hemagglutinin and Virus-Like Particle Vaccine Candidates

How Soluble GARP Enhances TGFβ Activation

2016 / PLoS ONE

GARP (glycoprotein A repetitions predominant) is a cell surface receptor on regulatory T-lymphocytes, platelets, hepatic stellate cells and certain cancer… Continue reading How Soluble GARP Enhances TGFβ Activation

A comparative binding mechanism between human serum albumin and α-1-acid glycoprotein with corilagin: biophysical and computational approach

2016 / RSC Advances

The binding of corilagin with plasma serum proteins like human serum albumin (HSA) and α-1-acid glycoprotein (AGP) was investigated under… Continue reading A comparative binding mechanism between human serum albumin and α-1-acid glycoprotein with corilagin: biophysical and computational approach

Phenylboronic acid-based amphiphilic glycopolymeric nanocarriers for in vivo insulin delivery

2016 / Polymer Chemistry

Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting millions of people across the world. Oral delivery… Continue reading Phenylboronic acid-based amphiphilic glycopolymeric nanocarriers for in vivo insulin delivery

Peroxidase-like Catalytic Activity of Copper-Mediated Protein–Inorganic Hybrid Nanoflowers and Nanofibers of β-Lactoglobulin and α-Lactalbumin: Synthesis, Spectral Characterization, Microscopic Features, and Catalytic Activity

2016 / Applied Materials and Interfaces

A free Cys-SH-containing protein, β-lactoglobulin (β-LG), and another protein not possessing the same, viz., apo-α-lactoglobulin (apo-α-LA), were used in studies… Continue reading Peroxidase-like Catalytic Activity of Copper-Mediated Protein–Inorganic Hybrid Nanoflowers and Nanofibers of β-Lactoglobulin and α-Lactalbumin: Synthesis, Spectral Characterization, Microscopic Features, and Catalytic Activity

Structure analysis of a glycosides hydrolase family 42 cold-adapted β-galactosidase from Rahnella sp. R3

2016 / RSC Advances

The β-galactosidase isolated from a psychrotrophic bacterium, Rahnella sp. R3 (R-β-Gal), exhibits high activity at low temperature and has potential in the… Continue reading Structure analysis of a glycosides hydrolase family 42 cold-adapted β-galactosidase from Rahnella sp. R3

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Transition of phosphopantetheine adenylyltransferase from catalytic to allosteric state is characterized by ternary complex formation in Pseudomonas aeruginosa

Protein stability, conformational change and binding mechanism of human serum albumin upon binding of embelin and its role in disease control

Long-lasting hypoglycemic effect of modified FGF-21 analog with polyethylene glycol in type 1 diabetic mice and its systematic toxicity

Conformational changes induced by high-pressure homogenization inhibit myosin filament formation in low ionic strength solutions

Aptamer targeting of the elongation factor 1A impairs hepatocarcinoma cells viability and potentiates bortezomib and idarubicin effects

Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima arginine binding protein

Solvent-controlled Sign Inversion of Circularly Polarized Luminescent Binaphthylacetic Acid Derivative

Structural Basis for the Functional Coupling of the Alternative Splicing Factors Smu1 and RED

Binding of ethyl pyruvate to bovine serum albumin: Calorimetric, spectroscopic and molecular docking studies

Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells

DNA binding, BSA interaction and SOD activity of two new nickel(II) complexes with glutamine Schiff base ligands

Characterization of the binding of an anticancer drug, lapatinib to human serum albumin

An extended loop in CE7 carbohydrate esterase family is dispensable for oligomerization but required for activity and thermostability

Plasmonic Toroidal Metamolecules Assembled by DNA Origami

Formulation Studies During Preclinical Development of Influenza Hemagglutinin and Virus-Like Particle Vaccine Candidates

How Soluble GARP Enhances TGFβ Activation

A comparative binding mechanism between human serum albumin and α-1-acid glycoprotein with corilagin: biophysical and computational approach

Phenylboronic acid-based amphiphilic glycopolymeric nanocarriers for in vivo insulin delivery

Peroxidase-like Catalytic Activity of Copper-Mediated Protein–Inorganic Hybrid Nanoflowers and Nanofibers of β-Lactoglobulin and α-Lactalbumin: Synthesis, Spectral Characterization, Microscopic Features, and Catalytic Activity

Structure analysis of a glycosides hydrolase family 42 cold-adapted β-galactosidase from Rahnella sp. R3

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