• Year

  • Technique

  • Industry

Transition of phosphopantetheine adenylyltransferase from catalytic to allosteric state is characterized by ternary complex formation in Pseudomonas aeruginosa

2016 / Biochimica et Biophysica Acta (BBA)- Proteins and Proteomics

Phosphopantetheine adenylyltransferase (PPAT) is a rate limiting enzyme which catalyzes the conversion of ATP and pantetheine to dephosphocoenzyme and pyrophosphate.… Continue reading Transition of phosphopantetheine adenylyltransferase from catalytic to allosteric state is characterized by ternary complex formation in Pseudomonas aeruginosa

Leah Pandiscia, PhD July 28, 2017

Protein stability, conformational change and binding mechanism of human serum albumin upon binding of embelin and its role in disease control

2016 / Journal of Photochemistry and Photobiology B: Biology

Here, we present the inclusive binding mode of phytochemical embelin, an anticancer drug with human serum albumin (HSA) established under… Continue reading Protein stability, conformational change and binding mechanism of human serum albumin upon binding of embelin and its role in disease control

Leah Pandiscia, PhD July 28, 2017

Aptamer targeting of the elongation factor 1A impairs hepatocarcinoma cells viability and potentiates bortezomib and idarubicin effects

2016 / International Journal of Pharmaceutics

The high morbidity and mortality of hepatocellular carcinoma (HCC) is mostly due to the limited efficacy of the available therapeutic… Continue reading Aptamer targeting of the elongation factor 1A impairs hepatocarcinoma cells viability and potentiates bortezomib and idarubicin effects

Leah Pandiscia, PhD July 28, 2017

Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima arginine binding protein

2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

The Arginine Binding Protein isolated from Thermotoga maritima (TmArgBP) is a protein endowed with several peculiar properties. We have previously shown that… Continue reading Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima arginine binding protein

Leah Pandiscia, PhD July 28, 2017

DNA binding, BSA interaction and SOD activity of two new nickel(II) complexes with glutamine Schiff base ligands

2016 / Journal of Photochemistry and Photobiology B: Biology

Two hexacoordinated octahedral nickel(II) complexes, [Ni(o-van-gln)(phen)(H2O)](1) and [Ni(sal-gln)(phen)(H2O)](2) [o-van-gln = a Schiff base derived from o-vanillin and glutamine, sal-gln = a Schiff base derived from… Continue reading DNA binding, BSA interaction and SOD activity of two new nickel(II) complexes with glutamine Schiff base ligands

Leah Pandiscia, PhD July 28, 2017

An extended loop in CE7 carbohydrate esterase family is dispensable for oligomerization but required for activity and thermostability

2016 / Journal of Structural Biology

The carbohydrate esterase family 7 (CE7) belonging to the α/β hydrolase superfamily contains a structurally conserved loop extension element relative… Continue reading An extended loop in CE7 carbohydrate esterase family is dispensable for oligomerization but required for activity and thermostability

Leah Pandiscia, PhD July 28, 2017

Peroxidase-like Catalytic Activity of Copper-Mediated Protein–Inorganic Hybrid Nanoflowers and Nanofibers of β-Lactoglobulin and α-Lactalbumin: Synthesis, Spectral Characterization, Microscopic Features, and Catalytic Activity

2016 / Applied Materials and Interfaces

A free Cys-SH-containing protein, β-lactoglobulin (β-LG), and another protein not possessing the same, viz., apo-α-lactoglobulin (apo-α-LA), were used in studies… Continue reading Peroxidase-like Catalytic Activity of Copper-Mediated Protein–Inorganic Hybrid Nanoflowers and Nanofibers of β-Lactoglobulin and α-Lactalbumin: Synthesis, Spectral Characterization, Microscopic Features, and Catalytic Activity

Leah Pandiscia, PhD July 28, 2017