2016 / Biochemistry
RecA plays a central role in bacterial DNA repair, homologous recombination, and restoration of stalled replication forks by virtue of… Continue reading Molecular Mechanism Underlying ATP-Induced Conformational Changes in the Nucleoprotein Filament of Mycobacterium smegmatis RecA
2016 / Molecular Plant Pathology
Although the lifestyles and infection strategies of plant pathogens are diverse, a prevailing feature is the use of an arsenal… Continue reading Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studies
2016 / Open Journal of Polymer Chemistry
A series of polyaniline (PANI)/zinc oxide (ZnO) nano-particle (diameter 70 nm) composite films were prepared by electrochemical polymerization in the… Continue reading Preparation of Polyaniline/ZnO Films by Electrochemical Polymerization
2016 / Scientific Reports
Nucleoprotein (NP) is the most abundant type of RNA-binding viral protein in influenza A virus–infected cells and is necessary for… Continue reading Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development
2016 / Scientific Reports
Structural evolution from monomer to fibril of amyloid β peptide is related to pathogenic mechanism of Alzheimer disease, and its acceleration is… Continue reading Nucleus factory on cavitation bubble for amyloid β fibril
2016 / Scientific Reports
Due to the growing concern about antibiotic-resistant microbial infections, increasing support has been given to new drug discovery programs. A… Continue reading A polyalanine peptide derived from polar fish with anti-infectious activities
2016 / PLoS ONE
The candidacidal activity of histatin 5 is initiated through cell wall binding, followed by translocation and intracellular targeting, while the… Continue reading Antifungal Activity and Action Mechanism of Histatin 5-Halocidin Hybrid Peptides against Candida ssp
2016 / Journal of Biomolecular Structure and Dynamics
High-mobility group A1 (HMGA1) is a non-histone chromosomal protein, which is known as ‘architectural’ transcription factor that facilitates the assembly… Continue reading Triplex forming oligonucleotides targeted tohmga1 selectively inhibit its expression and induce apoptosis in human cervical cancer
2016 / Natural Product Research
One new indole alkaloid (1) and one new indole alkaloidal glycoside (2), together with nine known alkaloids (3–11), were isolated… Continue reading New alkaloids from the leaves of Evodia rutaecarpa
2016 / Amino Acids
Previous work demonstrated that Lys homopeptides with an odd number of residues (9, 11 and 13) were capable of inhibiting… Continue reading Inhibitory effect of short cationic homopeptides against Gram-negative bacteria
2016 / Molecules
Two new sesquiterpenoids, 3-oxo-7-hydroxylholosericin A (1) and 1,5;8,12-diepoxy-guaia-12-one (2), together with seven known sesquiterpenoids 3–9, were isolated from Chinese agarwood induced… Continue reading Sesquiterpenoids from Chinese Agarwood Induced by Artificial Holing
2016 / The FEBS Journal
Brain acid-soluble protein-1 (BASP1) and growth-associated protein-43 (GAP-43) are presynaptic membrane proteins participating in axon guidance, neuroregeneration and synaptic plasticity.… Continue reading High-order oligomers of intrinsically disordered brain proteins BASP1 and GAP-43 preserve the structural disorder
2016 / The Journal of Biological Chemistry
Peroxiredoxin 6 (Prdx6), a bifunctional protein with phospholipase A2 (aiPLA2) and GSH peroxidase activities, protects lungs from oxidative stress and participates… Continue reading Mutation of serine 32 to threonine in peroxiredoxin 6 preserves its structure and enzymatic function but abolishes its trafficking to lamellar bodies.
2016 / European Journal of Medicinal Chemistry
Four copper(II) complexes with chiral Schiff-base ligands, [Cu(R-L1)2]·EtOAc (1) and [Cu(S-L1)2]·EtOAc (2), [Cu(R-L2)2]·EtOAc (3) and [Cu(S-L2)2]·EtOAc (4), (R/S-HL1 = (R/S)-(1-naththyl)-salicylaldimine, R/S-HL2 = (R/S)-(1-naththyl)-3-methoxysalicylaldimine, EtOAc = ethyl acetate)… Continue reading Copper Complexes Based on Chiral Schiff-base Ligands: DNA/BSA Binding Ability, DNA Cleavage Activity, Cytotoxicity and Mechanism of Apoptosis
2016 / Amino Acids
We investigate the effect of the N-terminus modification of the L1A, a synthetic octadecapeptide, on its helical content, affinity and… Continue reading Effects of N‑terminus modifications on the conformation and permeation activities of the synthetic peptide L1A
2016 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Enzymatically-induced degradation of bovine serum albumin (BSA) by serine proteases (trypsin and α-chymotrypsin) in various concentrations was monitored by means… Continue reading Proteolytically-induced changes of secondary structural protein conformation of bovine serum albumin monitored by Fourier transform infrared (FT-IR) and UV-circular dichroism spectroscopy
2016 / Journal of Colloid and Interface Science
A detailed characterization of the binding interaction of a potent cancer cell photosensitizer, norharmane (NHM) with a genomic DNA (herring… Continue reading Interaction of an anti-cancer photosensitizer with a genomic DNA: From base pair specificity and thermodynamic landscape to tuning the rate of detergent-sequestered dissociation
2016 / Journal of Inorganic Biochemistry
The basic knowledge about biological inorganic chemistry, thermodynamics and metal binding sites of metalloproteins is crucial for the understanding of… Continue reading HENRYK — An endless source of metal coordination surprises
2016 / Biochemical and Biophysical Research Communications
TALipB (33 kDa) is a solvent stable, enantioselective lipase from Trichosporon asahiiMSR54. It is cysteine-rich and shows activation in presence of thiol… Continue reading Selective disruption of disulphide bonds lowered activation energy and improved catalytic efficiency in TALipB fromTrichosporon asahii MSR54: MD simulations revealed flexible lid and extended substrate binding area in the mutant
2016 / Colloids and Surfaces B: Biointerfaces
Refractive index matching was used to create optically transparent polyaphrons to enable proteins adsorbed to the aphron surface to be… Continue reading Refractive index matching to develop transparent polyaphrons: Characterization of immobilized proteins
