2016 / Molecular Pharmaceutics
Development of safe and effective gene carriers is the key to the success of gene therapy. Nowadays, it is still… Continue reading Cyclen Grafted with poly[(Aspartic acid)-co-Lysine]: Preparation, Assembly with Plasmid DNA, and in Vitro Transfection Studies
2016 / Inorganic Chemistry
Chelating phosphines are effective additives and supporting ligands for a wide array of iron-catalyzed cross-coupling reactions. While recent studies have… Continue reading Electronic Structure and Bonding in Iron(II) and Iron(I) Complexes Bearing Bisphosphine Ligands of Relevance to Iron-Catalyzed C−C Cross-Coupling
2016 / Inorganic Chemistry
Six new hybrid compounds based on [Co2Mo10H4O38]6– polyoxoanion, (4-H2pya)6Co2Mo10H4O38·10H2O 1 (4-Hpya =3-(4-pyridyl)acrylic acid) and (4-H2pya)4[M(H2O)6][Co2Mo10H4O38]·5H2O (M = Co 2, Ni 3, Cu 4, Zn 5, Cd 6), were… Continue reading Spontaneous Resolution of Evans−Showell-Type Polyoxometalates in Constructing Chiral Inorganic−Organic Hybrid Architectures
2016 / Biochemistry
Guanine-rich oligonucleotides can form a unique G-quadruplex (GQ) structure with stacking units of four guanine bases organized in a plane… Continue reading Conformations of Human Telomeric G‑Quadruplex Studied Using a Nucleotide-Independent Nitroxide Label
2016 / Journal Physical Chemistry Letters
We present experimental Raman optical activity (ROA) spectra of enantio-enriched single-walled carbon nanotubes (SWCNTs). Enantiomeric samples of (6,5) SWCNTs were… Continue reading Resonance Raman Optical Activity Spectra of Single-Walled Carbon Nanotube Enantiomers
2015 / JACS
To better understand the sequence–structure–function relationships that control the activity and selectivity of membrane-permeabilizing peptides, we screened a peptide library,… Continue reading Conformational Fine-Tuning of Pore-Forming Peptide Potency and Selectivity
2015 / JACS
Supramolecular symmetry breaking, in which chiral assemblies with imbalanced right- and left-handedness emerge from achiral molecular building blocks, has been… Continue reading Symmetry Breaking in the Supramolecular Gels of an Achiral Gelator Exclusively Driven by π−π Stacking
2015 / ACS Applied Materials and Interfaces
Natural antibodies are used widely for important applications such as biomedical analysis, cancer therapy, and directed drug delivery, but they… Continue reading Antibody-like Biorecognition Sites for Proteins from Surface Imprinting on Nanoparticles
2015 / ACS Applied Materials and Interfaces
Stabilization and electrical contacting of redox enzymes with electrodes are fundamental requirements for bioelectronics devices, including biosensors and enzyme fuel… Continue reading Tuning Structural Changes in Glucose Oxidase for Enzyme Fuel Cell Applications
2015 / ACS Applied Materials and Interfaces
Bacterial infection associated with indwelling medical devices and implants is a major clinical issue, and the prevention or treatment of… Continue reading Toward Infection-Resistant Surfaces: Achieving High Antimicrobial Peptide Potency by Modulating the Functionality of Polymer Brush and Peptide
2016 / ACS Nano
Noncompressible torso hemorrhage is a leading cause of mortality in civilian and battlefield trauma. We sought to develop an i.v.-injectable,… Continue reading Tissue-Factor Targeted Peptide Amphiphile Nanofibers as an Injectable Therapy To Control Hemorrhage
2016 / Biomacromolecules
A novel human ferritin-based nanocarrier, composed of 24 modified monomers able to auto-assemble into a modified protein cage, was produced… Continue reading Improved Doxorubicin Encapsulation and Pharmacokinetics of Ferritin−Fusion Protein Nanocarriers Bearing Proline, Serine, and Alanine Elements
2015 / Biochemistry
Kanamycin is an aminoglycoside antibiotic used in the treatment of drug-resistant tuberculosis. Mutations at the rRNA A-site have been associated… Continue reading Effect of Mutations on the Binding of Kanamycin‑B to RNA Hairpins Derived from the Mycobacterium tuberculosis Ribosomal A‑Site
2015 / Langmuir
The interaction of graphene oxide (GO) with bovine serum albumin (BSA) in aqueous buffer solution has been investigated with various… Continue reading Spectroscopy and Fluorescence Lifetime Imaging Microscopy To Probe the Interaction of Bovine Serum Albumin with Graphene Oxide
2016 / Macromolecules
Synthetic polymers mimicking the stimuli-responsive coiled-coil structures of naturally occurring macromolecules such as motor proteins remain challenging. Here we report… Continue reading Cyclopolymerization of Disiloxane-Tethered Divinyl Monomers To Synthesize Chirality-Responsive Helical Polymers
2016 / Biomacromolecules
Peptide hydrogels are a highly promising class of materials for biomedical application, albeit facing many challenges with regard to stability… Continue reading Mixed alpha-beta peptides as a class of short amphipathic peptide hydrogelators with enhanced proteolytic stability
2016 / Protein Science
In vitro protein stability studies are commonly conducted via thermal or chemical denaturation/renaturation of protein. Conventional data analyses on the protein… Continue reading Using a second-order differential (SOD) model to fit data without baselines in protein isothermal chemical denaturation
2016 / Biotechnology and Bioengineering
Over the past decades, PEGylation has become a powerful technique to increase the in vivo circulation half-life of therapeutic proteins… Continue reading Integrated process for high conversion and high yield protein PEGylation
2016 / European Journal of Organic Chemistry
A new chiral calix[4]arene constructed from asymmetric substitution on bridging methylenes, phenyl rings, and (or) oxygen atoms was tentatively named… Continue reading Bridging Chiral Calix[4]arenes: Description, Optical Resolution, and Absolute Configuration Determination
2016 / Genome Research
The CRISPR/Cas technology enables targeted genome editing and the rapid generation of transgenic animal models for the study of human… Continue reading Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice
