Circular Dichroism Archives

Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α‑Synuclein Aggregation and Toxicity

2016 / ACS Chemical Biology

The reversible modification of protein by the small protein ubiquitin and other ubiquitin-like modifiers plays important roles in virtually every… Continue reading Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α‑Synuclein Aggregation and Toxicity

Stabilization of a-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity

2016 / Biochemistry

Protein misfolding results in the accumulation of aggregated β-sheet-rich structures in Parkinson’s disease (PD) and Alzheimer’s disease. The toxic oligomer… Continue reading Stabilization of a-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity

Covalent Labeling Denaturation Mass Spectrometry for Sensitive Localized Higher Order Structure Comparisons

2016 / Analytical Chemistry

Protein higher order structure (HOS) describes the three-dimensional folding arrangement of a given protein and plays critical roles in structure/function… Continue reading Covalent Labeling Denaturation Mass Spectrometry for Sensitive Localized Higher Order Structure Comparisons

In silico design of short peptides as sensing elements for phenolic compounds

2016 / ACS Sensors

We have exploited a recently developed computational approach [Gladich et al., J. Chem. Phys. B 2015; DOI: 10.1021/acs.jpcb.5b06227] to design cyclic peptides… Continue reading In silico design of short peptides as sensing elements for phenolic compounds

Flexible vs Rigid Epitope Conformations for Diagnostic- and Vaccine Oriented Applications: Novel Insights from the Burkholderia pseudomallei BPSL2765 Pal3 Epitope

2016 / ACS Infectious Diseases

Peptides seldom retain stable conformations if separated from their native protein structure. In an immunological context, this potentially affects the… Continue reading Flexible vs Rigid Epitope Conformations for Diagnostic- and Vaccine Oriented Applications: Novel Insights from the Burkholderia pseudomallei BPSL2765 Pal3 Epitope

Adsorption and Unfolding of a Single Protein Triggers Nanoparticle Aggregation

2016 / ACS Nano

The response of living systems to nanoparticles is thought to depend on the protein corona, which forms shortly after exposure… Continue reading Adsorption and Unfolding of a Single Protein Triggers Nanoparticle Aggregation

Dendritic Elastin-like Peptides: The Effect of Branching on Thermoresponsiveness

2016 / Biomacromolecules

Elastin-like peptides (ELPs) have been used widely to confer thermoresponsive characteristics onto various materials, but to this point mostly linear… Continue reading Dendritic Elastin-like Peptides: The Effect of Branching on Thermoresponsiveness

Solvent-Free Lipase-Catalyzed Synthesis: Unique Properties of Enantiopure D- and L- Polyaspartates and Their Complexation

2016 / Biomacromolecules

Amino acids are attractive monomers for the large-scale preparation of chiral polyamides. For enzymatic polymerization of amino acids using protease… Continue reading Solvent-Free Lipase-Catalyzed Synthesis: Unique Properties of Enantiopure D- and L- Polyaspartates and Their Complexation

Skin Penetrating Peptide as a Tool to Enhance the Permeation of Heparin through Human Epidermis

2016 / Biomacromolecules

This study aimed to identify a new skin penetrating peptide (SPP) able to enhance unfractionated heparin (UFH) permeation through human… Continue reading Skin Penetrating Peptide as a Tool to Enhance the Permeation of Heparin through Human Epidermis

Poly(alanine): Structure and Stability of the D and L‑Enantiomers

2016 / Biomacromolecules

High-performance, biobased materials can potentially be manufactured from polymerized α-amino acids (α-polypeptides). This paper reports on the synthesis, structure, and… Continue reading Poly(alanine): Structure and Stability of the D and L‑Enantiomers

The role of electrostatic interactions in folding of b-proteins

2016 / JACS

Atomic-level molecular dynamic simulations are capable of fully folding structurally diverse proteins; however, they are limited in their ability to… Continue reading The role of electrostatic interactions in folding of b-proteins

A Secreted Ankyrin-Repeat Protein from Clinical Stenotrophomonas maltophilia Isolates Disrupts Actin Cytoskeletal Structure

2016 / ACS Infectious Diseases

Stenotrophomonas maltophilia is an emerging, multidrug-resistant pathogen of increasing importance for the immunocompromised, including cystic fibrosis patients. Despite its significance as… Continue reading A Secreted Ankyrin-Repeat Protein from Clinical Stenotrophomonas maltophilia Isolates Disrupts Actin Cytoskeletal Structure

A Potent D-protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable and Longer-Circulating In Vivo

2016 / ACS Chemical Biology

Polypeptides composed entirely of d-amino acids and the achiral amino acid glycine (d-proteins) inherently have in vivo properties that are proposed to be… Continue reading A Potent D-protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable and Longer-Circulating In Vivo

Excess-Electron Transfer in DNA by Fluctuation-Assisted Hopping Mechanism

2016 / Journal Physical Chemistry B

The dynamics of excess-electron transfer in DNA has attracted the attention of scientists from all kinds of research fields because… Continue reading Excess-Electron Transfer in DNA by Fluctuation-Assisted Hopping Mechanism

Circular Dichroism and Magnetic Circular Dichroism Studies of the Biferrous Site of the Class Ib Ribonucleotide Reductase from Bacillus cereus: Comparison to the Class Ia Enzymes

2008 / Biochemistry

The rate limiting step in DNA biosynthesis is the reduction of ribonucleotides to form the corresponding deoxyribonucleotides. This reaction is… Continue reading Circular Dichroism and Magnetic Circular Dichroism Studies of the Biferrous Site of the Class Ib Ribonucleotide Reductase from Bacillus cereus: Comparison to the Class Ia Enzymes

Characterization of Kinetic Folding Intermediates of Recombinant Canine Milk Lysozyme by Stopped-Flow Circular Dichroism

2005 / Biochemistry

The intermediate in the equilibrium unfolding of canine milk lysozyme induced by a denaturant is known to be very stable… Continue reading Characterization of Kinetic Folding Intermediates of Recombinant Canine Milk Lysozyme by Stopped-Flow Circular Dichroism

CD and MCD Studies of Mouse Ribonucleotide Reductase

2003 / Biochemistry

Ribonucleotide reductase (RNR) catalyzes the synthesis of the four deoxyribonucleotides needed for DNA synthesis and repair in living organisms. The… Continue reading CD and MCD Studies of Mouse Ribonucleotide Reductase

Circular Dichroism and Magnetic Circular Dichroism Studies of the Active Site of p53R2 from Human and Mouse: Iron Binding and Nature of the Biferrous Site Relative to Other Ribonucleotide Reductases

2006 / Biochemistry

Ribonucleotide reductases (RNR) catalyze the rate-limiting step in the synthesis of deoxyribonucleotides from the corresponding ribonucleotides in the synthesis of… Continue reading Circular Dichroism and Magnetic Circular Dichroism Studies of the Active Site of p53R2 from Human and Mouse: Iron Binding and Nature of the Biferrous Site Relative to Other Ribonucleotide Reductases

The Conformational Manifold of Ferricytochrome c Explored by visible and far-UV electronic circular dichroism spectroscopy

2008 / Biochemistry

The oxidized state of cytochrome c is a subject of continuous interest, owing to the multitude of conformations which the protein can… Continue reading The Conformational Manifold of Ferricytochrome c Explored by visible and far-UV electronic circular dichroism spectroscopy

The Nedd4−1 WW Domain Recognizes the PY Motif Peptide through Coupled Folding and Binding Equilibria

2015 / Biochemistry

The four WW domains of human Nedd4–1 (neuronal precursor cell expressed developmentally downregulated gene 4–1) interact with the PPxY (PY)… Continue reading The Nedd4−1 WW Domain Recognizes the PY Motif Peptide through Coupled Folding and Binding Equilibria

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Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α‑Synuclein Aggregation and Toxicity

Stabilization of a-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity

Covalent Labeling Denaturation Mass Spectrometry for Sensitive Localized Higher Order Structure Comparisons

In silico design of short peptides as sensing elements for phenolic compounds

Flexible vs Rigid Epitope Conformations for Diagnostic- and Vaccine Oriented Applications: Novel Insights from the Burkholderia pseudomallei BPSL2765 Pal3 Epitope

Adsorption and Unfolding of a Single Protein Triggers Nanoparticle Aggregation

Dendritic Elastin-like Peptides: The Effect of Branching on Thermoresponsiveness

Solvent-Free Lipase-Catalyzed Synthesis: Unique Properties of Enantiopure D- and L- Polyaspartates and Their Complexation

Skin Penetrating Peptide as a Tool to Enhance the Permeation of Heparin through Human Epidermis

Poly(alanine): Structure and Stability of the D and L‑Enantiomers

The role of electrostatic interactions in folding of b-proteins

A Secreted Ankyrin-Repeat Protein from Clinical Stenotrophomonas maltophilia Isolates Disrupts Actin Cytoskeletal Structure

A Potent D-protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable and Longer-Circulating In Vivo

Excess-Electron Transfer in DNA by Fluctuation-Assisted Hopping Mechanism

Circular Dichroism and Magnetic Circular Dichroism Studies of the Biferrous Site of the Class Ib Ribonucleotide Reductase from Bacillus cereus: Comparison to the Class Ia Enzymes

Characterization of Kinetic Folding Intermediates of Recombinant Canine Milk Lysozyme by Stopped-Flow Circular Dichroism

CD and MCD Studies of Mouse Ribonucleotide Reductase

Circular Dichroism and Magnetic Circular Dichroism Studies of the Active Site of p53R2 from Human and Mouse: Iron Binding and Nature of the Biferrous Site Relative to Other Ribonucleotide Reductases

The Conformational Manifold of Ferricytochrome c Explored by visible and far-UV electronic circular dichroism spectroscopy

The Nedd4−1 WW Domain Recognizes the PY Motif Peptide through Coupled Folding and Binding Equilibria

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