High-throughput screening of stabilizers for Respiratory Syncytial Virus: Identification of stabilizers and their effects on the conformational thermostability of viral particles

2007 / Human Vaccines

Respiratory syncytial virus (RSV) is the leading cause of severe respiratory infection inchildren worldwide. Recombinant live attenuated viral preparations are… Continue reading High-throughput screening of stabilizers for Respiratory Syncytial Virus: Identification of stabilizers and their effects on the conformational thermostability of viral particles

Leah Pandiscia, PhD

Insights on the interaction of phenothiazinium dyes methylene blue and new methylene blue with synthetic duplex RNAs through spectroscopy and modeling

2020 / Journal of Photochemistry and Photobiology B: Biology

The ubiquitous influence of double stranded RNAs in biological events makes them imperative to gather data based on specific binding… Continue reading Insights on the interaction of phenothiazinium dyes methylene blue and new methylene blue with synthetic duplex RNAs through spectroscopy and modeling

Leah Pandiscia, PhD

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

2020 / Cell Research

The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to… Continue reading Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Leah Pandiscia, PhD

Extraordinary Circularly Polarized Luminescence Activity Exhibited by Cesium Tetrakis(3-heptafluoro-butylryl-(+)-camphorato) Eu(III) Complexes in EtOH and CHCl3 Solutions

2008 / JACS

The largest CPL activity ever measured was observed for cesium tetrakis(3-heptafluoro-butylryl-(+)-camphorato) Eu(III) complexes in EtOH and CHCl3 solutions substantiating the stereospecific… Continue reading Extraordinary Circularly Polarized Luminescence Activity Exhibited by Cesium Tetrakis(3-heptafluoro-butylryl-(+)-camphorato) Eu(III) Complexes in EtOH and CHCl3 Solutions

Leah Pandiscia, PhD

pH Dependent Chiroptical Properties of (1R,2R)- and (1S,2S)-trans-Cyclohexane Diesters and Diamides from VCD, ECD, and CPL Spectroscopy

2016 / Journal of Physical Chemistry B

Diesters of (1R,2R)- and (1S,2S)-cyclohexanediols and diamides of (1R,2R)- and (1S,2S)-diaminocyclohexane with p-hydroxycinnamic acid have been known for some time to… Continue reading pH Dependent Chiroptical Properties of (1R,2R)- and (1S,2S)-trans-Cyclohexane Diesters and Diamides from VCD, ECD, and CPL Spectroscopy

Leah Pandiscia, PhD

Swapping Circularly Polarised Luminescence of Eu(III)‐Binaphthyl Hybridized Luminophore with and without Oxymethylene Spacer

2017 / Chemistry Select

Chiroptical signs in circularly polarised luminescence (CPL) of Eu(III) luminophores coordinated to C2‐symmetric binaphthyl ring carrying carboxylic acids, (R)‐1 (and (S)‐1)) and… Continue reading Swapping Circularly Polarised Luminescence of Eu(III)‐Binaphthyl Hybridized Luminophore with and without Oxymethylene Spacer

Leah Pandiscia, PhD

Solvent-sensitive signs and magnitudes of circularly polarised luminescence and circular dichroism spectra: probing two phenanthrenes as emitters endowed with BINOL derivatives

2018 / Organic & Biomolecular Chemistry

A C2-symmeric binaphthyl framework bearing phenanthrene as the emitter exhibited circularly polarised luminescence (CPL) in dilute solutions. The CPL and circular… Continue reading Solvent-sensitive signs and magnitudes of circularly polarised luminescence and circular dichroism spectra: probing two phenanthrenes as emitters endowed with BINOL derivatives

Leah Pandiscia, PhD

Concentration-dependent circularly polarized luminescence (CPL) of chiral N,N′-dipyrenyldiamines: sign-inverted CPL switching between monomer and excimer regions under retention of the monomer emission for photoluminescence

2017 / Chemical Communications

Herein, an unprecedented switching of circularly polarized luminescence (CPL) is described for chiral 4,6-bis(1-(pyren-1-ylamino)propyl)dibenzo[b,d]furan (1). The CPL band of chiral… Continue reading Concentration-dependent circularly polarized luminescence (CPL) of chiral N,N′-dipyrenyldiamines: sign-inverted CPL switching between monomer and excimer regions under retention of the monomer emission for photoluminescence

Leah Pandiscia, PhD

Functional and structural analysis of trehalose-6-phosphate phosphatase from Burkholderia pseudomallei: Insights into the catalytic mechanism

2020 / Biochemical and Biophysical Research Communications

We report the functional and structural characterization of trehalose-6-phosphate phosphatase (TPP), from the Gram-negative bacterium B. pseudomallei that causes melioidosis,… Continue reading Functional and structural analysis of trehalose-6-phosphate phosphatase from Burkholderia pseudomallei: Insights into the catalytic mechanism

Leah Pandiscia, PhD