2023 / Nature Communications
The RNA binding protein TDP-43 forms cytoplasmic inclusions via its C-terminal prion-like domain in several neurodegenerative diseases. Aberrant TDP-43 aggregation… Continue reading Metamorphism in TDP-43 prion-like domain determines chaperone recognition
2023 / Nature Communications
The tumor suppressor BRCA2 participates in DNA double-strand break repair by RAD51-dependent homologous recombination and protects stressed DNA replication forks… Continue reading DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation
2023 / The ISME Journal
Dimethylsulfoniopropionate (DMSP) is a ubiquitous organosulfur compound in marine environments with important functions in both microorganisms and global biogeochemical carbon… Continue reading Ubiquitous occurrence of a dimethylsulfoniopropionate ABC transporter in abundant marine bacteria
2023 / Chirality
2-Amino[2.2]paracyclophane reacts with salicylaldehyde or 2-hydroxyacetophenone to yield imines that then give access to a new series of boranils (8b–d)… Continue reading Synthesis, structural characterization, and chiroptical properties of planarly and axially chiral boranils
2023 / Advanced science
Conditional control of RNA structure and function has emerged as an effective toolkit. Here, a strategy based on a one-step… Continue reading Chemical Control of CRISPR Gene Editing via Conditional Diacylation Crosslinking of Guide RNAs
2023 / Peptide science
Bacterial biofilm formation remains a serious problem for clinical materials and often leads to implant failure. To counteract bacterial adhesion,… Continue reading Rational design of bifunctional chimeric peptides that combine antimicrobial and titanium binding activity
2023 / Advanced Sustainable Systems
Artificial functional materials based on amyloid fibrils are proven to be a promising strategy toward functional materials. However, scaling-up applications… Continue reading Plant Protein Amyloid Fibrils for Multifunctional Sustainable Materials
2023 / ChemPhysChem
The single alpha helix (SAH) is a recurring motif in biology. The consensus sequence has a di-block architecture that includes… Continue reading Uncovering the Contributions of Charge Regulation to the Stability of Single Alpha Helices
2023 / Bioengineering & Translational Medicine
This research examined the possible pathway of monosaccharide production from the rice straw waste using three integrated enzymatic hydrolysis approaches:… Continue reading Injectable sustained-release poly(lactic-co-glycolic acid) (PLGA) microspheres of exenatide prepared by supercritical fluid extraction of emulsion process based on a design of experiment approach
2023 / Nature Communications
hnRNPDL is a ribonucleoprotein (RNP) involved in transcription and RNA-processing that hosts missense mutations causing limb-girdle muscular dystrophy D3 (LGMD… Continue reading Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3
2023 / Communication Biology
Transcription depends on complex networks, where folded hub proteins interact with intrinsically disordered transcription factors undergoing coupled folding and binding.… Continue reading Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime
2023 / Scientific Reports
The assembly state of enzymes is gaining interest as a mechanism for regulating the function of enzymes in living cells.… Continue reading Activation of L-lactate oxidase by the formation of enzyme assemblies through liquid–liquid phase separation
2023 / Scientific Reports
The synthetic peptide ERα17p (sequence: PLMIKRSKKNSLALSLT), which corresponds to the 295–311 region of the human estrogen receptor α (ERα), induces… Continue reading Identification of a human estrogen receptor α tetrapeptidic fragment with dual antiproliferative and anti-nociceptive action
2023 / Scientific Reports
Cathelicidin antimicrobial peptides have an extended and/or unstructured conformation in aqueous solutions but fold into ordered conformations, such as the… Continue reading Discovery of structural and functional transition sites for membrane-penetrating activity of sheep myeloid antimicrobial peptide-18
2022 / Small Structures
As a de novo design of artificial enzymes, peptide assembly is receiving enormous attention. However, the development of durable peptide-based biocatalysts… Continue reading Covalently Self-Assembled Peptide-Based Hydrolase Mimic for Realizing Exceptional Catalytic Longevity in Foreign Environments
2023 / The FEBS Journal
Rieske monooxygenases undertake complex catalysis integral to marine, terrestrial and human gut-ecosystems. Group-I to -IV Rieske monooxygenases accept aromatic substrates… Continue reading Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenase CntA catalytic site
2023 / Carbon Energy
The conversion of CO2 into fuels and valuable chemicals is one of the central topics to combat climate change and… Continue reading Direct detection of a single [4Fe-4S] cluster in a tungsten-containing enzyme: Electrochemical conversion of CO2 into formate by formate dehydrogenase
2023 / Chirality
The interest for chiral tris(β-diketonato)lanthanide complexes in coordination chemistry is huge due to its Lewis acid character, optical activity, and… Continue reading Bulky anion effect on the architecture of chiral dysprosium single-molecule magnets
2022 / Structural Biology
Periplasmic binding proteins (PBPs) are a class of proteins that participate in the cellular transport of various ligands. They have… Continue reading Structures of permuted halves of a modern ribose-binding protein
2022 / Journal of Surfactants And Detergents
The objective of this study is to demonstrate that melittin, a well-studied antimicrobial peptide (AMP), can be solubilized in an… Continue reading Assessment of antimicrobial activity of melittin encapsulated in bicontinuous microemulsions prepared using renewable oils
