Exploration of the Stabilization Mechanism and Curcumin Bioaccessibility of Emulsions Stabilized by Whey Protein Hydrolysates after Succinylation and Glycation in Different Orders

2020 / Journal of Agriculture and Food Chemistry

The combined effects of succinic anhydride (SA) succinylation and linear dextrin (LD) glycation on whey protein hydrolysates (WPH) and their… Continue reading Exploration of the Stabilization Mechanism and Curcumin Bioaccessibility of Emulsions Stabilized by Whey Protein Hydrolysates after Succinylation and Glycation in Different Orders

Leah Pandiscia, PhD

Structural and functional basis for increased HDL-cholesterol levels due to the naturally occurring V19L mutation in human apolipoprotein A-I

2020 / Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Several hereditary point mutations in human apolipoprotein A-I (apoA-I) have been associated with low HDL-cholesterol levels and/or increased coronary artery… Continue reading Structural and functional basis for increased HDL-cholesterol levels due to the naturally occurring V19L mutation in human apolipoprotein A-I

Leah Pandiscia, PhD

Assessing the effect of aromatic residue placement on the α-helical peptide structure and nanofibril formation of 21-mer peptides

2020 / Molecular Systems Design & Engineering

Coiled-coils with defined assembly properties are attractive materials for the manufacture of peptide-based hybrid nanomaterials. In tailoring such peptide assemblies,… Continue reading Assessing the effect of aromatic residue placement on the α-helical peptide structure and nanofibril formation of 21-mer peptides

Leah Pandiscia, PhD

Selective binding of a bioactive porphyrin-based photosensitizer to the G-quadruplex from the KRAS oncogene promoter

2020 / International Journal of Biological Macromolecules

The G-quadruplex-forming sequence within the KRAS proto-oncogene P1 promoter is a promising target for anticancer therapy. Porphyrin derivatives are among… Continue reading Selective binding of a bioactive porphyrin-based photosensitizer to the G-quadruplex from the KRAS oncogene promoter

Leah Pandiscia, PhD

Synthesis and Thermoresponsive Properties of Biocompatible and Biodegradable Triblock Copolymers Bearing Linear or Y‐Shaped OEG Pendants

2019 / Macromolecular Chemistry and Physics

Biocompatible and biodegradable thermoresponsive polymers are of great interest in “smart” biomedical applications. Herein, triblock copolymers (6a and 6b) comprised… Continue reading Synthesis and Thermoresponsive Properties of Biocompatible and Biodegradable Triblock Copolymers Bearing Linear or Y‐Shaped OEG Pendants

Leah Pandiscia, PhD

Optical assessment of chiral–achiral polymer blends based on surface plasmon resonance effects of gold nanoparticles

2019 / Journal of Physics D: Applied Physics

In this research, we investigated the chiroptical properties of chiral–achiral polymer blends consisting of poly[(9,9-bis((S)-3,7-dimethyloctyl)-9H-fluoren-2,7-diyl)-alt-(4-phenylene)] and poly[(9,9-di-n-octylfluorenyl-2,7-diyl)-alt-(benzo[2,1,3]thiadiazol-4,8-diyl)] (PFPh-F8BT). The chirality… Continue reading Optical assessment of chiral–achiral polymer blends based on surface plasmon resonance effects of gold nanoparticles

Leah Pandiscia, PhD

Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer

2020 / Journal of Controlled Release

Metastatic triple-negative breast cancer is one of the most devastating cancer types. Systemic chemotherapy is necessary, but its clinical performance… Continue reading Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer

Leah Pandiscia, PhD

Ratiometric Multicolor Analysis of Intracellular MicroRNA Using a Chain Hybrid Substitution-Triggered Self-Assembly of Silver Nanocluster-Based Label-Free Sensing Platform

2019 / ACS Applied Materials & Interfaces

A simple and label-free sensing platform with low background based on the chain-displacement triggered self-assembly of Ag NCs was developed… Continue reading Ratiometric Multicolor Analysis of Intracellular MicroRNA Using a Chain Hybrid Substitution-Triggered Self-Assembly of Silver Nanocluster-Based Label-Free Sensing Platform

Leah Pandiscia, PhD