Fluoroquinolone antibiotics (FQs), a new class of pollutants that seriously threaten human health through environmental and food residues, have aroused… Continue reading Profiling the interaction of Al(III)-GFLX complex, a potential pollution risk, with bovine serum albumin
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Despite all the attempts to create advanced hemoglobin (Hb)‐based oxygen carriers (HBOCs) employing an encapsulation platform, major challenges including attaining… Continue reading Low‐Fouling Electrosprayed Hemoglobin Nanoparticles with Antioxidant Protection as Promising Oxygen Carriers
Leah Pandiscia, PhD
March 24, 2020
Several hereditary point mutations in human apolipoprotein A-I (apoA-I) have been associated with low HDL-cholesterol levels and/or increased coronary artery… Continue reading Structural and functional basis for increased HDL-cholesterol levels due to the naturally occurring V19L mutation in human apolipoprotein A-I
Leah Pandiscia, PhD
March 24, 2020
To reveal the characteristics of tetracycline (TC) photocatalytic degradation under Cu(II) coexistence, effects of Cu(II) on TC photocatalytic degradation by… Continue reading Effects of divalent copper on tetracycline degradation and the proposed transformation pathway
Leah Pandiscia, PhD
June 29, 2020
Nickel ions are crucial components for the catalysis of biological reactions in prokaryotic organisms. As an uncontrolled nickel trafficking is… Continue reading SrnR from Streptomyces griseus is a nickel-binding transcriptional activator
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
The significant application potential of the DNAzyme activity of G-quadruplex (G4)–hemin complexes has prompted considerable research efforts to amplify their… Continue reading Carbon dot mediated G quadruplex nano-network formation for enhanced DNAzyme activity and easy catalyst reclamation
Leah Pandiscia, PhD
March 24, 2020
Neurodegenerative diseases are an enormous public health problem, affecting tens of millions of people worldwide. Nearly all of these diseases… Continue reading PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins
Leah Pandiscia, PhD
March 24, 2020
Hybrid nanoparticles composed of cellulose nanocrystals (CNCs) and carbon‐dots (C‐dots) have promising applications in chemistry, biology, and nanomedicine, owing to… Continue reading Chiral Carbon Dots Synthesized on Cellulose Nanocrystals
Leah Pandiscia, PhD
March 24, 2020
Coiled-coils with defined assembly properties are attractive materials for the manufacture of peptide-based hybrid nanomaterials. In tailoring such peptide assemblies,… Continue reading Assessing the effect of aromatic residue placement on the α-helical peptide structure and nanofibril formation of 21-mer peptides
Leah Pandiscia, PhD
March 24, 2020
The G-quadruplex-forming sequence within the KRAS proto-oncogene P1 promoter is a promising target for anticancer therapy. Porphyrin derivatives are among… Continue reading Selective binding of a bioactive porphyrin-based photosensitizer to the G-quadruplex from the KRAS oncogene promoter
Leah Pandiscia, PhD
March 24, 2020
Biocompatible and biodegradable thermoresponsive polymers are of great interest in “smart” biomedical applications. Herein, triblock copolymers (6a and 6b) comprised… Continue reading Synthesis and Thermoresponsive Properties of Biocompatible and Biodegradable Triblock Copolymers Bearing Linear or Y‐Shaped OEG Pendants
Leah Pandiscia, PhD
March 24, 2020
Biophysical insight into the binding interaction between the major whey protein, β-Lactoglobulin (βLG) and vitamin B12, was studied using different… Continue reading Biophysical study on complex formation between β-Lactoglobulin and vitamin B12
Leah Pandiscia, PhD
March 24, 2020
The FANCJ helicase unfolds G-quadruplexes (G4s) in human cells to support DNA replication. This action is coupled to the recruitment… Continue reading Assembly of a G-Quadruplex Repair Complex by the FANCJ DNA Helicase and the REV1 Polymerase
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Heat shock proteins play roles in assisting other proteins to fold correctly and in preventing the aggregation and accumulation of… Continue reading Human Molecular Chaperone Hsp60 and Its Apical Domain Suppress Amyloid Fibril Formation of α-Synuclein
Leah Pandiscia, PhD
March 24, 2020
In this research, we investigated the chiroptical properties of chiral–achiral polymer blends consisting of poly[(9,9-bis((S)-3,7-dimethyloctyl)-9H-fluoren-2,7-diyl)-alt-(4-phenylene)] and poly[(9,9-di-n-octylfluorenyl-2,7-diyl)-alt-(benzo[2,1,3]thiadiazol-4,8-diyl)] (PFPh-F8BT). The chirality… Continue reading Optical assessment of chiral–achiral polymer blends based on surface plasmon resonance effects of gold nanoparticles
Leah Pandiscia, PhD
March 24, 2020
Metastatic triple-negative breast cancer is one of the most devastating cancer types. Systemic chemotherapy is necessary, but its clinical performance… Continue reading Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020