2022 / Biopolymers
Growing interest in i-motif DNA as a transcriptional regulatory element motivates development of synthetic molecules capable of targeting these structures.… Continue reading Targeting a KRAS i-motif forming sequence by unmodified and gamma-modified peptide nucleic acid oligomers
2022 / Journal of Polymer Science
We report the first example of a chiral polymer—cellulose—being dissolved in both enantiomers of a chiral solvent. We synthesized six… Continue reading Lactate-based ionic liquids as chiral solvents for cellulose
2022 / Advanced Science
The rapid dissemination of antibiotic resistance accelerates the desire for new antibacterial agents. Here, a class of antimicrobial peptides (AMPs)… Continue reading Combating Escherichia coli O157:H7 with Functionalized Chickpea-Derived Antimicrobial Peptides
2022 / The FASEB Journal
Bone morphogenetic proteins (BMP) are powerful regulators of cellular processes such as proliferation, differentiation, and apoptosis. However, the specific molecular… Continue reading Targeting of bone morphogenetic protein complexes to heparin/heparan sulfate glycosaminoglycans in bioactive conformation
2023 / Nature Communications
The discrimination of enantiomers by natural receptors is a well-established phenomenon. In contrast the number of synthetic receptors with the… Continue reading Preferential molecular recognition of heterochiral guests within a cyclophane receptor
2023 / Nature Communications
Bio-inspired self-assembly is invaluable to create well-defined giant structures from small molecular units. Owing to a large entropy loss in… Continue reading Symmetry-breaking host–guest assembly in a hydrogen-bonded supramolecular system
2023 / Nature Communications
The development of circularly polarized luminescence (CPL)-active materials with both large luminescence dissymmetry factor (glum) and high emission efficiency continues… Continue reading Enhanced chiroptic properties of nanocomposites of achiral plasmonic nanoparticles decorated with chiral dye-loaded micelles
2023 / Nature Communications
Differential sensing attempts to mimic the mammalian senses of smell and taste to identify analytes and complex mixtures. In place… Continue reading Differential sensing with arrays of de novo designed peptide assemblies
2023 / Scientific Reports
Fibroblast growth factor 21 (FGF21) has pharmaceutical potential against obesity-related metabolic disorders, including non-alcoholic fatty liver disease. Since thermal stability… Continue reading Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency
2022 / ACS Nano
Chiroptically active, hierarchically structured materials are difficult to accurately characterize due to linear anisotropic contributions (i.e., linear dichroism (LD) and… Continue reading Extracting Pure Circular Dichroism from Hierarchically Structured CdS Magic Cluster Films
2022 / JACS
The amplification of molecular asymmetry through self-assembly is a phenomenon that not only comprehends the origin of homochirality in nature… Continue reading Amplification of Molecular Asymmetry during the Hierarchical Self-Assembly of Foldable Azobenzene Dyads into Nanotoroids and Nanotubes
2022 / Journal of Medical Chemistry
A series of small (7–12 mer) amphipathic cationic peptides were designed and synthesized to create short helical peptides with broad-range… Continue reading Structure-Based Rational Design of Small α-Helical Peptides with Broad-Spectrum Activity against Multidrug-Resistant Pathogens
2022 / Nature Communications
The developments of pure organic room-temperature phosphorescence (RTP) materials with circularly polarized luminescence (CPL) have significantly facilitated the future integration… Continue reading Photoprogrammable circularly polarized phosphorescence switching of chiral helical polyacetylene thin films
2022 / Scientific Reports
Anastellin, a recombinant protein fragment from the first type III module of fibronectin, mimics a partially unfolded intermediate implicated in… Continue reading Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells
2023 / Nature
Cas12a2 is a CRISPR-associated nuclease that performs RNA-guided, sequence-nonspecific degradation of single-stranded RNA, single-stranded DNA and double-stranded DNA following recognition… Continue reading RNA targeting unleashes indiscriminate nuclease activity of CRISPR–Cas12a2
2023 / Nature Communications
The high temperature, acidity, and heavy metal-rich environments associated with hot springs have a major impact on biological processes in resident… Continue reading Genome-wide signatures of adaptation to extreme environments in red algae
2022 / Nucleic Acids Research, Volume 50, Issue W1, 5 July 2022, Pages W90–W98
Circular dichroism (CD) spectroscopy is widely used to characterize the secondary structure composition of proteins. To derive accurate and detailed… Continue reading BeStSel: webserver for secondary structure and fold prediction for protein CD spectroscopy
2022
This paper presents a facile method for fabricating a thin-film sample with a high asymmetry value of induced circularly polarized… Continue reading Circular Polarization Luminescence of Groove Anchor Driving Optically Active Poly(methyl methacrylate) Stereocomplexes
2022 / Nature nanotechnology
Real time monitoring of chirality transfer processes is necessary to better understand their kinetic properties. Herein, we monitor an ideal… Continue reading Real-time chirality transfer monitoring from statistically random to discrete homochiral nanotubes
2022 / Nature communications
Intrinsically disordered proteins rich in cationic amino acid groups can undergo Liquid-Liquid Phase Separation (LLPS) in the presence of charge-balancing… Continue reading Hydrophobicity of arginine leads to reentrant liquid-liquid phase separation behaviors of arginine-rich proteins
