2019 / Vaccine
Outer surface protein A (OspA) is a Borrelia lipoprotein and an established Lyme disease vaccine target. Admixing non-lipidated, recombinant B. burgdorferi OspA with liposomes… Continue reading Immunogenicity of the Lyme disease antigen OspA, particleized by cobalt porphyrin-phospholipid liposomes
2019 / Chemical Physics Letters
The pulsed laser induced transient grating method is a powerful technique for measuring the diffusion coefficient (D) sensitively with a… Continue reading Spiropyran labeling for sensitive probing of protein diffusion by the transient grating method
2019 / Biochimica et Biophysica Acta (BBA) - General Subjects
Tau is the major neuronal protein involved in the stabilization of microtubule assembly. In Alzheimer’s disease, Tau self-assembles to form… Continue reading Melatonin interacts with repeat domain of Tau to mediate disaggregation of paired helical filaments
2020 / Sensors and Actuators B: Chemical
Traditional biotechnology, taking advantage of fluorescent protein (FP) to investigate the foreign protein, was difficult to visualize and image accurately… Continue reading Small molecule fluorescent probe: Illumining and monitoring foreign proteins based on high fidelity imaging in living cells
2019 / Journal of Inorganic Biochemistry
Mucin 7 (called MUC7 or MG2) is a salivary protein whose fragments exhibit a strong antimicrobial activity and is a… Continue reading Human salivary MUC7 mucin fragment and its analogues. Coordination and biological studies
2019 / biomolecules
(1) Background: Metallo-β-lactamases (MBLs) have raised concerns due to their ability to inactivate carbapenems and newer generation cephalosporins and the… Continue reading Mutation S115T in IMP-Type Metallo-β-Lactamases Compensates for Decreased Expression Levels Caused by Mutation S119G
2019 / Analytica Chimica Acta
A biomimetic assembly of per-O-methylated-cyclodextrin dimer with cobalt proto-porphyrin (CoIII-PPIX@Py2CD) was achieved via covalent linkage between CoIII of CoIII-PPIX and pyridine… Continue reading The mimetic assembly of cobalt prot-porphyrin with cyclodextrin dimer and its application for H2O2 detection
2019 / ACS Chemical Neuroscience
The aggregation of amyloid-β (Aβ) into oligomers and fibrillary structures is critical for the pathogenesis of Alzheimer’s disease (AD). Recently,… Continue reading Toward the Mode of Action of the Clinical Stage All-d-Enantiomeric Peptide RD2 on Aβ42 Aggregation
2019 / The Journal of Organic Chemistry
Bacterially expressed proteins used in NMR studies lack glycans, and proteins from other organisms are neither 15N labeled nor glycosylated homogeneously.… Continue reading Production of Artificially Doubly Glycosylated, 15N Labeled Prion Protein for NMR Studies Using a pH-Scanning Volatile Buffer System
2019 / Journal of Raman Spectroscopy
In this work, we demonstrate the underused potential of Raman spectroscopy in detecting formation of DNA G‐quadruplex (G4) and differentiating… Continue reading Does Raman spectroscopy recognize different G‐quadruplex arrangements?
2020 / European Journal of Medicinal Chemistry
The three series of 5-mono- and 2,5-bis-1,2,3-triazolyl-substituted benzimidazo[1,2-a]quinolines as potential antitumor agents were synthesized. Their growth-inhibitory activity is influenced by… Continue reading Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis-(1,2,3-triazolyl)-appended benzimidazo[1,2-a]quinoline derivatives
2019 / Chemistry A European Journal
By applying caged thymidine residues, DNA duplexes were created in which HgII‐mediated base pair formation can be triggered by irradiation… Continue reading Light‐Induced Formation of Thymine‐Containing Mercury(II)‐Mediated Base Pairs
2019 / Journal of Biological Chemistry
The mitochondrial, or intrinsic, apoptosis pathway is regulated mainly by members of the B-cell lymphoma 2 (BCL-2) protein family. BCL-2–associated… Continue reading Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization
2019 / ACS Omega
Following the information obtained by a rational design study, a cyclic and helical-stabilized analogue of the peptide Cm-p5 was synthetized.… Continue reading Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity
2020 / Nanomedicine: Nanotechnology, Biology and Medicine
The flavoenzyme D-amino acid oxidase (DAAO) represents a potentially good option for cancer enzyme prodrug therapy as it produces H2O2 using… Continue reading PEG-DAAO conjugate: A promising tool for cancer therapy optimized by protein engineering
2020 / Biochemical and Biophysical Research Communications
Extra Cytoplasmic Function (ECF) σ factor/regulatory protein (anti-σ factor) pairs govern environment mediated changes in gene expression in bacteria. The… Continue reading Evaluation of specificity determinants in Mycobacterium tuberculosis σ/anti-σ factor interactions
2020 / Food Chemistry
Phosphorylation could improve functional characteristics of proteins/peptides, and might be used in the functional improvement of herring egg peptides owing… Continue reading Calcium binding to herring egg phosphopeptides: Binding characteristics, conformational structure and intermolecular forces
2019 / Advanced Functional Materials
Chirality‐based semiconducting nanocrystals, as an emerging area, are envisioned to have great potential in chiral sensing, biomedicine, and chiroptical devices.… Continue reading A Visible‐ and NIR‐Light Responsive Photothermal Therapy Agent by Chirality‐Dependent MoO3−x Nanoparticles
2019 / Acta Pharmaceutica Sinica B
Twelve new grayanoids (1−12) along with five known compounds were isolated from flowers of Rhododendron molle. Their structures were fully characterized… Continue reading Antinociceptive grayanane-derived diterpenoids from flowers of Rhododendron molle
2020 / European Journal of Medicinal Chemistry
Methionine aminopeptidase 1 of Leishmania donovani (LdMetAP1) is a novel antileishmanial target for its role in vital N-terminal methionine processing. After LdMetAP1 expression… Continue reading Synthesis and characterization of quinoline-carbaldehyde derivatives as novel inhibitors for leishmanial methionine aminopeptidase 1
