Circular Dichroism Archives

Unique Aggregation of Sterigmatocystin in Water Yields Strong and Specific Circular Dichroism Response Allowing Highly Sensitive and Selective Monitoring of Bio-Relevant Interactions

2019 / Marine Drugs

We demonstrated the hitherto unknown property of the mycotoxin sterigmatocystin (STC) to provide homogeneous solutions in aqueous medium by forming… Continue reading Unique Aggregation of Sterigmatocystin in Water Yields Strong and Specific Circular Dichroism Response Allowing Highly Sensitive and Selective Monitoring of Bio-Relevant Interactions

Low-complexity domain of U1-70K modulates phase separation and aggregation through distinctive basic-acidic motif

2019 / Science Advances

Liquid-liquid phase separation (LLPS) facilitates the formation of functional membraneless organelles and recent reports have linked this phenomenon to protein… Continue reading Low-complexity domain of U1-70K modulates phase separation and aggregation through distinctive basic-acidic motif

Artificial covalent linkage of bacterial acyl carrier proteins for fatty acid production

2019 / Scientific Reports

Acyl carrier proteins (ACPs) are essential to the production of fatty acids. In some species of marine bacteria, ACPs are… Continue reading Artificial covalent linkage of bacterial acyl carrier proteins for fatty acid production

Tyrosinase inhibitors from the leaves of Eucalyptus globulus

2019 / Fitoterpia

A new isoiphionane sesquiterpene, named (3S, 5S, 7S, 10R)-3, 11-dihydroxyisoiphion-4-one (1), two new phloroglucinol glycosides, named eucalglobuside A (2) and… Continue reading Tyrosinase inhibitors from the leaves of Eucalyptus globulus

In vitro exploration of interaction behavior between calf thymus DNA and fenhexamid with the help of multi-spectroscopic methods and molecular dynamics simulations

2019 / Journal of Molecular Liquids

As an amide fungicide, fenhexamid has been extensively used to control botrytis and sclerotinia as well as antagonize the resistant… Continue reading In vitro exploration of interaction behavior between calf thymus DNA and fenhexamid with the help of multi-spectroscopic methods and molecular dynamics simulations

Aggregation determines the selectivity of membrane-active anticancer and antimicrobial peptides: The case of killerFLIP

2019 / Biochimica et Biophysica Acta (BBA) - Biomembranes

Host defense peptides selectively kill bacterial and cancer cells (including those that are drug-resistant) by perturbing the permeability of their… Continue reading Aggregation determines the selectivity of membrane-active anticancer and antimicrobial peptides: The case of killerFLIP

Engineering Secretory Amyloids for Remote and Highly Selective Destruction of Metastatic Foci

2019 / Advanced Materials

Functional amyloids produced in bacteria as nanoscale inclusion bodies are intriguing but poorly explored protein materials with wide therapeutic potential.… Continue reading Engineering Secretory Amyloids for Remote and Highly Selective Destruction of Metastatic Foci

EPR and MCD spectra of the nitrogenase M cluster precursor suggest sulfur migration upon oxidation: A proposal for substrate and inhibitor binding

2019 / ChemBioChem

The active site of the nitrogen fixing enzyme, Mo‐nitrogenase, is the M cluster ([MoFe7S9C·R‐homocitrate]), also known as the FeMo cofactor… Continue reading EPR and MCD spectra of the nitrogenase M cluster precursor suggest sulfur migration upon oxidation: A proposal for substrate and inhibitor binding

Evaluation of Charge-Regulated Supramolecular Copolymerization to Tune the Time Scale for Oxidative Disassembly of β-Sheet Comonomers

2019 / Macromolecular Rapid Communications

A multistimuli-responsive supramolecular copolymerization is reported. The copolymerization is driven by hydrogen bond encoded β-sheet-based charge co-assembly into 1D nanorods… Continue reading Evaluation of Charge-Regulated Supramolecular Copolymerization to Tune the Time Scale for Oxidative Disassembly of β-Sheet Comonomers

A new aquatic pathogen inhibitor produced by the marine fungus Aspergillus sp. LS116

2019 / Aquaculture

In this study, a fungal strain LS116 with antibacterial activity against aquatic pathogen Vibrio harveyi was screened out from sponge-associated fungi by… Continue reading A new aquatic pathogen inhibitor produced by the marine fungus Aspergillus sp. LS116

Layer by Layer Antimicrobial Coatings Based on Nafion, Lysozyme, and Chitosan

2019 / Nanomaterials

The study focuses on the development of a new family of layer-by-layer coatings comprising Nafion, lysozyme and chitosan to address… Continue reading Layer by Layer Antimicrobial Coatings Based on Nafion, Lysozyme, and Chitosan

Divalent Cations and Lipid Composition Modulate Membrane Insertion and Cancer-Targeting Action of pHLIP

2019 / Journal of Molecular Biology

The pH-Low Insertion Peptide (pHLIP) has emerged as an important tool for targeting cancer cells; it has been assumed that… Continue reading Divalent Cations and Lipid Composition Modulate Membrane Insertion and Cancer-Targeting Action of pHLIP

Synthesis and Hierarchical Self‐Assembly of Diphenylalanine‐Based Homopolymer and Copolymers By RAFT Polymerization

2019 / Journal of Polymer Science Part A: Polymer Chemistry

Dipeptide diphenylalanine has attracted significant research interests because of its ability to self‐assemble into various nanostructures such as nanotubes, nanowires,… Continue reading Synthesis and Hierarchical Self‐Assembly of Diphenylalanine‐Based Homopolymer and Copolymers By RAFT Polymerization

Structure of the Human ACP-ISD11 Heterodimer

2019 / Biochemistry

In recent years, the mammalian mitochondrial protein complex for iron–sulfur cluster assembly has been the focus of important studies. This… Continue reading Structure of the Human ACP-ISD11 Heterodimer

Cellulose Nanocrystal Elastomers with Reversible Visible Color

2019 / Angewandte Chemie International

Responsive photonic crystals have potential applications in mechanical sensors and soft displays; however, new materials are constantly desired to provide… Continue reading Cellulose Nanocrystal Elastomers with Reversible Visible Color

Understanding the mechanism of copurification of “difficult to remove” host cell proteins in rituximab biosimilar products

2019 / Biotechnology Progess

Host cell proteins (HCPs) are considered a critical quality attribute and are linked to safety and efficacy of biotherapeutic products.… Continue reading Understanding the mechanism of copurification of “difficult to remove” host cell proteins in rituximab biosimilar products

Partition usage of cellulose by coupling approach of supercritical carbon dioxide and cellulase to reducing sugar and nanocellulose

2019 / Carbohydrate Polymers

Cellulose is the most abundant renewable resource on earth, and its economic utilization has long been a hot research topic.… Continue reading Partition usage of cellulose by coupling approach of supercritical carbon dioxide and cellulase to reducing sugar and nanocellulose

Kinetic study of Aβ(1-42) amyloidosis in the presence of ganglioside-containing vesicles

2019 / Colloids and Surfaces B: Biointerfaces

Alzheimer’s disease (AD) is characterized by the amyloid-beta peptide (Aβ) misfolding to form aberrant amyloid aggregates in the brain. Although… Continue reading Kinetic study of Aβ(1-42) amyloidosis in the presence of ganglioside-containing vesicles

The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein

2019 / Biochemical and Biophysical Research Communications

The p53 protein plays a number of roles in protecting organisms from different genotoxic stresses and this includes DNA damage… Continue reading The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein

Designed zwitterionic peptide combined with sacrificial Fe-MOF for low fouling and highly sensitive electrochemical detection of T4 polynucleotide kinase

2019 / Sensors and Actuators B: Chemical

Herein, an antifouling and sensitive electrochemical enzyme sensing platform was developed based on a self-designed zwitterionic peptide and sacrificial iron… Continue reading Designed zwitterionic peptide combined with sacrificial Fe-MOF for low fouling and highly sensitive electrochemical detection of T4 polynucleotide kinase

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