The Escherichia coli SecA ATPase motor protein is essential for secretion of proteins through the SecYEG translocon into the periplasmic space. Its… Continue reading Binding of SecA ATPase monomers and dimers to lipid vesicles
Leah Pandiscia, PhD
March 24, 2020
DJ-1 is a deglycase enzyme which exhibits a redox-sensitive chaperone-like activity. The partially oxidized state of DJ-1 is active in… Continue reading Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Cyclic dinucleotides have emerged as important secondary messengers and cell signaling molecules that regulate several cell responses. A guanine-deficit G-quadruplex… Continue reading Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides
Leah Pandiscia, PhD
March 24, 2020
Protein-based nanoassemblies can encapsulate hydrophobic compounds into their hydrophobic region and effectively improve their aqueous solubility and stability. However, hydrolyzed… Continue reading The construction of enzymolyzed α-lactalbumin based micellar nanoassemblies for encapsulating various kinds of hydrophobic bioactive compounds
Leah Pandiscia, PhD
March 24, 2020
A new lignan, thoreliin A (1), and a new bisnorlignan, thoreliin B (2), were isolated from a MeOH extract of… Continue reading Anti-HIV-1 activities of constituents from the rhizomes of Boesenbergia thorelii
Leah Pandiscia, PhD
June 29, 2020
Snake venom metalloproteinases (SVMPs) are key toxins involved in local inflammatory reactions after snakebites. This study aimed to investigate the… Continue reading Leukocyte recruitment induced by snake venom metalloproteinases: Role of the catalytic domain
Leah Pandiscia, PhD
March 24, 2020
Protein fibrous aggregation is associated with many neurodegenerative diseases including Alzheimer’s and Parkinson’s diseases. To modulate the process, a number… Continue reading Crocein Orange G mediated detection and modulation of amyloid fibrillation revealed by surface-enhanced Raman spectroscopy
Leah Pandiscia, PhD
March 24, 2020
Intracellular proteolysis is attracting more and more attention for its unique and important character in Mycobacterium tuberculosis (Mt). The ClpS protein from Mt (MtClpS)… Continue reading Recombinant expression, biophysical and functional characterization of ClpS from Mycobacterium tuberculosis
Leah Pandiscia, PhD
March 24, 2020
Although it has been demonstrated that membrane proteins (MPs) require lipids to ensure their structural and functional integrity, details on… Continue reading Archaeal Glycolipid S-TGA-1 Is Crucial for Trimer Formation and Photocycle Activity of Bacteriorhodopsin
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
From extracts of the plant associated fungus Chaetosphaeronema achilleae collected in Iran, a previously unreported isoindolinone named chaetosisoindolinone (1) and a previously… Continue reading Cytotoxic, anti-biofilm and antimicrobial polyketides from the plant associated fungus Chaetosphaeronema achilleae
Leah Pandiscia, PhD
June 29, 2020
Leah Pandiscia, PhD
March 24, 2020
A mixture of pheophytins-a/a’, metal-free forms of photosynthetically active chlorophyll(Chl)s-a/a’ bearing the 132-methoxycarbonyl group, was substituted at the C132-position by… Continue reading Synthesis of chlorophyll-a homologs by C132-substitutions and their physico- and biochemical properties
Leah Pandiscia, PhD
March 24, 2020
Repeat-associated non-AUG (RAN) translation is a non-canonical translation initiation event that occurs at nucleotide-repeat expansion mutations that are associated with… Continue reading High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Glycoside hydrolase (GH) 87-type α-1,3-glucanase hydrolyses the α-1,3-glucoside linkages of α-1,3-glucan, which is found in fungal cell walls and extracellular… Continue reading Crystal structure of the catalytic unit of GH 87-type α-1,3-glucanase Agl-KA from Bacillus circulans
Leah Pandiscia, PhD
March 24, 2020
Twelve undescribed sesquiterpenoids, fomitopins A–L (1–12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have… Continue reading Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activity
Leah Pandiscia, PhD
June 29, 2020
The use of biomolecules has been invaluable at generating and controlling optical chirality in nanomaterials; however, the structure and properties… Continue reading Chiral Restructuring of Peptide Enantiomers on Gold Nanomaterials
Leah Pandiscia, PhD
March 24, 2020