2019 / Biochimica et Biophysica Acta (BBA) - Biomembranes
The Escherichia coli SecA ATPase motor protein is essential for secretion of proteins through the SecYEG translocon into the periplasmic space. Its… Continue reading Binding of SecA ATPase monomers and dimers to lipid vesicles
2019 / Communications Biology
DJ-1 is a deglycase enzyme which exhibits a redox-sensitive chaperone-like activity. The partially oxidized state of DJ-1 is active in… Continue reading Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro
2019 / ACS Chemical Neuroscience
Protein misfolding and its deviant self-assembly to converge into amyloid fibrils is associated with the perturbation of cellular functions and… Continue reading Biophysical Elucidation of Amyloid Fibrillation Inhibition and Prevention of Secondary Nucleation by Cholic Acid: An Unexplored Function of Cholic Acid
2019 / JACS
Cyclic dinucleotides have emerged as important secondary messengers and cell signaling molecules that regulate several cell responses. A guanine-deficit G-quadruplex… Continue reading Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides
2019 / Food & Function
Protein-based nanoassemblies can encapsulate hydrophobic compounds into their hydrophobic region and effectively improve their aqueous solubility and stability. However, hydrolyzed… Continue reading The construction of enzymolyzed α-lactalbumin based micellar nanoassemblies for encapsulating various kinds of hydrophobic bioactive compounds
2019 / Fitoterpia
A new lignan, thoreliin A (1), and a new bisnorlignan, thoreliin B (2), were isolated from a MeOH extract of… Continue reading Anti-HIV-1 activities of constituents from the rhizomes of Boesenbergia thorelii
2019 / Biochemical and Biophysical Research Communications
Snake venom metalloproteinases (SVMPs) are key toxins involved in local inflammatory reactions after snakebites. This study aimed to investigate the… Continue reading Leukocyte recruitment induced by snake venom metalloproteinases: Role of the catalytic domain
2020 / Biosensors and Bioelectronics
Protein fibrous aggregation is associated with many neurodegenerative diseases including Alzheimer’s and Parkinson’s diseases. To modulate the process, a number… Continue reading Crocein Orange G mediated detection and modulation of amyloid fibrillation revealed by surface-enhanced Raman spectroscopy
2019 / Acta Biochimica et Biophysica Sinica
Intracellular proteolysis is attracting more and more attention for its unique and important character in Mycobacterium tuberculosis (Mt). The ClpS protein from Mt (MtClpS)… Continue reading Recombinant expression, biophysical and functional characterization of ClpS from Mycobacterium tuberculosis
2019 / ACS Chemical Biology
Although it has been demonstrated that membrane proteins (MPs) require lipids to ensure their structural and functional integrity, details on… Continue reading Archaeal Glycolipid S-TGA-1 Is Crucial for Trimer Formation and Photocycle Activity of Bacteriorhodopsin
2019 / World Journal of Microbiology and Biotechnology
In the two-component system of NisRK from Lactococcus lactis, the production of nisin is affected by transmembrane NisK and activation of… Continue reading Structural and functional evaluation of recombinant histidine phosphokinase NisK and response regulator NisR: in silico and experimental approach
2019 / Fitoterpia
From extracts of the plant associated fungus Chaetosphaeronema achilleae collected in Iran, a previously unreported isoindolinone named chaetosisoindolinone (1) and a previously… Continue reading Cytotoxic, anti-biofilm and antimicrobial polyketides from the plant associated fungus Chaetosphaeronema achilleae
2020 / Phytochemistry
In the present work, we take advantage of the characteristic NMR signal (δC-10 = 96.0–99.9) for guiding the isolation of schinortriterpenoids (SNTs)… Continue reading From extracts of the plant associated fungus Chaetosphaeronema achilleae collected in Iran, a previously unreported isoindolinone named chaetosisoindolinone (1) and a previously undescribed indanone named chaetosindanone (2) were isolated in addition to five known metabolites, 2-(2-acetyl-3,5-dihydroxyphenyl) acetic acid (3), vulculic acid (4), 2-(2-acetyl-3-hydroxy-5-methoxyphenyl)acetic acid (5), curvulin (6), and curvulol (7). Their structures were elucidated on the basis of extensive spectroscopic analysis and high-resolution mass spectrometry. The isolated compounds were tested for their antimicrobial, anti-biofilm, and nematicidal activities. Compound 2 exhibited cytotoxicity against the human breast adenocarcinoma MCF-7 cells with an IC50 value of 1.5 μg/mL. Furthermore, compounds 4 and 7 almost completely inhibited biofilm formation in Staphylococcus aureus at 256 μg/mL. Weak antimicrobial activities were also observed for some of the isolated compounds against Mucor hiemalis, Rhodoturula glutinis, Chromobacterium violaceum, and Staphylococcus aureus.
2019 / biomolecules
Dermaseptins are an antimicrobial peptide family widely identified from the skin secretions of phyllomeudusinae frogs. Here, we identify Dermaseptin-PC (DM-PC),… Continue reading Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients
2019 / Bioorganic Chemistry
A mixture of pheophytins-a/a’, metal-free forms of photosynthetically active chlorophyll(Chl)s-a/a’ bearing the 132-methoxycarbonyl group, was substituted at the C132-position by… Continue reading Synthesis of chlorophyll-a homologs by C132-substitutions and their physico- and biochemical properties
2019 / Journal of Biological Chemistry
Repeat-associated non-AUG (RAN) translation is a non-canonical translation initiation event that occurs at nucleotide-repeat expansion mutations that are associated with… Continue reading High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation
2019 / Bioorganic Chemistry
A small library of cyclic TBA analogues (named cycTBA I-IV), obtained by covalently connecting its 5′- and 3′-ends with flexible linkers,… Continue reading Fine-tuning the properties of the thrombin binding aptamer through cyclization: Effect of the 5′-3′ connecting linker on the aptamer stability and anticoagulant activity
2019 / Scientific Reports
Glycoside hydrolase (GH) 87-type α-1,3-glucanase hydrolyses the α-1,3-glucoside linkages of α-1,3-glucan, which is found in fungal cell walls and extracellular… Continue reading Crystal structure of the catalytic unit of GH 87-type α-1,3-glucanase Agl-KA from Bacillus circulans
2019 / RSC Advances
Twelve undescribed sesquiterpenoids, fomitopins A–L (1–12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have… Continue reading Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activity
2019 / ACS Biomaterials Science & Engineering
The use of biomolecules has been invaluable at generating and controlling optical chirality in nanomaterials; however, the structure and properties… Continue reading Chiral Restructuring of Peptide Enantiomers on Gold Nanomaterials
