Leah Pandiscia, PhD
March 24, 2020
Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive… Continue reading A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization
Leah Pandiscia, PhD
March 24, 2020
Self-assembled supramolecular organic materials with π-functionalities are of great interest because of their applications as biocompatible nanoelectronics. A detailed understanding… Continue reading Controlling Supramolecular Chirality in Peptide−π-Peptide Networks by Variation of the Alkyl Spacer Length
Leah Pandiscia, PhD
March 24, 2020
The present research relates to a fusion protein comprising a chromogenic blue ultramarine protein (UM) bound to a keratin-based peptide… Continue reading Fusion proteins with chromogenic and keratin binding modules
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
The heat-induced aggregation of edible proteins has been regarded as one of the critical challenges for their application in protein-enriched… Continue reading Enhancing the thermal stability of soy proteins by preheat treatment at lower protein concentration
Leah Pandiscia, PhD
March 24, 2020
Biochemical and gelling properties of silver carp surimi as affected by harvesting season and chopping process were investigated. Myosin from… Continue reading Biochemical and gelling properties of silver carp surimi as affected by harvesting season and chopping time
Leah Pandiscia, PhD
March 24, 2020
Solanum indicum var. recurvatum, distributed mainly in Hekou, Simao and Menghai areas of Yunnan province, China, is characterized by stellate pubescent leaves… Continue reading Two new 23S,26R-hydroxylated spirostanoid saponins from the fruits of Solanum indicum var. recurvatum
Leah Pandiscia, PhD
March 24, 2020
The successful management of tuberculosis (TB) requires efficient diagnosis and treatment. Further, the increasing prevalence of drug-resistant TB highlights the… Continue reading Theranostic Application of a Novel G-Quadruplex-Forming DNA Aptamer Targeting Malate Synthase of Mycobacterium tuberculosis
Leah Pandiscia, PhD
March 24, 2020
Microbes serve as the most important resource for drug discovery. During our screening for bioactive compounds from our natural products… Continue reading Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049
Leah Pandiscia, PhD
March 24, 2020
Alzheimer’s disease (AD) is a neurodegenerative disorder caused by protein misfolding, aggregation and accumulation in the brain. A large number… Continue reading Baicalein suppresses Repeat Tau fibrillization by sequestering oligomers
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Web spiders connect silk proteins, so-called spidroins, into fibers of extraordinary toughness. The spidroin N-terminal domain (NTD) plays a pivotal… Continue reading Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk
Leah Pandiscia, PhD
March 24, 2020
We harness a synergy between morphology and the electromagnetic response of semiconducting material to engineer the chiro-optical properties of metamaterials… Continue reading Shape-Dependent, Chiro-optical Response of UV-Active, Nanohelix Metamaterials
Leah Pandiscia, PhD
March 24, 2020
A type of cellulose solvent, i.e., aqueous N-methylmorpholine- N-O xide (NMMO) solutions, was used to modify cellulose nanocrystal (CNC) photonic films. CNC… Continue reading Responsive and patterned cellulose nanocrystal films modified by N-methylmorpholine-N-oxide
Leah Pandiscia, PhD
March 24, 2020
Cellular delivery of biomacromolecules is vital to medical research and therapeutic development. Cationic polymers are promising and affordable candidate vehicles… Continue reading Polycation Architecture and Assembly Direct Successful Gene Delivery: Micelleplexes Outperform Polyplexes via Optimal DNA Packaging
Leah Pandiscia, PhD
March 24, 2020
A poly(ethylene glycol)-based thermogel can capture an iron ion (Fe3+) through a crown ether-like coordination bond between the oxygen atom… Continue reading Iron Ion-Releasing Polypeptide Thermogel for Neuronal Differentiation of Mesenchymal Stem Cells
Leah Pandiscia, PhD
March 24, 2020
Mycobacterium abscessus belongs to a group of rapidly growing mycobacteria (RGM) and accounts for approximately 65–80% of lung disease caused by… Continue reading Characterization of the genomically encoded fosfomycin resistance enzyme from Mycobacterium abscessus
Leah Pandiscia, PhD
March 24, 2020
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved cysteine residues to catalyze thiol-disulfide exchange reactions.… Continue reading An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone
Leah Pandiscia, PhD
March 24, 2020