Circular Dichroism Archives

A comparative and systematic approach to desolvation and self-assembly methods for synthesis of piperine-loaded human serum albumin nanoparticles

2019 / Colloids and Surfaces B: Biointerfaces

The present work aimed to accomplish a comparative and principled study on desolvation and self-assembly methods for synthesis of piperine-loaded… Continue reading A comparative and systematic approach to desolvation and self-assembly methods for synthesis of piperine-loaded human serum albumin nanoparticles

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

2019 / Cell Reports

Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive… Continue reading A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

Controlling Supramolecular Chirality in Peptide−π-Peptide Networks by Variation of the Alkyl Spacer Length

2019 / Langmuir

Self-assembled supramolecular organic materials with π-functionalities are of great interest because of their applications as biocompatible nanoelectronics. A detailed understanding… Continue reading Controlling Supramolecular Chirality in Peptide−π-Peptide Networks by Variation of the Alkyl Spacer Length

Fusion proteins with chromogenic and keratin binding modules

2019 / Scientific Reports

The present research relates to a fusion protein comprising a chromogenic blue ultramarine protein (UM) bound to a keratin-based peptide… Continue reading Fusion proteins with chromogenic and keratin binding modules

Automated High-Throughput Capillary Circular Dichroism and Intrinsic Fluorescence Spectroscopy for Rapid Determination of Protein Structure

2019 / Analytical Chemistry

Assessing the physical stability of proteins is one of the most important challenges in the development, manufacture, and formulation of… Continue reading Automated High-Throughput Capillary Circular Dichroism and Intrinsic Fluorescence Spectroscopy for Rapid Determination of Protein Structure

Optical Detection of Denatured Ferritin Protein via Plasmonic Gold Nanoparticles Exposure through Aminosilane Solution

2019 / Nanomaterials

The presence of denatured proteins within a therapeutic drug product can create a series of serious adverse effects, such as… Continue reading Optical Detection of Denatured Ferritin Protein via Plasmonic Gold Nanoparticles Exposure through Aminosilane Solution

Enhancing the thermal stability of soy proteins by preheat treatment at lower protein concentration

2020 / Food Chemistry

The heat-induced aggregation of edible proteins has been regarded as one of the critical challenges for their application in protein-enriched… Continue reading Enhancing the thermal stability of soy proteins by preheat treatment at lower protein concentration

Biochemical and gelling properties of silver carp surimi as affected by harvesting season and chopping time

2019 / Journal of Food Processing and Preservation

Biochemical and gelling properties of silver carp surimi as affected by harvesting season and chopping process were investigated. Myosin from… Continue reading Biochemical and gelling properties of silver carp surimi as affected by harvesting season and chopping time

Two new 23S,26R-hydroxylated spirostanoid saponins from the fruits of Solanum indicum var. recurvatum

2020 / Steriods

Solanum indicum var. recurvatum, distributed mainly in Hekou, Simao and Menghai areas of Yunnan province, China, is characterized by stellate pubescent leaves… Continue reading Two new 23S,26R-hydroxylated spirostanoid saponins from the fruits of Solanum indicum var. recurvatum

Theranostic Application of a Novel G-Quadruplex-Forming DNA Aptamer Targeting Malate Synthase of Mycobacterium tuberculosis

2019 / Molecular Therapy - Nucleic Acids

The successful management of tuberculosis (TB) requires efficient diagnosis and treatment. Further, the increasing prevalence of drug-resistant TB highlights the… Continue reading Theranostic Application of a Novel G-Quadruplex-Forming DNA Aptamer Targeting Malate Synthase of Mycobacterium tuberculosis

Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049

2019 / Synthetic and Systems Biotechnology

Microbes serve as the most important resource for drug discovery. During our screening for bioactive compounds from our natural products… Continue reading Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049

Baicalein suppresses Repeat Tau fibrillization by sequestering oligomers

2019 / Archives of Biochemistry and Biophysics

Alzheimer’s disease (AD) is a neurodegenerative disorder caused by protein misfolding, aggregation and accumulation in the brain. A large number… Continue reading Baicalein suppresses Repeat Tau fibrillization by sequestering oligomers

Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches

2019 / Biochimie

Rad51 is a key protein in DNA repair by homologous recombination and an important target for development of drugs in… Continue reading Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches

Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk

2019 / Nature Communications

Web spiders connect silk proteins, so-called spidroins, into fibers of extraordinary toughness. The spidroin N-terminal domain (NTD) plays a pivotal… Continue reading Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk

Shape-Dependent, Chiro-optical Response of UV-Active, Nanohelix Metamaterials

2019 / Nano Letters

We harness a synergy between morphology and the electromagnetic response of semiconducting material to engineer the chiro-optical properties of metamaterials… Continue reading Shape-Dependent, Chiro-optical Response of UV-Active, Nanohelix Metamaterials

Responsive and patterned cellulose nanocrystal films modified by N-methylmorpholine-N-oxide

2020 / Carbohydrate Polymers

A type of cellulose solvent, i.e., aqueous N-methylmorpholine- N-O xide (NMMO) solutions, was used to modify cellulose nanocrystal (CNC) photonic films. CNC… Continue reading Responsive and patterned cellulose nanocrystal films modified by N-methylmorpholine-N-oxide

Polycation Architecture and Assembly Direct Successful Gene Delivery: Micelleplexes Outperform Polyplexes via Optimal DNA Packaging

2019 / JACS

Cellular delivery of biomacromolecules is vital to medical research and therapeutic development. Cationic polymers are promising and affordable candidate vehicles… Continue reading Polycation Architecture and Assembly Direct Successful Gene Delivery: Micelleplexes Outperform Polyplexes via Optimal DNA Packaging

Iron Ion-Releasing Polypeptide Thermogel for Neuronal Differentiation of Mesenchymal Stem Cells

2019 / Biomacromolecules

A poly(ethylene glycol)-based thermogel can capture an iron ion (Fe3+) through a crown ether-like coordination bond between the oxygen atom… Continue reading Iron Ion-Releasing Polypeptide Thermogel for Neuronal Differentiation of Mesenchymal Stem Cells

Characterization of the genomically encoded fosfomycin resistance enzyme from Mycobacterium abscessus

2019 / MedChemComm

Mycobacterium abscessus belongs to a group of rapidly growing mycobacteria (RGM) and accounts for approximately 65–80% of lung disease caused by… Continue reading Characterization of the genomically encoded fosfomycin resistance enzyme from Mycobacterium abscessus

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

2019 / plos pathogens

Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved cysteine residues to catalyze thiol-disulfide exchange reactions.… Continue reading An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

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