2019 / Analytical and Bioanalytical Chemistry
The i-motif is a biologically relevant non-canonical DNA structure formed by cytosine-rich sequences. Despite the importance of the factors affecting… Continue reading Assessing the influence of pH and cationic strength on i-motif DNA structure
2019 / International Journal of Pharmaceutics
Only few adjuvants are licensed for use in humans and there is a need to develop safe and improved vaccine… Continue reading One-pot synthesis and characterization of ovalbumin-conjugated gold nanoparticles: A comparative study of adjuvanticity against the physical mixture of ovalbumin and gold nanoparticles
2019 / Journal of the Science of Food and Agriculture
Peanut is among the most common of food allergies, and one of its allergens is Ara h 2. A previous… Continue reading Polyphenol‐oxidase‐catalyzed cross‐linking of Ara h 2: reaction sites and effect on structure and allergenicity
2019 / Inorganic Chemistry Frontiers
Chiral separation is of critical importance in many areas spanning from pharmaceutics and agriculture to catalysis. Coordination polymers and metal–organic… Continue reading Enantioselective separation under humid conditions by chiral Hofmann clathrates: new opportunities for vintage materials
2019 / Carbohydrate Research
As part of our ongoing investigation of the bioactive constituents from the roots of Glycyrrhiza uralensis Fisch., seven new flavonoid glycosides (1–7)… Continue reading Seven new flavonoid glycosides from the roots of Glycyrrhiza uralensis and their biological activities
2019 / Scientific Reports
Two new harziane diterpene lactones, possessing a 6/5/7/5-fused carbocyclic core containing a lactone ring system, harzianelactones A and B (1 and 2),… Continue reading Potent Phytotoxic Harziane Diterpenes from a Soft Coral-Derived Strain of the Fungus Trichoderma harzianum XS-20090075
2019 / Scientific Reports
Hearing and balance rely on the transduction of mechanical stimuli arising from sound waves or head movements into electrochemical signals.… Continue reading Nanomechanics of tip-link cadherins
2019 / Biochemistry
The G98R mutation in αA-crystallin is associated with the onset of presenile cataract and is characterized biochemically by an increased… Continue reading Functional Rescue of Cataract-Causing αA-G98R-Crystallin by Targeted Compensatory Suppressor Mutations in Human αA-Crystallin
2019 / Journal of Bacteriology
The prokaryotic βγ-crystallins are a large group of uncharacterized domains with Ca2+-binding motifs. We have observed that a vast number… Continue reading βγ-Crystallination Endows a Novel Bacterial Glycoside Hydrolase 64 with Ca2+-Dependent Activity Modulation
2019 / biomolecules
Studying drug–protein interactions has gained significant attention lately, and this is because the majority of drugs interact with proteins, thereby… Continue reading Unraveling Binding Mechanism of Alzheimer’s Drug Rivastigmine Tartrate with Human Transferrin: Molecular Docking and Multi-Spectroscopic Approach towards Neurodegenerative Diseases
2019 / Molecular Biotechnology
Angiogenesis is a biological process finely tuned by a plethora of pro- and anti-angiogenic molecules, among which vascular endothelial growth… Continue reading Biochemical and Conformational Characterization of Recombinant VEGFR2 Domain 7
2020
Many pathogens take advantage of the dependence of the host on the interaction of hundreds of extracellular proteins with the… Continue reading The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
2003 / Journal of Virology
Coronavirus entry is mediated by the viral spike (S) glycoprotein. The 180-kDa oligomeric S protein of the murine coronavirus mouse… Continue reading The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex
2014 / Nature Communications
A novel human coronavirus, Middle East respiratory syndrome coronavirus (MERS-CoV), has caused outbreaks of a SARS-like illness with high case… Continue reading Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor
2004 / Journal of Biological Chemistry
The spike (S) glycoprotein of coronaviruses mediates viral entry into host cells. It is a type 1 viral fusion protein… Continue reading Structural Characterization of the SARS-Coronavirus Spike S Fusion Protein Core
2019 / Asian Journal of Pharmaceutical Sciences
Squalene-based oil-in-water (O/W) emulsions have been used as effective and safe adjuvants in approved influenza vaccines. However, there are concerns… Continue reading Development of novel cationic microemulsion as parenteral adjuvant for influenza vaccine
2019 / Biophysical Chemistry
The impact of the differently hydrated non-electrolytes (protein structure destabilizers) on the fibrillation of hen egg white lysozyme (HEWL) was… Continue reading Amyloid fibril formation in the presence of water structure-affecting solutes
2019 / Chemistry of Natural Compounds
Eleven compounds (1–11), including two new compounds (1, 2), were isolated from the antioxidant portion of the alcoholic extract of Urtica… Continue reading The Antioxidant Compounds from Urtica fissa Flowers
2019 / Bioorganic Chemistry
Seven previously undescribed metabolites, designated as tricycloalternarenes Q–W (1–7), were isolated and identified from the fermented rice substrate of fungus Alternaria… Continue reading New cytotoxic tricycloalternarenes from fungus Alternaria brassicicola
2019 / Virus Research
The coat protein (CP) is the only structural protein present in the polyprotein of bean common mosaic virus. The well… Continue reading Elucidating the functional aspects of different domains of bean common mosaic virus coat protein
