Evaluation of the stereoselectivity for titanium(IV)-based coordination entities induced by the enantiopure diphenylethene-1,2-diamine ligand

2019 / Inorganica Chimica Acta

This article describes the formation of neutral TiO4N2-based coordination entities where the titanium centers are coordinated by oxygenated ligands incorporating… Continue reading Evaluation of the stereoselectivity for titanium(IV)-based coordination entities induced by the enantiopure diphenylethene-1,2-diamine ligand

Heather Haffner

Platelet-driven formation of interface peptide nano-network biosensor enabling a non-invasive means for early detection of Alzheimer’s disease

2019 / Biosensors and Bioelectronics

Soft material fabricated with DNA origami or peptide cross-linking technique may be promising theranostic platforms in the future; however, their… Continue reading Platelet-driven formation of interface peptide nano-network biosensor enabling a non-invasive means for early detection of Alzheimer’s disease

Heather Haffner

Structural studies of the Hsp70/Hsp90 organizing protein of Plasmodium falciparum and its modulation of Hsp70 and Hsp90 ATPase activities

2019 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

HOP is a cochaperone belonging to the foldosome, a system formed by the cytoplasmic Hsp70 and Hsp90 chaperones. HOP acts… Continue reading Structural studies of the Hsp70/Hsp90 organizing protein of Plasmodium falciparum and its modulation of Hsp70 and Hsp90 ATPase activities

Heather Haffner

Design and Biological Evaluation of m-Xylene Thioether-Stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled–Coil Fusion Complex

2019 / Journal of Medicinal Chemistry

Short peptide-based inhibition of fusion remains an attractive goal in antihuman immunodeficiency virus (HIV) research based on its potential for… Continue reading Design and Biological Evaluation of m-Xylene Thioether-Stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled–Coil Fusion Complex

Heather Haffner

Novel aminoquinoline-based solvatochromic fluorescence probe: Interaction with albumin, lysozyme and characterization of amyloid fibrils

2020 / Dyes and Pigments

A novel aminoquinoline derivative (AQ) was synthesized and applied as a solvatochromic fluorescent probe to study proteins and their alterations. AQ is… Continue reading Novel aminoquinoline-based solvatochromic fluorescence probe: Interaction with albumin, lysozyme and characterization of amyloid fibrils

Heather Haffner

Protein Flexibility of the α-Ketoglutarate-Dependent Oxygenase Factor-Inhibiting HIF-1: Implications for Substrate Binding, Catalysis, and Regulation

2019 / Biochemistry

Protein dynamics are crucial for the mechanistically ordered enzymes to bind to their substrate in the correct sequence and perform… Continue reading Protein Flexibility of the α-Ketoglutarate-Dependent Oxygenase Factor-Inhibiting HIF-1: Implications for Substrate Binding, Catalysis, and Regulation

Heather Haffner