2019 / Biochemical and Biophysical Research Communications
Hepatitis B virus X protein (HBx) possesses a BH3-like motif that directly interacts with the anti-apoptotic proteins, Bcl-2 and Bcl-xL.… Continue reading NMR characterization of the interaction between Bcl-xL and the BH3-like motif of hepatitis B virus X protein
2019 / ACS Chemical Neuroscience
Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is a salient feature of amyotrophic lateral sclerosis (ALS), a debilitating… Continue reading Characterizing TDP-43307–319 Oligomeric Assembly: Mechanistic and Structural Implications Involved in the Etiology of Amyotrophic Lateral Sclerosis
2019 / Microbial Cell Factories
S-Formylglutathione is hydrolyzed to glutathione and formate by an S-formylglutathione hydrolase (SFGH) (3.1.2.12). This thiol esterase belongs to the esterase… Continue reading Structural and functional characterization of a novel cold-active S-formylglutathione hydrolase (SfSFGH) homolog from Shewanella frigidimarina, a psychrophilic bacterium
2019 / Biomacromolecules
Herein we demonstrated a novel lipase-catalyzed synthesis of isotactic D-/L-poly(aspartate-octanediol) ester containing long chain alcohols backbone and discovered their stereocomplex feature… Continue reading Enzymatic Synthesis and Stereocomplex Formation of Chiral Polyester Containing Long-Chain Aliphatic Alcohol Backbone
2019 / Journal of Food Biochemistry
To further clarify the effect of the oxidation of egg yolk high‐density lipoprotein (EYHDL) on the protein structure and emulsification,… Continue reading Variation in the structure and emulsification of egg yolk high‐density lipoprotein by lipid peroxide
2019 / DNA Repair
In order to understand in which biological processes the four-stranded G-quadruplex (G4) DNA structures play a role, it is important… Continue reading Identification of putative G-quadruplex DNA structures in S. pombe genome by quantitative PCR stop assay
2019 / ACS Omega
Phosphorylation at the intracellular C-terminal domain (CTD) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors induces conformational rigidity. Such intracellular alterations to the… Continue reading Mechanistic Understanding of the Phosphorylation-Induced Conformational Rigidity at the AMPA Receptor C-terminal Domain
2019 / Chemistry A European Journal
1‐Aminocyclopropane‐1‐carboxylic oxidase (ACCO) is a non‐heme iron(II)‐containing enzyme involved in the biosynthesis of the phytohormone ethylene, which regulates fruit ripening… Continue reading The Hunt for the Closed Conformation of the Fruit‐Ripening Enzyme 1‐Aminocyclopropane‐1‐carboxylic Oxidase: A Combined Electron Paramagnetic Resonance and Molecular Dynamics Study
2019 / International Journal of Biological Macromolecules
Recent reports suggest influence of anti-cancer anthracyclines on telomere dysfunction and their possible interaction with G-quadruplex (G4) DNA as an… Continue reading Molecular recognition of 3 + 1 hybrid human telomeric G-quadruplex DNA d-[AGGG(TTAGGG)3] by anticancer drugs epirubicin and adriamycin leads to thermal stabilization
2019 / Polyhedron
Alizarin (DHA), a simple analogue of the anthracycline core was used to form a complex with MnII to see if the… Continue reading Characterization of a MnII complex of Alizarin suggests attributes explaining a superior anticancer activity: A comparison with anthracycline drugs
2019 / Journal of Medicinal Chemistry
In order to optimize the potency of the first serum-stable peptide agonist of CD47 (PKHB1) in triggering regulated cell death… Continue reading Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells
2019 / Langmuir
In recent times, collagen, which is one of the most abundant proteins in animals, has appeared to be an attractive… Continue reading Electron Transport in Muscle Protein Collagen
2019 / Biophysical Journal
Understanding local conformations of DNA at the level of individual nucleic acid bases and base pairs is important for elucidating… Continue reading Local DNA Base Conformations and Ligand Intercalation in DNA Constructs Containing Optical Probes
2019 / Biochemical and Biophysical Research Communications
Association between two motor subunits through the rod/stalk domain enables molecular motors to walk processively on protein filaments. Previous studies… Continue reading The structural dynamics of the kinesin-2 stalk heterodimer and its biological relevance
2019 / Sustainable Chemistry and Pharmacy
Collagen is the major fibrillar component and protein in both human and animal connective tissue. It is applied in medical… Continue reading Collagen from Turkey (Meleagris gallopavo) tendon: A promising sustainable biomaterial for pharmaceutical use
2020 / Chemical Physics
The effect of trehalose on the activity and structural change of lysozyme induced by the chemical denaturant guanidinium chloride (GdmCl)… Continue reading Molecular level insight into the counteraction of trehalose on the activity as well as denaturation of lysozyme induced by guanidinium chloride
2019 / Bioorganic Chemistry
Vernonia extensa, known as “Phim Phai Lin” in Thai, is distributed in most regions of Thailand. The plant has been… Continue reading Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells
2019 / Science of The Total Environment
Due to excessive consumption of antibiotics, antibiotic resistance genes (ARGs) become a ubiquitous pollutant in aquatic environments. Graphene oxide (GO),… Continue reading Cleavage and transformation inhibition of extracellular antibiotic resistance genes by graphene oxides with different lateral sizes
2019 / International Journal of Pharmaceutics
Bioactive peptides are attractive candidates for drug development. QAW is a tripeptide that is obtained from an anti-inflammatory protein-Annexin A1… Continue reading Targeted and MMP-2/9 responsive peptides for the treatment of rheumatoid arthritis
2019 / Tetrahedron
Three new caryophyllene sesquiterpenes, pestalotiopsins I–K, one new chromone, pseudopestalone, and one new 10-membered macrolide, decarestrictine Q, were isolated from… Continue reading Caryophyllene sesquiterpenes, chromones and 10-membered macrolides from the marine-derived fungus Pseudopestalotiopsis sp. PSU-AMF45
