DEVELOPMENT AND VALIDATION OF A RP – LC METHOD FOR DISSOLUTION TEST OF EFAVIRENZ TABLETS AND ITS APPLICATION TO DRUG QUALITY CONTROL STUDIES

2013 / Asian Journal of Pharmaceutical and Clinical Research

A liquid chromatographic method is developed to evaluate a new dissolution profile of Efavirenz in tablet dosage form. The dissolution …

DJ Tognarelli

Development and Validation of Rapid HPLC Method for Determination of Doxofylline in Bulk Drug and Pharmaceutical Dosage Forms

2009 / Journal of Analytical Chemistry

A simple, selective, rapid, and economical reversed phase high performance liquid chromatogra phy(RPHPLC) method for the determination of doxofylline in …

DJ Tognarelli

Development, Validation and Statistical Correlation of RP–LC Methods for Determination of Atazanavir Sulfate in Capsule Dosage Form

2012 / Journal of Chemistry

To study the effective therapeutic bioavailability of Atazanavir Sulfate (ATV), administered singly or in combination with Ritonavir, a cost effective …

DJ Tognarelli

A validated stability indicating RP-HPLC method for valganciclovir, identification and characterization of forced degradation products of valganciclovir using LC-MS/MS

2014 / Acta Chromatographica

The objective of the present study was to report the stability of novel antiviral drug, valganciclovir based on the information …

DJ Tognarelli

Peak decay analysis and biointeraction studies of immunoglobulin binding and dissociation on protein G affinity microcolumns

2018 / Methods, Volume 146, 15 August 2018, Pages 39-45

Protein G can be a valuable binding agent for antibodies and immunoglobulins in methods such as immunosensors, chromatographic-based immunoassays, and …

DJ Tognarelli

Enantiomeric impurity analysis using circular dichroism spectroscopy with United States Pharmacopeia liquid chromatographic methods

2018 / Journal of Pharmaceutical and Biomedical Analysis

Over 300 chiral drug substances lack official United States Pharmacopeia (USP) methods for the enantiomeric purity determination. Because enantiomeric analysis …

Leah Pandiscia, PhD