Three new indole alkaloids, named kopsioffines A–C (1–3), possessing relatively novel ten-membered lactam ring, and one known compound (11,12-demethoxy-16-deoxypauciflorine, 4) were… Continue reading Three novel indole alkaloids from Kopsia officinalis
Leah Pandiscia, PhD
July 28, 2017
A simple method for interlocking glucose oxidase (GOx) and horseradish peroxidase (HRP) in cellulose fibers using poly(acrylic acid) (PAA) as… Continue reading Nanoarmoring of Enzymes by Interlocking in Cellulose Fibers With Poly(Acrylic Acid)
Leah Pandiscia, PhD
July 28, 2017
Metals such as Cu2+, Fe3+, and Zn2+ are major contributors to the biology of a brain in stages of health, aging,… Continue reading Anti-fibrillogenic and fibril destabilizing effects of metal ions on cystatin fibrils
Leah Pandiscia, PhD
July 28, 2017
The transcription factor NF-κB is known to induce tumor promotion and progression and is considered a major player in inflammation-driven… Continue reading Cancer chemopreventive activity of compounds isolated from Waltheria indica
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
A comprehensive investigation of the chemical constituents of the leaves of Upuna borneensis (Dipterocarpaceae) was performed. Three new glucosides of resveratrol oligomers… Continue reading Absolute configuration of resveratrol oligomer glucosides isolated from the leaves of Upuna borneensis
Leah Pandiscia, PhD
July 28, 2017
Tau, a family of microtubule-associated protein (MAP) that exists in six isoforms, is involved in the etiology of Alzheimer’s and… Continue reading Electrochemical studies of tau protein-iron interactions − potential implications for Alzheimer’s Disease
Leah Pandiscia, PhD
July 28, 2017
DNA transposons can be employed for stable gene transfer in vertebrates. The Sleeping Beauty (SB) DNA transposon has been recently… Continue reading NMR solution structure of the RED subdomain of the Sleeping Beauty transposase
Leah Pandiscia, PhD
July 28, 2017
Binding studies between a multi-targeted anticancer drug, sunitinib (SU) and human serum albumin (HSA) were made using fluorescence, UV-vis absorption,… Continue reading Comprehensive insight into the binding of sunitinib, a multi-targeted anticancer drug to human serum albumin
Leah Pandiscia, PhD
July 28, 2017
A trypsin inhibitor from C. leiandra seeds, named ClTI, was purified, characterized, and its insecticidal activity against Ae. aegypti evaluated. ClTI was purified by DEAE-Cellulose and… Continue reading A trypsin inhibitor purified from Cassia leiandra seeds has insecticidal activity against Aedes aegypti
Leah Pandiscia, PhD
July 28, 2017
Phosvitin is a unique highly phosphorylated protein that plays a role in the regulation of mineralization. This study investigated the… Continue reading Role of phosphorylation of phosvitin in the phase transformation of mineralization
Leah Pandiscia, PhD
July 28, 2017
RNA is known to interact with Mg2 + when assuming higher-ordered tertiary configurations. Structurally, when tRNA molecules interact with Mg2 +, they consistently… Continue reading Characterization of tRNALeu binding interactions with Cu2 + and Pb2 + and their biological implications
Leah Pandiscia, PhD
July 28, 2017
Ring-opening polymerization of S-propargyl-cysteine-N-carboxyanhydride has been used to synthesize conformation switchable poly(S-propargyl-cysteine) starting with l-cysteine, dl- and d-cysteine. Then cationic polypeptides with different backbone… Continue reading Synthesis of conformation switchable cationic polypeptides based on poly(S-propargyl-cysteine) for use as siRNA delivery
Leah Pandiscia, PhD
July 28, 2017
Chloro- and aryl-substituted acetylene monomers having an optically active group were polymerized by a Pd catalyst [(tBu3P)PdMeCl] bearing a bulky… Continue reading Polymerization of optically active disubstituted acetylene monomers by Pd catalyst bearing bulky phosphine ligand
Leah Pandiscia, PhD
July 28, 2017
Photo-responsive materials, particularly those based on peptides, hold much promise for numerous potential applications in biomedicine and bionanotechnology. For these… Continue reading Exploring the Role of Molecular Chirality in Photo-Responsiveness of Dipeptide-Based Gels
Leah Pandiscia, PhD
July 28, 2017
A pair of lanthanide metal chiral coordination polymers (CCPs) based on (R)- and (S)-5-(1-carboxyethoxy) isophthalic acid (H3CIA), namely, [Ce2((R)-CIA)2(H2O)5]·2H2O (1-D)… Continue reading A pair of Ce(III) coordination polymers based on chiral semi-rigid T-shaped tricarboxylate enantiomeric ligands: Synthesis, Crystal Structure and Properties
Leah Pandiscia, PhD
July 28, 2017
The binding ability of viologen herbicide with bovine serum albumin (BSA) has been investigated to understand viologen associated hazards by… Continue reading Evidence of bovine serum albumin-viologen herbicide binding interaction and associated structural modifications
Leah Pandiscia, PhD
July 28, 2017
Antimicrobial peptides (AMPs) have shown the ability to inhibit planktonic bacteria and biofilms. The objectives of this study were to de… Continue reading De novo synthetic short antimicrobial peptides against cariogenic bacteria
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The interior of the cell is tightly packed with various biological macromolecules, which affects physiological processes, especially protein folding process.… Continue reading Effects of macromolecular crowding on alkaline phosphatase unfolding, conformation and stability
Leah Pandiscia, PhD
July 28, 2017